I should add that once you have these very fresh just extracted and complexed pre-made frozen syringes made, each with 0.6ml (110mg HPBCD DMT) that they can not only be used under the tongue sublingually, but can just as easily be used in an Ayahuasca tea...
What I have done before is squirt all 110mg HPBCD DMT directly into a 1oz black coffee that already has 140mg of harmine freebase dissolved into it with a bit of crushed vit C, so the harmine freebase dissolves. YES! I have used as little as 140mg harmine freebase to activate the dmt, just as Jonathan Ott found out works (1.5mg/kg threshold activating dose). He found 120mg worked just fine for him, he weighs 175lbs (80kg), I weigh 200lbs (90kg).
I take a capsule of from 150mg to 300mg THH orally around the same time. You can re-dose again later with sublingual HPBCD DMT under the tongue every 1.5 hour, the oral harmine continues to work for 5 hours, to slow down the deamination or oxidation of the DMT in the mitochondria in the brain. I have tripped very hard all evening long (4.5 hours) this way.
There are options is all I'm saying: sublingual or oral.
----------------------------------------------------------------------
The end summary. Von Voyage.
pic5: 2.2g fresh new extracted DMT from 170g bark & 20 x 3ml syringes each getting ready to be loaded with 0.6ml = 110mg HPBCD DMT
pic6: 20 syringes each holding 110mg HPBCD DMT for sublingual or oral use, storage in freezer will keep potent indefinitely. I like to use 3 for the evening, 300mg oral THH 45 minutes before, then pull out one syringe holding 110mg HPBCD DMT original dose, squirt under tongue and hold for 15 minutes, and re-dose every 1.5 hour, for 3 total doses = 4.5 hour of very strong effects, identical to 500 to 700mg long lasting mescaline.
pic7: store 20 syringes in freezer in a protein shaker bottle, "syringe tip caps", 1000 for dirt cheap, go on the end to seal syringe, so no leak.
Or can be used by taking from 150mg to 300mg THH in a capsule, then take an Ayahuasca tea made with 1oz hot coffee holding from 140 to 180mg harmine freebase with a bit of vitamin C added to help the harmine absorb should it be in freebase form, then squirt the syringe dosage into the hot 1oz coffee, mix and drink all at the exact same time, just as the Shaman's do. The oral HPBCD DMT is very potent, much stronger than normal DMT freebase or salts used orally, and just as strong as actual 30 to 40g Hawaiian psychotria.
-----------------------------------------------------------------------------------------
How to:
110mg fresh just extracted DMT is put onto a spoon, covered with (1:7g ratio to keep at a 1:1 molar ratio) 770mg plain HPBCD, if using instead the 2-HPBCD, then use a 1:8g weight ratio or 880mg 2-HPBCD in order to keep a 1:1 molar ratio.
Then 12 drops of near boiling hot water from a nearby coffee mug is added, mix, mash & scrape it all back and forth on the spoon, using the end of another spoon really hard using your muscles for 2 minutes, then suck up the 0.6ml (12 drop complex) into a 3ml syringe for storage in a freezer, keeps the fresh potency forever, the DMT protected within the HPBCD cavity, and frozen solid, never oxidizes this way, stays as fresh as the day you extract it.
So on the day I extract 2.5g from 170g bark, I go ahead and right after scraping it all up, and allowing it to dry, pre-prepare many individual syringes, and freeze all of them, each with a 0.6ml 110mg HPBCD DMT dose.
If you take a look at the 3ml syringe picture, notice 12 drops fills it up to 6th click mark.
tic mark 1 = 2 drops = 18.3mg HPBCD DMT (0.1ml)
tic mark 2 = 4 drops = 36.3mg HPBCD DMT (0.2ml)
tic mark 3 = 6 drops = 54.9mg HPBCD DMT (0.3ml)
tic mark 4 = 8 drops = 73.2mg HPBCD DMT (0.4ml)
tic mark 5 = 10 drops = 91.5mg HPBCD DMT (0.5ml)
tic mark 6 = 12 drops = 110mg HPBCD DMT (0.6ml)
This is how I measure my dosage out for sublingual or oral Ayahuasca use, once I pull the syringe from the freezer, it will quickly defrost at room temp. You can either shoot the dose directly under your tongue, or measure out the dose onto a spoon, then place the bottom side of your tongue onto the spoon, and it will all adhere. Then simply hold dose under tongue, and press it into the sublingual mucosa, it will all dissolve in 15 minutes or less.
