Oral tetrahydroharmine + sublingual HPBCD DMT journeys, very similar to mescaline - Pharmahuasca - Welcome to the DMT-Nexus
For next journey two weeks from now, will do the following again:
I want to simulate what happened back in late June, it was a sublingual HPBCD DMT experience that I fell in love with.
I used the formula below, and had 90 minutes of open eyed visuals that were extremely powerful, WILD open eyed visuals: geometrics on the walls, neon colors flashing in the air, concentric colored circles in the air, everything surrounded by a neon rainbow aura of colors.
There was a curtain of visuals when moving from one room to the next in the doorway. Open-eyed profound beauty enhancement and diamond-like sparkling & shimmering surrounding the actresses on TV who looked like dazzling, glowing, super-colorful cartoon versions of themselves, exceptionally colorful. Music enhancement extremely powerful. Felt like 600mg to 700mg of mescaline.
Again, there was no anxiety, no nausea, no dizziness, very pleasurable experience.
Not only that, but when I re-dosed again with the same dosage (another 20mg HPBCD harmine + 90mg HPBCD DMT) it came back again full-force, same strength and same duration of remarkable open eyed visuals.
1. first took 300mg THH orally in a capsule.
2. then took all this sublingually: 20mg harmine freebase complexed to 120mg HPBCD in a few drops of water under tongue along with 90mg DMT freebase complexed to 630mg HPBCD in 10 drops of water.
The 20mg sublingual harmine has the power of 120mg oral harmine, which is plenty to slow down the inactivation of the DMT by MAO, localized in the mitochondria within the neuron in the brain...this allows the sublingual HPBCD DMT to be VERY STRONG and LAST for a LONG DURATION.
HPBCD = Hydroxypropyl-beta-cyclodextrin
2-HPBCD = 2-hydroxypropyl-beta-cyclodextrin
Note: Molecular weight of harmine = 212g/mol, plain HPBCD molecular weight = 1300g/mol, therefore use a 1:6g weight ratio in order to keep a 1:1 molar ratio. 2-HPBCD = 1500g/mol, therefore use a 1:7g weight ratio in order to keep a 1:1 molar ratio.
Note: Molecular weight of DMT = 188g/mol, plain HPBCD molecular weight = 1300g/mol, therefore, use a 1:7g weight ratio in order to keep a 1:1 molar ratio. 2-HPBCD = 1500g/mol, therefore use a 1:8g weight ratio in order to keep a 1:1 molar ratio.
Using tiny dose harmine sublingually acts more as a facilitator than a participant. It does not bother me and nothing like when I use it orally, it's very tolerable, no weirdness, sedation, etc. I'm not a big fan of oral harmine even at 150mg.
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Complete short summary:
So the deal is that HPBCD makes the non-water soluble freebase DMT water soluble. It traps and delivers small molecules such as DMT extremely effectively across the mucosa membrane under the tongue, with it's high permeability (only 100 to 200 micrometers thick) and rich blood supply--shuttling the DMT directly to bloodstream, where it penetrates past the sublingual mucosa as the potent freebase into the bloodstream, where it reaches the brain with amazing strength.
The 150mg to 300mg THH taken orally 45 minutes before beginning the sublingual phase will double the half-life of the DMT, but also...as little as 20mg sublingual harmine in combo with the sublingual HPBCD DMT has the power of 120mg oral harmine, which is plenty to slow down the deamination of the DMT by MAO, localized in the mitochondria within the neuron in the brain...this allows the sublingual HPBCD DMT to be VERY STRONG and LAST for a LONG DURATION.
See journey report above from late June: The above formula allows for 90 minutes of wild amazing open-eyed visuals, very strong music enhancment & over the top beauty enhancment.
Just as Jonathan Ott reports, the oral or sublingual dose is about half the potency of inhaled smoke vapor. The sublingual HPBCD DMT dose comes on in only half the time of oral DMT (22 minutes instead of 45 minutes) but still lasts as long as an oral dose (90 minutes).
There are countless reports and threads here of people trying plain sublingual DMT freebase and DMT salts sublingually, and just not getting any effects, however, complexing the DMT freebase to the HPBCD will allow it to absorb at near 100% efficiency sublingually in my experience.
