You seem quite sensitive to the effects, so start with a ~5 mg dose rectally. That'll be more intense than 6 mg oral, but almost surely with less dysphoria and nausea. Put 5 ml warm water in a shot glass with the dose of 2C-E, agitate it till it all dissolves, suck it up in a syringe (without needle of course), make sure your bowels are relatively clean, use a water-based lubricant like Wet (there's a chance an oil-based lube could coat your colon a bit, reducing surface area), and inject it well past your sphincters (4 inches deep is good, or about the length of the shaft of a 10 ml syringe--remember you have two sphincters to make it past). None should leak. Lay down with a book and read over the course of the next 30 minutes or so and the solution will be fully absorbed by the lining.
Something else that will probably improve the experience is weed. For me, it transforms a general discomfort or feeling of uneasiness into a consistent state of euphoria. It shouldn't cloud your mind.