Actually, pantherina are also psychoactive and not poisonous (though I have heard you need to be more careful with the dose). In fact,
@Kaleida wrote a trip report about them. She said, I believe, that they feel closer to serotonergic psychedelics than muscaria. But you'll have to do your research on dosage and such because I don't know.
My girlfriend's ex-boyfriend told me about the time he ate them... he and his friends picked a bunch, and he ate a bunch fresh (don't do this). He said he felt like he was dying at first and then everything in his real life disappeared and he lived a thousand lives, and they kept repeating over and over and over again. He said he also met and spoke with god. Eventually he came back all bruised and cut up and his friends were freaking out. Apparently he went super rigid and broke some shit from flailing around and wouldn't respond to anyone the whole time, though his eyes were open and he was moving around.
Amanita muscaria contain ibotenic acid and muscimol, which is toxic, a neurotoxin in fact (though apparently quite psychoactive), which decarboxylates into muscimol (which is what you want). By making the mushroom hot (maybe 135 degrees F, not sure, actually probably more), you convert it to muscimol. The best way is to make tea, but you can also heat them in the oven. Also I have heard that just completely drying them will work. Interestingly, muscimol is a direct GABA-A agonist. Nearly every gabaergic drug is a positive allosteric modulator or an agonist of GABA-B or some other sites. That means it mimics GABA and replaces it in the receptors all throughout your body and brain. Somehow, this produces powerful psychoactive effects. It's absolutely nothing like psilocybin, though.
I bought some dried muscaria last year. I ate 7-8 grams 3 times. The first 2, I just got slightly drowsy and sloppy feeling (I did not make tea, I just ate them. They're rather tasty). The third time, I started feeling poisoned. My body was covered in a cold sweat that wouldn't wipe off. I felt really cold at the same time. My clothes were sticking to me from the sweat and it felt really uncomfortable, but I was freezing so I put even more clothes on. I was shivering quite violently, and occasionally my arms or legs would jerk uncontrollably. I started to get really scared that whoever the person was that picked them fucked up and picked a destroying angel or other poisonous kind, and that I w as in for a slow, painful death over the next 2 days.
Eventually I took a hot shower and felt so much better... I sat down in it and closed my eyes. I felt like I was moving down corridors, sort of like the sliding you get from ketamine. After the showwe I felt better, but not very good. I never got anything more psychoactive than the sliding feeling.
I did it wrote by not making tea, not sure what I was thinking that day because I already knew this stuff.
How do you go about making a tincture?