Diazepam + Clonidine + Hydroxyzine, washed down with a beer.
The diazepam relaxes your muscles and reduces anxiety/depression, clonidine slows down the heart rate, and the hydroxyzine introduces some sedation. Clonazepam + Tizanidine+ Doxylamine works nicely as an alternative.
Wait 30 minutes, see how you feel, and repeat it once if the effect wasn't sufficient. But you're looking to ease the symptoms not get stupefied unconscious.
If you use opiates habitually, then they are obviously a must, and will take the place of alcohol and possibly even a benzo. But it's probably better not to start using them for comedown relief.