Been using since 2005. At first only every 3 months. For the past two years been less prudent and taking it monthly or so. Usually dosage is 130mg + 100mg few hours later.
Rolls are noticeably shorter now, sometimes barely lasting over an hour.
Back in the day I never felt depressed on comedown, just slightly emo for a day or two. These days the comedown is much more real and lasts a day or two.
Time for a longish break: an hour roll for 2 days of sadness is not worth it. Overall no regrets, I am glad I had the experiences that I did.
Everything in moderation as they say.
Quick edit, know a few people who have only been rolling for about 6 months or so, but weekly, sometimes twice a week. I dont even know why they take it anymore, as they do not roll at all, maybe for like 10 minutes lol.