Stay true to yourself. Love, Peace & Music
http://friskyradio.com
From much experience, can indeed say that THH is very euphoric and creates open-eyed visual "over the top visual beauty enhancement". Hours of closed eye teaching visions when I reach 300mg of pure THH. Note the 300mg dosage entry for THH or tetrahydroharmine in TIHKAL was not done by Dr. Shulgin but by an inexperienced person who equated it to 100mg harmaline. Tetrahydroharmine is nothing like harmaline, it is not sedating or nauseating or even dizzying, but rather stimulating, euphoric, very mescaline-like with diamondlike open eyed beauty enhancement, music enhancement, closed eye way beyond 4k teaching visions for hours on end, it's in the same beta-carboline family as ibogaine.
THH has 10.5 hour half-life with peak at 5.25 hours. When 150mg to 200mg THH is combined with DMT either sublingually or in an Ayahuasca tea with from 140 to 180mg harmine fb, the effects are absolutely stunning, very much identical to high dose mescaline, mescaline like euphoria for hours on end, deep head space, powerful music enhancement, powerful spiritual insights and visions, etc.
THH is an isomer of a hormonal-like substance found in the brain already, and is responsible for the teaching visions and Ayahuasca's telepathic or telepathine properties. I believe it is the "main course" of the Ayahuasca session, it is also able to bring out the "essence" of other plants, and combines extremely well with all sorts of psychedelics to bring out there "essence".
Historical note: one month ago combined 300mg of THH or tetrahydroharmine with 250mcg of acid paper that had been soaked in 1 shot of cold sherry wine for 3 hours in the fridge with hand stirring once an hour in the fridge, to help theoretically or hypothetically convert the LSD to the more colorful & visual and head-space gentle ALD-52 by adduction of the acetaldehyde from the sherry wine to the NH bottom indole position on the LSD (don't try this at home unless you are really advanced, and sure you have very pure THH) and had closed eye bright colored teaching visions all the way from 8pm till midnight.
Much more powerful than LSD visions alone, these were brightly colored Ayahuasca visions. One of the sequence of visions were of a variety of stone carvings with very elaborate artwork and a beautiful woman who stretched out her hand to me to show me magic.
I would need a tape recorder going as I lie in bed for hours to talk into in order to record the hundreds of non-stop animated and static colored visions.
Then at midnight took another 100mg of THH, it brought the visions all back until 4am in the morning! It was almost too much, non-stop hundreds of Ayahuasca visions for hours and hours, I was completely blown away, reminds me of the time I took 300mg THH combined with 60mg sublingual HPBCD DMT every 1.5 hour and had visions from midnight all the way till 5am in the morning also. I would lie in bed watching the colored visions for hours on end listening to music on my headphones, which sounded as if I had taken a high dose cactus tea, very remarkably enhanced, just Heavenly.
The combo of 300mg THH + LSD also makes the beauty & aesthetic enhancement way stronger than LSD alone, and the music sounds much better than LSD alone, it feels very much like when you combine mescaline with LSD, as THH is like the beta-carboline version of mescaline. Very beautiful combination.
Please note: all beginners only use around 150mg to 200mg THH which is what is found average in 1 cup of Ayahuasca tea, only advanced members of the UDV, Santo Daime, Shuar Indian and people like myself drink 2 cups of Ayahausca tea for the evening, which then contains around 300mg THH average.
