Hi there,
First of all, sorry if this has been posted elsewhere! I've done searches and tried to built up some info on 5HT2b agonism, but am sure you more chestry-aware people could help!
A friend offered me a "neo dove" and because i'm a bit of a girl when it comes to drugs, i turned them down, as i like to look after my body!
I did some research and found out they contain 4-methyl-methcathione/mephedrone, and apparently it's the addition of alkyl halide substitutions in the 4 category (referring to 4-methyl?) that make the otherwise non-5HT2b-agonistic methcathion into an agonist!
My understanding of 5HT2b agonists derives from the slimming drug fenfluramine, which spent 25 years on the market (73-98?) before being withdrawn due to links with heart valve problems (due to there being lots of 5HT2b receptors in the heart cells, and hence they divide rapidly when in contact with an agonist).
The stats i read on that were worrying. with about 25% of people on the drug for 3-12 months having heart problems! And this is what worries me about my friend taking "neo doves".
Is it dangerous for someone to take one or two of these every two weeks or maybe even each week?
After 3 months or so of taking one each week, could you be susceptible to similar heart damage of fenfluramine patients? Or is it the fact that they took this fenfluramine every day for months on end that caused the mutations, and hence recreational use, and recreational doses will have little effect on the heart valves. After all, isn't MDMA (3,4-methylenedioxymethamphetamine) also posession a alkyl halide in the 4 position?
I read a couple of reports somewhere saying MDMA was similarly a 5HT2b agonist! Based around a study done on heart cells, which was monitored, and the results showed that it caused similar growth to those mixed with fenfluramine.
SO, MDMA hasn't caused much of a heart stir up, and it was introduced to the majority at the same time as fenfluramine (give or take a few years). Does this mean that it's only chronic usage that can result in heart valve conditions, and hence taking it once a fortnight won't have much of a long term problem?
ALSO, can this 4-Methyl-methcathione perhaps have a greater affinity to the 5HT2b receptors than Fenfluramine, and MDMA, making it very hard to judge how dangerous it is?
And finally, is the damage caused relative more-so to :
-Taking a high dose (10 capsules a night, if thats possible?) yet only doing them once every 2 months
OR
-Taking 1-2 capsules every 1-2 weeks
Sorry for a strange and possibly repetative question! But this has just caught my interest, as i want to try one, but am not sure of the dangers for both me, and my much more reckless friend, who has never had a second thought about what they consume >.<
Thanks!
First of all, sorry if this has been posted elsewhere! I've done searches and tried to built up some info on 5HT2b agonism, but am sure you more chestry-aware people could help!
A friend offered me a "neo dove" and because i'm a bit of a girl when it comes to drugs, i turned them down, as i like to look after my body!
I did some research and found out they contain 4-methyl-methcathione/mephedrone, and apparently it's the addition of alkyl halide substitutions in the 4 category (referring to 4-methyl?) that make the otherwise non-5HT2b-agonistic methcathion into an agonist!
My understanding of 5HT2b agonists derives from the slimming drug fenfluramine, which spent 25 years on the market (73-98?) before being withdrawn due to links with heart valve problems (due to there being lots of 5HT2b receptors in the heart cells, and hence they divide rapidly when in contact with an agonist).
The stats i read on that were worrying. with about 25% of people on the drug for 3-12 months having heart problems! And this is what worries me about my friend taking "neo doves".
Is it dangerous for someone to take one or two of these every two weeks or maybe even each week?
After 3 months or so of taking one each week, could you be susceptible to similar heart damage of fenfluramine patients? Or is it the fact that they took this fenfluramine every day for months on end that caused the mutations, and hence recreational use, and recreational doses will have little effect on the heart valves. After all, isn't MDMA (3,4-methylenedioxymethamphetamine) also posession a alkyl halide in the 4 position?
I read a couple of reports somewhere saying MDMA was similarly a 5HT2b agonist! Based around a study done on heart cells, which was monitored, and the results showed that it caused similar growth to those mixed with fenfluramine.
SO, MDMA hasn't caused much of a heart stir up, and it was introduced to the majority at the same time as fenfluramine (give or take a few years). Does this mean that it's only chronic usage that can result in heart valve conditions, and hence taking it once a fortnight won't have much of a long term problem?
ALSO, can this 4-Methyl-methcathione perhaps have a greater affinity to the 5HT2b receptors than Fenfluramine, and MDMA, making it very hard to judge how dangerous it is?
And finally, is the damage caused relative more-so to :
-Taking a high dose (10 capsules a night, if thats possible?) yet only doing them once every 2 months
OR
-Taking 1-2 capsules every 1-2 weeks
Sorry for a strange and possibly repetative question! But this has just caught my interest, as i want to try one, but am not sure of the dangers for both me, and my much more reckless friend, who has never had a second thought about what they consume >.<
Thanks!