^^ Haha nice way to make that point..
Here's Dennis McKenna. Watch and weep all those who doubted the insights and honesty of the MetanoiaMan. At the 5:10 mark he states, "The only difference between Psilocin and DMT is one molecule that allows Psilocin to be orally active WITHOUT a MAO inhibitor, and at higher dosages, you are in tryptamine land." Mushrooms, Ayahuasca, DMT, all get you into that place. Now stop your ignorant yapping and realized Ayahuasca and high dose mushrooms is the same experience. Stop fetishizing Ayahuasca as something new and different worth a ten hour plane ride. Pleased to educate all my Psychedelic Brothers and sisters...
https://www.youtube.com/watch?v=-yF2eJP_C4U
Just so that nobody actually is convinced by your 'argument'...
He does not state that, he states that DMT and psilocin are just one 'molecule away', by which he must mean moiety (group, the 4-hydroxy), and then goes on to say that this tryptamine land is very much alike, I'd say that is his point. In terms of purpose, it both 'gets the job done' i.e. tryptamine land. But alike even very much alike is not exactly the same.
I too find that especially 4-AcO-DMT feels a lot like DMT qualitatively, however the whole kinetics / timeline of the experience is just different enough to make the trips significantly different. Just like route of administration for one and the same drug can mean quite a bit of difference. There are some psychedelics that are orally taken quite innocuous even up to pretty high doses, but snorted or via another parenteral route turn pretty drastic. That demonstrates the importance of kinetics for which absorption plays a role but also the extent to which the body is able to 'anticipate' the peak that is to come and to counter it.
MAOI do a pretty good job at undermining those bodily countermeasures, and I could clearly feel that qualitatively when I tried mushrooms with a MAOI.
So: DMT and psilocin, and also 4-AcO-DMT or other esters like psilocybin are all 'quite similar', but ROA and addition of MAOI can play a huge role - so please stop making incorrect deductions or rather... unhelpful oversimplifications.
What Dennis mcKenna says in an interview, wow, such scientific evidence..
Also: I think that schizophrenics should avoid psychedelics and other 'mind expanding' drugs like the plague. Having the boundaries between fantasy and reality inhibited is not conductive / healthy for that syndrome. Seems obvious.
(This post was moved from the other thread)