P.S. Will be able to determine in future whether coffee filters or a cotton ball stuffed into a funnel will work in place of normally used vacuum pump with #101 filtration disc to filter out the remaining floating zinc dust (only around 10% left floating) after the spun solution sits for 1 hour as 90% of the zinc dust falls to very bottom, so solution above it can be decanted off. This would make it very cost efficient and easy for anyone to convert harmaline to THH without all the fancy equipment (buchner filtration flask and cup/filtration paper, vacuum pump).
1st paper: HPBCD DMT very bioavailable sublingually under tongue, combo with tetrahydroharmine, Ayahuasca
Harmaline to THH in 1.5 hour, way a chemist does it, see post #12: https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=96861
2nd paper: Oral Tetrahydroharmine + sublingual HPBCD DMT journeys, very similar to mescaline:
Oral tetrahydroharmine + sublingual HPBCD DMT journeys, very similar to mescaline - Pharmahuasca - Welcome to the DMT-Nexus
-----------------------------------------------------------
Update: Now we know why polysaccharides like those in aloe vera leaf and gel or the man-made polysaccharides like HPBCD increase the oral and sublingual absorption of DMT freebase by many factors:
Downwardsfromzero said a while back:
This explains how when HPBCD is complexed to freebase DMT, it is able to not only make it water soluble, but also make it absorb MANY FACTORS BETTER orally than normal DMT freebase or DMT salts.
This is why in my experience, the Ayahuasca tea made with HPBCD DMT is many factors stronger than normal DMT, easy to reach +5 Shulgin strength levels, just like the Hawaiian psychotria made Ayahuasca tea, which in all likely hood may also contain polysaccharides just like aloe vera leaf which explains why the Hawaiian psychotria leaf contained DMT easily reaches +5 Shulgin strength: all encompassing and super-strong. I've taken Hawaiian psychotria over 70 times in Ayahuasca made Caapi tea, and it's always been super potent, much more potent than freebase used DMT or salts in my experience. A world of difference, no comparison. The HPBCD DMT is the same, super potent just like the Hawaiian leaf.
Example from the scientific literature: HPBCD improves oral absorption profile for Ofloxacin, a second generation fluroquinolones by 54 to 89 percent.
Guess what else also contains polysaccharides: Aloe vera gel and leaf. Aloe vera gel caused a 3.7 fold increase in the bioavailability of vitamin C in comparison to control (vitamin C administered in water).
The polysaccharide fraction from dehydrated Aloe vera gel (datonmax 700) material could enhance the transport of many drugs across the intestinal rat tissue many factors over, and was statistically significant compared to control.
Aloe vera leaf and gel, due to the polysaccharides open tight junctions and consequently enhance paracellular transport of hydrophilic molecules.
Polysaccharides are the component of aloe vera gel and leaf that is the biologically active component responsible for the greatly increased modulation of drug pharmacokinetics and absorption -- this is concentrated in the polysaccharide components of the aloe vera gel and material.
The paper also shows that Aloe vera has also been shown to significantly enhance the sublingual and buccal permeability of drugs. HPBCD complexed freebase DMT does the same thing, it not only makes the DMT water soluble until it crosses the sublingual membrane, where it is released into the bloodstream as the potent freebase, where it reaches the brain intact in my experience, very potent indeed...
...but HPBCD, being a polysaccharide just like aloe vera gel or leaf, greatly enhances the penetration of the DMT thru the sublingual mucosa under the tongue due to it's potent disruption capabilities of the epithelium layer (only 100 to 200um thick), also discussed in the attached paper.
All of this is covered in the attached paper "Drug Bioavailability Enhancing Agents of Natural Origin (Bioenhancers) that Modulate Drug Membrane Permeation and Pre-Systemic Metabolism" by Bianca Peterson, Morné Weyers , Jan H. Steenekamp, Johan D. Steyn, Chrisna Gouws and Josias H. Hamman.
Last pic: The absorption of drugs through the sublingual mucosa route is 3 to 10 times greater than oral route according to Dr. Narang.
