Well they certainly have worn off by a week, and I still feel the great mental reset for 2-3 weeks.The effects do not wear off at 24 hours active amounts are still lighting up your opioid receptors even if you don’t feel a strong high anymore
Also, when I don’t get a good high, I am looking for another high within 8 hours of the last dose. Which corresponds to when many addicts feel withdrawals. I think if they are “lighting up” your receptors at the 24 hour mark then we wouldn’t see much of an addiction issue with them, as it would be very easy to go a couple days without. So you’re off base here I think.