LSD for ADHD
Greenlighter
- Joined
- Apr 28, 2017
- Messages
- 15
Hi,
I've been researching LSD and its positive effects for those with ADHD.
I would like to ask about opinions and any studies that show a correlation between LSD and a reduction in the severity of ADHD symptoms. I have researched some studies of epigenetic effects of LSD on dopamine receptors and transporters through 5-HT2A receptor downregulation. Perhaps more importantly to the reduction of the severity of ADD/ADHD symptoms is to glutamergic effects of 5-HT2A downregulation in the PFC. Many people think that it's dopamine that causes a reduction in ADHD severity; but, glutamatergic signalling is also as important.
I came across some anecdotal evidence that the main metabolite of LSD (2-oxo-3-hydroxy-LSD (O-H-LSD)) is actually a long-lasting metabolite of LSD with significantly more potent dopaminergic activity than the parent compound.
What I have done in regards to, what I believe, positive evidence and effects of LSD on ADHD (depression/anhedonia/alteration in default network activity from a resting state to a more proactive one) is to titrate my doses of LSD so as to not experience the hallucinogenic effects, while leading to persistent down-regulation of 5-HT2A receptors in the PFC as to facilitate glutamate activity, and thus leave the dopaminergic activity of LSD intact without psychedelia. My further hope, though not substantiated by scientific studies although I ask for your input on the matter, is that the metabolite of LSD would also contribute to pro-dopaminergic activity.
You might say that people already do this by microdosing; but, I'm taking this a step further. My idea is to persistently administer LSD (100ug daily) in doses that do not cause psychotropic effects while maintaining the positive effects for ADD/ADHD/depression/anxiety.
I'm just wondering if psychosis can be exacerbated due to constantly taking LSD in those doses, despite developing what some call "tolerance", whereas this "tolerance" would be sought after by me by not trying to trip.
My motivation for doing this is to rather take something that is cheap, natural, and by all means more healthy than amphetamines, derivatives, or methylphenidate, which act directly on dopmaine in a rather nasty fashion if you understand.
I've been researching LSD and its positive effects for those with ADHD.
I would like to ask about opinions and any studies that show a correlation between LSD and a reduction in the severity of ADHD symptoms. I have researched some studies of epigenetic effects of LSD on dopamine receptors and transporters through 5-HT2A receptor downregulation. Perhaps more importantly to the reduction of the severity of ADD/ADHD symptoms is to glutamergic effects of 5-HT2A downregulation in the PFC. Many people think that it's dopamine that causes a reduction in ADHD severity; but, glutamatergic signalling is also as important.
I came across some anecdotal evidence that the main metabolite of LSD (2-oxo-3-hydroxy-LSD (O-H-LSD)) is actually a long-lasting metabolite of LSD with significantly more potent dopaminergic activity than the parent compound.
What I have done in regards to, what I believe, positive evidence and effects of LSD on ADHD (depression/anhedonia/alteration in default network activity from a resting state to a more proactive one) is to titrate my doses of LSD so as to not experience the hallucinogenic effects, while leading to persistent down-regulation of 5-HT2A receptors in the PFC as to facilitate glutamate activity, and thus leave the dopaminergic activity of LSD intact without psychedelia. My further hope, though not substantiated by scientific studies although I ask for your input on the matter, is that the metabolite of LSD would also contribute to pro-dopaminergic activity.
You might say that people already do this by microdosing; but, I'm taking this a step further. My idea is to persistently administer LSD (100ug daily) in doses that do not cause psychotropic effects while maintaining the positive effects for ADD/ADHD/depression/anxiety.
I'm just wondering if psychosis can be exacerbated due to constantly taking LSD in those doses, despite developing what some call "tolerance", whereas this "tolerance" would be sought after by me by not trying to trip.
My motivation for doing this is to rather take something that is cheap, natural, and by all means more healthy than amphetamines, derivatives, or methylphenidate, which act directly on dopmaine in a rather nasty fashion if you understand.