Sure. If you take a lot of shrooms, like in the +5 gram range, you can get your ass handed to you. I have cried many tears, mid to late trip from some of those heavy experiences. One thing about mushrooms is that if you take enough, you can have a really, really insightful, emotional trip, and it isn't always easy. It is cathartic, though, and I am always glad I did it. I used to use a blender to blend LOTS of fresh, wet shrooms with OJ, and drink it down. It took everything I had to NOT puke, but when that shit kicked in, I was shot into the ether. Some of the greatest trips ever on them, but they beat you up a little, again, especially at high doses. I don't care for low dose trips, so for me, it's 5 and up and do the do. Some of the most haunting experiences I've had as a human being were on mushroom trips. When you want to have them kick in within minutes, powderize and capsulize them. They start kicking in with 15 minutes, and before you know it, you close your eyes and see the walled room of weird cartoonish figures looking at you. It's intimidating at times, but rocks your world.