Abusernamer
Greenlighter
- Joined
- Feb 20, 2022
- Messages
- 9
I've a lot to say, but i'll try to remember to mention all important points. This will be a hastily written thread, but an important one.
I feel no euphoria from IV morphine. Or any other opiate. I feel a pressure at the back of my head, but i don't nod, i don't get flushed. I get a rush from some opiates, but not euphoria. I may have found the biological reason for this, as well as a way to temporarily make your body enjoy opiates as much as an addict does.
This is for those who don't like opiates, who feel heavy but not happy and warm and fuzzy on opiates, but are willing to IV them with certain potentiators to study how they work.
The reason they have to be IV'd for this experiment, is that, in my theory, traditional potentiation methods only lengthen or shorten the time the opiate stays in your body, they affect the metabolic rate by affectimg metabolic enzymes to achieve this, usually either inhibiting or inducing CYP3A4 and CYP2D6.
Some of the techniques used by my "new potentiators" on the one hand reduce the effectiveness of opiates taken enterally (orally), while on the other, they boost the euphoria astronomically when the drugs are taken parentenally (IV'd), because they induce certain metabolic enzymes, which has a heavy de-potentiating effect on enteral ROAs and a slighter de-potentiating effect on parentenal ROAs. Research needs to be done to isolate a substance which has the "new potentiator" effect, but without the side effects of inducing those metabolic enzymes.
Yet, and this is my as of yet unproven thesis, there is another "kind" of potentiation, which specifically changes how intensely your body reacts to opiates. I suspect people who feel no euphoria, simply have biological differences in the intensity of their body's response to opiates. Let's call this "true potentiation". I'll explain what substances do this at a later point.
If you're interested, read along.
---These are the facts:
I do not like opiates because they feel like pressure, not pleasure. When i use my method of "true potentiation", that pressure turns to physical pleasure and mental bliss (at least when using IV Morphine, other opiates are untested), and i am certain that if i take even more of the "true potentiator", this may elevate my enjoyment of IV morphine even higher.
This method of true potentiation does build tolerance to the potentiating effects fast, but the tolerance to the "true potentiation" effects also returns very fast, and there are no withdrawal symptoms.
This effects of "true potentiation", since it's euphoric effects are not merely caused by the induction of metabolic enzymes, are caused by one of the active agents in St John's Wort.
The euphoric "true potentiation" effects of St John's Wort on IV morphine euphoria are NOT due to it's effects on the CYP2D6 and CYP3A4 enzymes, as morphine is not metabolized by either.
So far, i have confirmed only IV morphine to be affected by this "true potentiation" using st john's wort, haven't tested other opiates yet but IV oxy is up next for personal testing
Fentanyl is almost certainly unaffected by St John's Wort, disproving my retarded theory that the "true potentiation" could temporarily set the brain to enjoy all opiates like an addict does
---These are the theories which need to be researched:
I theorize that this method of "true potentiation" can be used to enable people to enjoy other opiates as well, but that St John's Wort is a relatively bad substance for this, as it induces the metabolism of most if not all opiates, thereby potentially eliminating all of the opiate from the body before the opiate and St John's Worth "true potentiation" even have time to take effect.
There is a study which found that St John's Wort greatly de-potentiates oral oxycodone - but nothing was said of IV oxycodone.
It needs to be reasearched if the de-potentiating effects of St John's Wort on oral oxycodone are because of it's induction of the CYP3A4 and CYP2D6 enzymes by taking substamces which induce these enzymes (thereby proving there indeed is a "special" way St John's Wort potentiates IV morphine that is qualitatively different from standard methods of potentiation), and how this applies to and differs between oral and IV oxycodone.
In addition, it should be studied if traditional methods of oxycodone potentiation (White Grapefruit Juice, Syrian Rue Seeds, CYP2D6 and CYP3A4 inhibitors) make a person who feels no physical euphoria from oxycodone, feel significantly more euphoria from oxycodone. This is again, to prove, that these traditional methods of potentiation cannot make a person who feels no euphoria from opiates, feel euphoria from opiates, and that St John's Wort may have a unique way in which it potentiates opiates, by enabling people to feel euphoria from them.
Research needs to be done to isolate a substance which has the "new potentiator" effect which i theorize are present in St Jon's Wort and separate from CYP3A4 and CYP2D6 enzyme induction, but without the side effects of inducing those metabolic enzymes.