Pharmaceutics drug bioavailability enhancing agents (1).pdf 2.19MB 3 downloads
What I have done before is squirt all 110mg HPBCD DMT directly into a 1oz black coffee that already has 140mg of harmine freebase dissolved into it with a bit of crushed vit C, so the harmine freebase dissolves. YES! I have used as little as 140mg harmine freebase to activate the dmt, just as Jonathan Ott found out works (1.5mg/kg threshold activating dose). He found 120mg worked just fine for him, he weighs 175lbs (80kg), I weigh 200lbs (90kg).
I take a capsule of from 150mg to 300mg THH orally around the same time. You can re-dose again later with sublingual HPBCD DMT under the tongue every 1.5 hour, the oral harmine continues to work for 5 hours, to slow down the deamination or oxidation of the DMT in the mitochondria in the brain. I have tripped very hard all evening long (4.5 hours) this way.
There are options is all I'm saying: sublingual or oral.
----------------------------------------------------------------------
The end summary. Von Voyage.
pic5: 2.2g fresh new extracted DMT from 170g bark & 20 x 3ml syringes each getting ready to be loaded with 0.6ml = 110mg HPBCD DMT
pic6: 20 syringes each holding 110mg HPBCD DMT for sublingual or oral use, storage in freezer will keep potent indefinitely. I like to use 3 for the evening, 300mg oral THH 45 minutes before, then pull out one syringe holding 110mg HPBCD DMT original dose, squirt under tongue and hold for 15 minutes, and re-dose every 1.5 hour, for 3 total doses = 4.5 hour of very strong effects, identical to 500 to 700mg long lasting mescaline.
pic7: store 20 syringes in freezer in a protein shaker bottle, "syringe tip caps", 1000 for dirt cheap, go on the end to seal syringe, so no leak.
Or can be used by taking from 150mg to 300mg THH in a capsule, then take an Ayahuasca tea made with 1oz hot coffee holding from 140 to 180mg harmine freebase with a bit of vitamin C added to help the harmine absorb should it be in freebase form, then squirt the syringe dosage into the hot 1oz coffee, mix and drink all at the exact same time, just as the Shaman's do. The oral HPBCD DMT is very potent, much stronger than normal DMT freebase or salts used orally, and just as strong as actual 30 to 40g Hawaiian psychotria.
-----------------------------------------------------------------------------------------
How to:
110mg fresh just extracted DMT is put onto a spoon, covered with (1:7g ratio to keep at a 1:1 molar ratio) 770mg plain HPBCD, if using instead the 2-HPBCD, then use a 1:8g weight ratio or 880mg 2-HPBCD in order to keep a 1:1 molar ratio.
Then 12 drops of near boiling hot water from a nearby coffee mug is added, mix, mash & scrape it all back and forth on the spoon, using the end of another spoon really hard using your muscles for 2 minutes, then suck up the 0.6ml (12 drop complex) into a 3ml syringe for storage in a freezer, keeps the fresh potency forever, the DMT protected within the HPBCD cavity, and frozen solid, never oxidizes this way, stays as fresh as the day you extract it.
So on the day I extract 2.5g from 170g bark, I go ahead and right after scraping it all up, and allowing it to dry, pre-prepare many individual syringes, and freeze all of them, each with a 0.6ml 110mg HPBCD DMT dose.
If you take a look at the 3ml syringe picture, notice 12 drops fills it up to 6th click mark.
tic mark 1 = 2 drops = 18.3mg HPBCD DMT (0.1ml)
tic mark 2 = 4 drops = 36.3mg HPBCD DMT (0.2ml)
tic mark 3 = 6 drops = 54.9mg HPBCD DMT (0.3ml)
tic mark 4 = 8 drops = 73.2mg HPBCD DMT (0.4ml)
tic mark 5 = 10 drops = 91.5mg HPBCD DMT (0.5ml)
tic mark 6 = 12 drops = 110mg HPBCD DMT (0.6ml)
This is how I measure my dosage out for sublingual or oral Ayahuasca use, once I pull the syringe from the freezer, it will quickly defrost at room temp. You can either shoot the dose directly under your tongue, or measure out the dose onto a spoon, then place the bottom side of your tongue onto the spoon, and it will all adhere. Then simply hold dose under tongue, and press it into the sublingual mucosa, it will all dissolve in 15 minutes or less.
