This question has been bothering me for sometime. Beside the obvious difference in bioavailibilty and the psychological factor of the rush, at equidosage of blood concentration compared to other ROA, do you think there are other known or unkown factors that would increase the addiction and the difficulty to kick the habit ?
To clarify, it is my understanding that the bioavailibilty of Heroin is about 50% when snorted and I would assume around 100% when IV'ed. Let's say Joe have been doing X Heroin daily for a year IV'ed and Jack did the same batch intranasal for the same lenght but he did twice the amount of Joe. Assuming they are genetically identical twins would they have the same difficulty and level of acute withdrawal and PAWS or would Joe, being the IV guy, would have it harder ? And if you think so, why would that be ?
To clarify, it is my understanding that the bioavailibilty of Heroin is about 50% when snorted and I would assume around 100% when IV'ed. Let's say Joe have been doing X Heroin daily for a year IV'ed and Jack did the same batch intranasal for the same lenght but he did twice the amount of Joe. Assuming they are genetically identical twins would they have the same difficulty and level of acute withdrawal and PAWS or would Joe, being the IV guy, would have it harder ? And if you think so, why would that be ?