This is very similar to how chemist Patrick Arnold made non-water soluble pro-hormones that converted in the body via enzyme activity to 95% testosterone absorb at near 100% efficiency sublingually as well. It worked so well, he created a company called ERGOPHARM that made millions selling these patented cyclo-diol (hydroxy propyl beta cyclodextrin complexed pro-hormones) to body-builders for a decade until they were made illegal, these sublingual HPBCD complexed pro-hormones worked extremely well when taken sublingually. It worked so well, the pharmaceutical companies later picked up on his idea and started marketing sublingual HPBCD testosterone to hypogonadal men, and according the the published studies I have read on-line it worked like a gem to raise all of the men's testosterone levels to the high-normal (1100 to 1200ng/dl).
In 2001 Arnold's company introduced the prohormone 4-Androstenediol, under the marketing name 4-AD. 4-AD is a prohormone that is easily converted by the body into testosterone, and it sold well. He is the chemist who created hydroxypropyl-beta-cyclodextrin complexed diols such as Cyclo-Diol(TM) and Cyclo-Nordiol(TM) to be used sublingually under the tongue.
hxxps://thinksteroids.com/articles/ask-patrick-arnold-11/
I bought and used these over the counter sublingual HPBCD pro-hormones, had my testosterone level checked 30 minutes later at a bloodwork lab, and it sored from my low normal 300ng/dl to a whopping 1500ng/dl, well above the high normal of 1100 ng/dl in gifted men.
I've done this sublingual DMT over 33 times if you count the number of times I've re-dosed in an evening, always two more re-doses every 1.5 hour for a 4.5 hour long trip with super long afterglow.
What I began to notice, later on when I introduced a tiny amount of sublingual harmine to the sublingual DMT, thanks to the writings of Loveall, Jamie, amor_fati, Gibralter, and others...
...all held under the tongue at the exact same time, is that complexing the 20mg harmine to 120mg HPBCD in 3 drops boiling hot water masked the nasty taste of the harmine better than just using the plain harmine freebase sublingually. The HPBCD also helps the harmine freebase absorb better than normal.
See trip report above, the tiny sublingual harmine dose potentiated the already strong sublingual HPBCD DMT to un-heard of incredible strength and duration, my preferred method of using it.
Jamie, posted : 11/23/2012 8:29:28 PM:
You cant compare sublingual or oral either..20-30mg sublingual is enough to activate sublingual DMT and cause effects on it's own. 20mg sublingual is probably comparable to 200mg oral.
Dr. Narang and Sharma in attached paper on post #2 at dmt nexus mention in their 2010 sublingual paper that under the tongue pharmaceuticals can be 3 to 10 times more bioavailable than oral.
In my estimation, sublingual harmine is "at least" x6 times as powerful as oral (3+10 divided by 2 = avg of x6), therefore 20mg is at least as powerful as 120mg oral harmine, which is the threshold oral dose (1.5mg/kg) that Jonathan Ott found to easily activate 35mg doses of DMT and above. His weight is 175lbs.
I have had +5 Shulgin experiences with just the plain sublingual HPBCD DMT, taking of course 300mg THH 45 minutes before beginning the sublingual HPBCD DMT phase of course.
But the addition of the tiny dose sublingual HPBCD harmine along with the sublingual HPBCD dmt just takes this all to soring new levels of strength and duration, a full 90 minutes of "over the top" potent open-eyed visuals, all recounted on post #5.
Music will blow you away, heard as if you were an alien experiencing sound and music for the very first time, every instrument stands out on it's own...just heavenly. The same exact powerful music enhancment that high dose Bolivian bridgesii, Peruvian torch, san pedro cactus tea imparts on it's drinkers.
Besides the potent visuals & music enhancement, beauty enhancement is way over the top and infinite.
Yes, the HPBCD DMT will work sublingually without the THH, but it's not anything like mescaline when used without the THH, colors are dark, music is not enhanced, euphoria not apparent, beauty enhancement is not over the top, half life is not doubled, short lasting, etc.
In conclusion, the importance of tetrahydroharmine (THH) for those who just started reading:
1. Part 10 of the first paper: shows how to convert harmaline to pure THH in 1.5 hour for the first time (very fast) with 75% yield. Post also shows how to check the blue glow under blacklight to make sure it is pure. Any green or yellow in the glow means you still have un-converted harmaline, but follow instructions and you won't have any unconverted. It is the 2nd highest ingredient in Caapi based true Ayahuasca.