Stay true to yourself. Love, Peace & Music
http://friskyradio.com
From much experience, can indeed say that THH is very euphoric and creates open-eyed visual "over the top visual beauty enhancement". Hours of closed eye teaching visions when I reach 300mg of pure THH. Note the 300mg dosage entry for THH or tetrahydroharmine in TIHKAL was not done by Dr. Shulgin but by an inexperienced person who equated it to 100mg harmaline. Tetrahydroharmine is nothing like harmaline, it is not sedating or nauseating or even dizzying, but rather stimulating, euphoric, very mescaline-like with diamondlike open eyed beauty enhancement, music enhancement, closed eye way beyond 4k teaching visions for hours on end, it's in the same beta-carboline family as ibogaine.
THH has 10.5 hour half-life with peak at 5.25 hours. When 150mg to 200mg THH is combined with DMT either sublingually or in an Ayahuasca tea with from 140 to 180mg harmine fb, the effects are absolutely stunning, very much identical to high dose mescaline, mescaline like euphoria for hours on end, deep head space, powerful music enhancement, powerful spiritual insights and visions, etc.
THH is an isomer of a hormonal-like substance found in the brain already, and is responsible for the teaching visions and Ayahuasca's telepathic or telepathine properties. I believe it is the "main course" of the Ayahuasca session, it is also able to bring out the "essence" of other plants, and combines extremely well with all sorts of psychedelics to bring out there "essence".
Historical note: one month ago combined 300mg of THH or tetrahydroharmine with 250mcg of acid paper that had been soaked in 1 shot of cold sherry wine for 3 hours in the fridge with hand stirring once an hour in the fridge, to help theoretically or hypothetically convert the LSD to the more colorful & visual and head-space gentle ALD-52 by adduction of the acetaldehyde from the sherry wine to the NH bottom indole position on the LSD (don't try this at home unless you are really advanced, and sure you have very pure THH) and had closed eye bright colored teaching visions all the way from 8pm till midnight.
Much more powerful than LSD visions alone, these were brightly colored Ayahuasca visions. One of the sequence of visions were of a variety of stone carvings with very elaborate artwork and a beautiful woman who stretched out her hand to me to show me magic.
I would need a tape recorder going as I lie in bed for hours to talk into in order to record the hundreds of non-stop animated and static colored visions.
Then at midnight took another 100mg of THH, it brought the visions all back until 4am in the morning! It was almost too much, non-stop hundreds of Ayahuasca visions for hours and hours, I was completely blown away, reminds me of the time I took 300mg THH combined with 60mg sublingual HPBCD DMT every 1.5 hour and had visions from midnight all the way till 5am in the morning also. I would lie in bed watching the colored visions for hours on end listening to music on my headphones, which sounded as if I had taken a high dose cactus tea, very remarkably enhanced, just Heavenly.
The combo of 300mg THH + LSD also makes the beauty & aesthetic enhancement way stronger than LSD alone, and the music sounds much better than LSD alone, it feels very much like when you combine mescaline with LSD, as THH is like the beta-carboline version of mescaline. Very beautiful combination.
Please note: all beginners only use around 150mg to 200mg THH which is what is found average in 1 cup of Ayahuasca tea, only advanced members of the UDV, Santo Daime, Shuar Indian and people like myself drink 2 cups of Ayahausca tea for the evening, which then contains around 300mg THH average.
P.S. Will be able to determine in future whether coffee filters or a cotton ball stuffed into a funnel will work in place of normally used vacuum pump with #101 filtration disc to filter out the remaining floating zinc dust (only around 10% left floating) after the spun solution sits for 1 hour as 90% of the zinc dust falls to very bottom, so solution above it can be decanted off. This would make it very cost efficient and easy for anyone to convert harmaline to THH without all the fancy equipment (buchner filtration flask and cup/filtration paper, vacuum pump).
