Hi all. A friend of mine is thinking of taking E for the first time. Knows a lot of friends that do it. Drinks every weekend and wants to know a few things. He takes an antihistamine, Zyrtec, daily for a hives condition called Cholinergic Urticaria. Heat hives bascially. 10mg of zyrtec cures it for the day and he can live normally. He can drink alcohol fine on this with no side effects. Would it be safe to have with E/MDMA? He would not take alcohol that night either just the E. He doesn't have any heart issues to his knowledge, is a bit unfit from being lazy over the years but other than that is fine. If he had an underlying heart problem it would have risen with heavy drinking/weed/smoking/other strenous stuff right? The E he is getting is from friends who buy it all the time and have a great time on it.