I feel no euphoria from IV morphine. Or any other opiate. I feel a pressure at the back of my head, but i don't nod, i don't get flushed. I get a rush from some opiates, but not euphoria. I may have found the biological reason for this, as well as a way to temporarily make your body enjoy opiates as much as an addict does.
This is for those who don't like opiates, who feel heavy but not happy and warm and fuzzy on opiates, but are willing to IV them with certain potentiators to study how they work.
The reason they have to be IV'd for this experiment, is that, in my theory, traditional potentiation methods only lengthen or shorten the time the opiate stays in your body, they affect the metabolic rate by affectimg metabolic enzymes to achieve this, usually either inhibiting or inducing CYP3A4 and CYP2D6.
Some of the techniques used by my "new potentiators" on the one hand reduce the effectiveness of opiates taken enterally (orally), while on the other, they boost the euphoria astronomically when the drugs are taken parentenally (IV'd), because they induce certain metabolic enzymes, which has a heavy de-potentiating effect on enteral ROAs and a slighter de-potentiating effect on parentenal ROAs. Research needs to be done to isolate a substance which has the "new potentiator" effect, but without the side effects of inducing those metabolic enzymes.
Yet, and this is my as of yet unproven thesis, there is another "kind" of potentiation, which specifically changes how intensely your body reacts to opiates. I suspect people who feel no euphoria, simply have biological differences in the intensity of their body's response to opiates. Let's call this "true potentiation". I'll explain what substances do this at a later point.
If you're interested, read along.
---These are the facts:
I do not like opiates because they feel like pressure, not pleasure. When i use my method of "true potentiation", that pressure turns to physical pleasure and mental bliss (at least when using IV Morphine, other opiates are untested), and i am certain that if i take even more of the "true potentiator", this may elevate my enjoyment of IV morphine even higher.
This method of true potentiation does build tolerance to the potentiating effects fast, but the tolerance to the "true potentiation" effects also returns very fast, and there are no withdrawal symptoms.
This effects of "true potentiation", since it's euphoric effects are not merely caused by the induction of metabolic enzymes, are caused by one of the active agents in St John's Wort.
The euphoric "true potentiation" effects of St John's Wort on IV morphine euphoria are NOT due to it's effects on the CYP2D6 and CYP3A4 enzymes, as morphine is not metabolized by either.
So far, i have confirmed only IV morphine to be affected by this "true potentiation" using st john's wort, haven't tested other opiates yet but IV oxy is up next for personal testing
Fentanyl is almost certainly unaffected by St John's Wort, disproving my retarded theory that the "true potentiation" could temporarily set the brain to enjoy all opiates like an addict does
---These are the theories which need to be researched:
I theorize that this method of "true potentiation" can be used to enable people to enjoy other opiates as well, but that St John's Wort is a relatively bad substance for this, as it induces the metabolism of most if not all opiates, thereby potentially eliminating all of the opiate from the body before the opiate and St John's Worth "true potentiation" even have time to take effect.
There is a study which found that St John's Wort greatly de-potentiates oral oxycodone - but nothing was said of IV oxycodone.
It needs to be reasearched if the de-potentiating effects of St John's Wort on oral oxycodone are because of it's induction of the CYP3A4 and CYP2D6 enzymes by taking substamces which induce these enzymes (thereby proving there indeed is a "special" way St John's Wort potentiates IV morphine that is qualitatively different from standard methods of potentiation), and how this applies to and differs between oral and IV oxycodone.
In addition, it should be studied if traditional methods of oxycodone potentiation (White Grapefruit Juice, Syrian Rue Seeds, CYP2D6 and CYP3A4 inhibitors) make a person who feels no physical euphoria from oxycodone, feel significantly more euphoria from oxycodone. This is again, to prove, that these traditional methods of potentiation cannot make a person who feels no euphoria from opiates, feel euphoria from opiates, and that St John's Wort may have a unique way in which it potentiates opiates, by enabling people to feel euphoria from them.
Research needs to be done to isolate a substance which has the "new potentiator" effect which i theorize are present in St Jon's Wort and separate from CYP3A4 and CYP2D6 enzyme induction, but without the side effects of inducing those metabolic enzymes.
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