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Dop3l3ssHopefiend, I really doubt you were vaping that much Acrylfentanyl per session. Maybe Acetylfentanyl (still a ton), but with Acrylfentanyl that'd be some next level tolerance.
So I've been really curious about Acrylfentanyl because it seems incredibly strong. If you're already on fent analogs, it definitely is intriguing for its value, and I won't encourage anyone, including people who are already using analogs, to try it, but here has been my thoughts on what information I have been able to extrapolate about it and the acryloyl group in general (the group that was added/substituted to make this analog).
So first of all, it's an Acryloyl group. It's not an Acryl ester, which you get by combining an Acrylol group with alcohol (no alcohol in this molecule). Acryl esters are typically what become glues and such. So would this compound make a good adhesive? I doubt it. An adhesive at all? I'm not sure, I doubt it, but that doesn't make the acryloyl group any less disconcerting.
Acrylamide is a carcinogen. Now Acrylamide is a chemical all of its own, not a TYPE of chemical. This means Acrylfentanyl isn't necessarily automatically carcinogenic, HOWEVER the IUPAC name for Acrylfentanyl is N-(1-phenethylpiperidin-4-yl)-N-phenylacrylamide. This means "Acrylamide" is in the name. Now how dangerous that is, I can't say for sure, but here's what I CAN say for sure.
Warning: Math ahead!!!
If we assume that Acrylfentanyl contains Acrylamide and all of its carcinogenic qualities, we know based on their molecular weights (Acrylfentanyl: 280.41 g/mol - Acrylamide: 71.08 g/mol), we know that 1 gram of Acrylfentanyl contains 253.5 mg of Acrylamide (71.08 / 280.41 = 0.25348596697692664312970293498805).
According to the EPA you can consume 0.002mg of Acrylamide per day per kg of bodyweight and experience no adverse effects. So a 100kg person can consume 0.2mg of Acrylamide per day with no adverse effects, which converts to 0.789mg (789mcg) of Acrylfentanyl per day based on their molecular mass. According to
drugs.tripsit.me, the Light to Strong dosage range for Acrylfentanyl is 10 to 47.5 mcg (which seems based on the assumption that Acrylfentanyl is twice the strength of fentanyl), which means a 100kg person can take 79 of the smallest doses, or 16 of the largest doses per day without adverse effects. According to these figures, if you stay within these dose ranges, it seems like it's not very carcinogenic. However, like many other fent analog users, I can attest to the fact that your tolerance can easily grow out of control and very easily outgrow these ranges if you're not careful. However, if you careful, you can actually keep your dosage range to a reasonable level, but if you're not careful, and a few specs of powder diluted in 10mL+ of water is enough to get you super high, it's even easier than usual for your tolerance to grow out of control. When creating a volumetrically dosed solution, I recommend making the least concentrated dose possible and
neve increase it under any circumstances.
On the upside, some people consume many times that amount daily based on the foods they eat since lots of foods contain small amounts of Acrylamide. It doesn't mean they will get cancer, but it could increase the chances. On the downside, if you're already getting it from your food, adding more through taking Acrylfentanyl isn't gonna be good for your health.
And then finally, you have to note the fact that it's not like you're consuming something that is part Fentanyl and part Acrylamide. It's a combined chemical, the Acrylamide is bound to the rest of the chemical, and for it to be processed the same way Acrylamide is, the Acrylamide would have to break off the molecule. If this were to happen, and the drug still had its intended effect, don't you think they'd just cook up the version with no Acrylol group? I'm pretty sure that the Acrylamide wont just break off and act like the lone chemical Acrylamide, but I'm no expert. Also, when you look at Acrylfentanyl's structure, you can see what looks like an Acryloyl group attached to it, but if you compare it to an Acrylamide, which has an NH2 bond, it doesn't even look like that exists anywhere. The bond that comes from the Acrylol group has a H2C bond, and no N anywhere as far as I can tell, although it does have 2 Nitrogen atoms, but so does Fentanyl and all of its analogs as far as I can tell. So where the "Acrylamide" in the IUPAC name comes from, I really have no idea except for the fact that it uses an Acryloyl group, as like I've stated and will restate again, I'm not an expert, especially in how these names are determined.
Another example of a dangerous chemical lurking inside an otherwise unassuming chemical/drug/vitamin, is Vitamin B12. 99% of Vitamin B12 on the market contains Cyanide. However because it's bound to cobalamin (B12) it's about 1000x safer than Cyanide. Now this could be in part due to the fact that B12 is a huge molecule and Cyanide is small, but Cyanide has a molecular weight of 26 g/mol and B12 has a molecular weight of 1355, which means cyanide accounts for 1/50th, or 2% of the weight. Now if it was safer ONLY because it accounted for 1/50th of it's weight, you'd expect it to be 50 time safer, not 1000. Another thing, the IUPAC name of Vitamin B12 is a-(5,6-dimethylbenzimidazolyl)cobamidcyanide, and I've seen the cyanide actually separate in the longer version of the name, separated with a semicolon. Now I don't know if this means the Cyanide is more dinstinct than Acrylamide is in Acrylfentanyl, but I thought it was interesting to note.
Keep in mind
I HAVE ABSOLUTELY NO FORMAL EXPERTISE/EDUCATION IN THIS SUBJECT OTHER THAN INTERNET RESEARCH With that being said, I thought I'd share my research/thoughts/assumptions with others looking into Acrylfentanyl. According to Wikipedia (the fentanyl entry I believe where it lists analogs) it was created by an Egyptian scientist, although
there is no citation for this information. I doubt an Egyptian Scientist, who is probably not just trying to skirt the law for profit by making new analogs like Chinese chemists where this stuff is produced, would create this knowing it would be carcinogenic, as I'm sure he knows that the uses for fentanyl analogs are consumption, not adhesives and such. Keep in mind though, the vast majority of
my reasoning is based on assumptions that I only have a very shallow knowledge of. I'm not advocating for its use, but thought it'd be worth sharing.
I'd really love it if someone who is more knowledgeable on the subjects of chemistry, pharmacology, and other related subjects would chime in and tell me where my reasoning is acceptable and where it is completely flawed. Thanks.