1st paper: HPBCD DMT very bioavailable sublingually under tongue, combo with tetrahydroharmine, Ayahuasca
Harmaline to THH in 1.5 hour, way a chemist does it, see post #12: https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=96861
2nd paper: Oral Tetrahydroharmine + sublingual HPBCD DMT journeys, very similar to mescaline:
Oral tetrahydroharmine + sublingual HPBCD DMT journeys, very similar to mescaline - Pharmahuasca - Welcome to the DMT-Nexus
-----------------------------------------------------------
Update: Now we know why polysaccharides like those in aloe vera leaf and gel or the man-made polysaccharides like HPBCD increase the oral and sublingual absorption of DMT freebase by many factors:
Downwardsfromzero said a while back:
It just so turns out that you were absolutely right! Cyclodextrins such as HPBCD (hydroxy propyl beta cyclodextrin) are naturally occurring polysaccharides obtained through the enzymatic degradation of starch.
This explains how when HPBCD is complexed to freebase DMT, it is able to not only make it water soluble, but also make it absorb MANY FACTORS BETTER orally than normal DMT freebase or DMT salts.
This is why in my experience, the Ayahuasca tea made with HPBCD DMT is many factors stronger than normal DMT, easy to reach +5 Shulgin strength levels, just like the Hawaiian psychotria made Ayahuasca tea, which in all likely hood may also contain polysaccharides just like aloe vera leaf which explains why the Hawaiian psychotria leaf contained DMT easily reaches +5 Shulgin strength: all encompassing and super-strong. I've taken Hawaiian psychotria over 70 times in Ayahuasca made Caapi tea, and it's always been super potent, much more potent than freebase used DMT or salts in my experience. A world of difference, no comparison. The HPBCD DMT is the same, super potent just like the Hawaiian leaf.
Example from the scientific literature: HPBCD improves oral absorption profile for Ofloxacin, a second generation fluroquinolones by 54 to 89 percent.
Guess what else also contains polysaccharides: Aloe vera gel and leaf. Aloe vera gel caused a 3.7 fold increase in the bioavailability of vitamin C in comparison to control (vitamin C administered in water).
The polysaccharide fraction from dehydrated Aloe vera gel (datonmax 700) material could enhance the transport of many drugs across the intestinal rat tissue many factors over, and was statistically significant compared to control.
Aloe vera leaf and gel, due to the polysaccharides open tight junctions and consequently enhance paracellular transport of hydrophilic molecules.
Polysaccharides are the component of aloe vera gel and leaf that is the biologically active component responsible for the greatly increased modulation of drug pharmacokinetics and absorption -- this is concentrated in the polysaccharide components of the aloe vera gel and material.
The paper also shows that Aloe vera has also been shown to significantly enhance the sublingual and buccal permeability of drugs. HPBCD complexed freebase DMT does the same thing, it not only makes the DMT water soluble until it crosses the sublingual membrane, where it is released into the bloodstream as the potent freebase, where it reaches the brain intact in my experience, very potent indeed...
...but HPBCD, being a polysaccharide just like aloe vera gel or leaf, greatly enhances the penetration of the DMT thru the sublingual mucosa under the tongue due to it's potent disruption capabilities of the epithelium layer (only 100 to 200um thick), also discussed in the attached paper.
All of this is covered in the attached paper "Drug Bioavailability Enhancing Agents of Natural Origin (Bioenhancers) that Modulate Drug Membrane Permeation and Pre-Systemic Metabolism" by Bianca Peterson, Morné Weyers , Jan H. Steenekamp, Johan D. Steyn, Chrisna Gouws and Josias H. Hamman.
Last pic: The absorption of drugs through the sublingual mucosa route is 3 to 10 times greater than oral route according to Dr. Narang.
Pharmaceutics drug bioavailability enhancing agents (1).pdf 2.19MB 3 downloads
Attached Files
- Sublingual mucosa as a route for systemic drug delivery (31).pdf 240.7KB 0 downloads
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