The Hypnotist
Bluelighter
- Joined
- Feb 1, 2016
- Messages
- 381
I would like to know how much cross-tolerance has 5-MeO-DMT, if any. I read in PsychonautWiki that "5-MeO-DMT does not have a cross-tolerance with other psychedelics, meaning that after the consumption of 5-MeO-DMT psychedelics will not have a reduced effect".
A friend that had an experience with Bufo Alvarius hours before of an Ayahuasca ceremony thought the 5-MeO-DMT didn't interfere with it and thought to have had full effects from both.
So I went on searching and the only thing I could find was an old post from Solipsis (who else?) where he was refering to a study where it was mentioned that 5-MeO-DMT has 9 times more afinity for the 5-HT1A receptor. So that kind of will explain it.
My question is if there is not a bit of tolerance as it has some activity in the 5-HT2A.
And I would like to know too if other single tryptamines are producing less cross-tolerance than more complex psyquedelics. And how long are the estimated wait time for reseting tolerance. I heard people saying to have been smoking DMT during experiences with other psychedelics, so maybe it doesn't affect it...My guts tell me that the shorter acting the less tolerance they will produce...but I might think that just because of DOC strong cross-tolerance IME.
A friend that had an experience with Bufo Alvarius hours before of an Ayahuasca ceremony thought the 5-MeO-DMT didn't interfere with it and thought to have had full effects from both.
So I went on searching and the only thing I could find was an old post from Solipsis (who else?) where he was refering to a study where it was mentioned that 5-MeO-DMT has 9 times more afinity for the 5-HT1A receptor. So that kind of will explain it.
My question is if there is not a bit of tolerance as it has some activity in the 5-HT2A.
And I would like to know too if other single tryptamines are producing less cross-tolerance than more complex psyquedelics. And how long are the estimated wait time for reseting tolerance. I heard people saying to have been smoking DMT during experiences with other psychedelics, so maybe it doesn't affect it...My guts tell me that the shorter acting the less tolerance they will produce...but I might think that just because of DOC strong cross-tolerance IME.
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