Actually, this thread has prompted me to ask a question that I've been wondering about for a while.
Does anyone else here experience massively idiosyncratic reactions to ACEi's like Diphenhydramine and Promethazine?
I personally cannot use them as they induce full blown delirium at therapeutic levels
40mg of Promethazine has me trying to kill the hordes of spiders (another question: why is it always spiders?! Why not butterflies? To misquote HP) that erupt from every surface whilst a bear/dog hybrid sits in my back garden for 2 hours.
50-100mg DPH has me hiding under the covers from the gang of demonic shadow creatures that have climbed through my bedroom window to kill me as horrendous wounds appear on my hands, becoming more gruesome with every second spent looking at them.
I deal with intermittent psychosis but this feels entirely different and only lasts as long as the drug is in my system so I don't believe it is simply an induction of latent psychoses.
DPH is essentially useless to me now as a sleep aid due to similar problems. I don't have full blown hallucinations at 50-100mg but I do end up re-living pretty much the same set of circumstances which led me to stop taking it.
- I will get drowsy and lay down. When I start to doze off I'll have brain zaps. I'll see flashes of light behind my eye lids and startle awake.
- Once that starts going on I'll find myself begin somewhat stimulated by the DPH, though I'll continue to doze and startle awake for some time.
- If I don't sleep and get out of bed everything takes on the feeling of begin evil. It's hard to describe but it feels like you're in a horror movie I guess. I'm constantly on alert and find it impossible to relax.
Now if I do go to sleep I end up in a bad way;
I'll have an episode that pretty much always plays out the same way. I will become afraid for my life, for what reason I don't know. I just think there is something in the room with me. I'll try to flee from it but I am totally blind and find it hard to move. Gravity feels like it's turned up and I feel like I'm under water. I also feel like I'm really dissociated and that at any moment I could just slip away forever.
So in that state I end up attempting to seek out help. I'll call out for help but my yell is reduced to a whisper and I can barely make the words come out. If I'm at home I'll be crawling up the stairs on all fours towards the bedroom of my roommate. When I do eventually crawl all the way up there I'm instantly transported back to my bed. This series of events repeats over and over again until I wake up many hours later in a cold sweat.
I've had this same type of episode in two different locations. At home and two times while visiting family. I am unsure if I'm just dreaming the events or if I'm sleep walking. At any rate no one has even mentioned my waking them in the middle of the night so I'm assuming I'm just dreaming all this and it brings on some form of sleep paralysis in me.
Eventually I stopped taking it all together and advise others not to.