THH has a 10.5 hour half-life with peak at 5.25 hours, so you only need dose it once, as it lasts all evening in combo with the HPBCD DMT sublingual doses, which I re-dose under-tongue from a storage syringe (explained on post #1) every 1.5 hour twice more beyond original dose to keep the journey super-strong for many hours.
As a chemist, I only use my own pure home-made THH, I have no idea about any other THH out there. If you use THH you don't make yourself, at least grab some of it on a wet cue tip and smear it on a paper plate and hold in front of blacklight, if it glows solid light blue, it is THH, but keep in mind harmine also glows same color. THH also has a lingering metallic like taste when smeared onto tongue.
Any green or yellow in the glow indicates unconverted harmaline, how much is anyones guess, could be a tiny bit or alot. Harmaline at least for me can cause dizziness, nausea, sick feelings, sleepiness with short period of re-bound insomnia the next night...depending on how much of it there is.
2. Dennis Mckenna Ph.D: page 115 "Thus, tetrahydroharmine may prolong the half-life of DMT by blocking it's intraneuronal uptake, and hence, its inactivation by MAO, localized in mitochondria within the neuron." In my experience, THH doubles the half-life of DMT, so when used sublingually or orally, you get a full strong 90 minutes out of it with long afterglow.
3. DMT only colors are subdued and dark, but THH brightens the DMT visuals: out of this world impossible bright neon colors are a trait of high dose oral tetrahydroharmine + moderate dose 60 to 70mg+ sublingual or oral HPBCD DMT: neon red-greens, neon orange-blues, neon purple-yellows.
4. DMT does not block serotonin on it's own, but THH does...this results in not only stimulation but euphoria in combo with the DMT: and real Ayahuasca visions become apparent which can be seen for hours on end...important teamwork. Ibogaine, LSD, mescaline, shrooms, 5-meo-dmt, bufotenin in Amazonian snuffs, all block serotonin, THH blocks serotonin. See receptorome chart located on part I paper.
5. THH has numerous similarities to mescaline, not only does it block serotonin like mescaline, LSD & shrooms, but it agonizes all 3 adrenal receptors just like mescaline, which are associated with beauty & aesthetics appreciation, beauty enhancement is "over the top" when THH is included. Actresses on TV will look like dazzling glowing super-colorful cartoon versions of themselves (just like with high dose cactus tea) only if you include the THH. Researchers have called THH the "tryptamine of the beta-carboline world" and rightly so.
6. THH is found in average 150mg in a cup of Caapi based Ayahuasca tea, see Dennis Mckenna ph.D. paper on post #2. when 2 cups are drank by more advanced members for evening at the vegetals, those advanced people are consuming around 300mg of THH. As a beginner, always stick with 150mg of THH or similar, I like to think of it like this:
150mg of acid is a good medium dose, 150mg of THH is a good medium dose.
200mcg of acid is a strong dose, 200mg of THH is a strong dose.
250mcg of acid is a very potent dose, 250mg of THH is a very potent dose.
300mcg of acid is heavy strong dose, 300mg of THH is heavy strong dose.
7. Music will only sound bad-ass incredible if you include from 150mg to 300mg oral THH with your sublingual or oral DMT. The music enhancment of THH + DMT is just extraordinary, music lovers like myself will delight for hours on end.
In conclusion, I've taken Ayahuasca over 80 times now, cactus tea over 200 times, I've noticed recently that much of the bridgesii I used to love and cherish (my favorite cactus drink) has become nearly extinct and what does remain is super expensive. Even san pedro, which can be all over the place potency wise, has become very expensive. You can spend a small fortune only to discover it is very potent, or only slightly above threshold.
Was thrilled to discover this sublingual HPBCD DMT in combo with oral THH, (thanks to the help of an Ayahuasca vision recounted in 1st paper on post #53) as it gives me identical effects as high dose bridgesii cactus tea, infinitely beautiful, brilliantly penetrating, no sedation, long 4.5 hour trip (so long as I keep sublingual HPBCD DMT re-dosing every 1.5 hour) with long-lasting afterglow.