The Big & Dandy Methoxetamine Thread - The 3rd Dose

[knock]

^it can really mess up your hearing for an hour or two on higher doses!

 

[lbeing789]

I was just thinking about the safety of the AMT/MXE combo... I've done it 4 times now and he been very good... but I've never actually done the MXE until the AMT settles in... I think maybe the reason why it isn't negative is mainly to due with the duration of AMT, the negative interactions must be staggered by the length of the effects and everytime I've done AMT it's taken 2 hours to come up, maybe 3 hours of stimulant like effects akin to MDMA then the rest of the trip is a kind of subtle trippy feeling not to dissimlar to a low dose mescaline/mushrooms combo, in fact it's very similar. I've only done MXE in that last phase/approaching the 5hr mark.. I've done MXE on MDAI as well and I didn't have any problems, I mean it didn't feel right, but it was enjoyable -I did feel things going in opposite directions and I felt quite a lot of physical tension and some moderate jaw clenching, this is interesting because MXE is probably a DRI but I wouldn't have expected jaw clenching from that combo.

 

[amanitadine]

Could you please provide a reference to tramadol's action as an inhibitor of serotonin reuptake, because it is generally not considered to have this effect. A link to Tramadol's action as a NMDA antagonist would be appreciated as well, because while this would not be unusual given its structure, this effect has not been noted in any medical literature I have read.

I'm thinking there is a difference in the understanding of acronyms here...

SNRI- selective norepinepherine reuptake inhibitor
SSR - selective serotonin reuptake inhibitor

Tramadol has a strong effect as an SNRI, much like venlafaxine. .and releases serotonin. NADA as an SSRI. The NMDA anatagonistic acticity is part of its action, and well known. I haven't searched for a link confirming such yet, but they are out there.

Cheers

 

[missimoo]

I just don't feel myself on dissociatives.

 

[missimoo]

I'm thinking there is a difference in the understanding of acronyms here...

SNRI- selective norepinepherine reuptake inhibitor
SSR - selective serotonin reuptake inhibitor

Tramadol has a strong effect as an SNRI, much like venlafaxine. .and releases serotonin. NADA as an SSRI. The NMDA anatagonistic acticity is part of its action, and well known. I haven't searched for a link confirming such yet, but they are out there.

Cheers

Venlafaxine doesn't play well with others. Its been linked to serotonin syndrome and is generally horrible on its own.

 

[foolsgold]

black sabbath and this stuff are walking hand in hand silly me N.I.B.

 

[Saucy]

I'm thinking there is a difference in the understanding of acronyms here...

SNRI- selective norepinepherine reuptake inhibitor
SSR - selective serotonin reuptake inhibitor

Tramadol has a strong effect as an SNRI, much like venlafaxine. .and releases serotonin. NADA as an SSRI. The NMDA anatagonistic acticity is part of its action, and well known. I haven't searched for a link confirming such yet, but they are out there.

Cheers

OK, I see where the mixup has occurred. Your thoughts on the acronyms are incorrect.

An SNRI is a Serotonin-Norepinephrine Reuptake Inhibitor
An SSR is the "Corvette Truck" produced by Chevrolet in the early 2000s
A Selective Serotonin Reuptake Inhibitor is an SSRI
A Selective Norepinephrine Reuptake Inhibitor is simoply called a NRI

The reason for the difference in acronym notation between a Selective Serotonin Reuptake Inhibitor and a Selective Norepinephrine Reuptake Inhibitor is as follows:

A Selective Norepinephrine Reuptake Inhibitor is selective in the sense that it is selective over other monoamine receptor sites (serotonin, dopamine, etc.)

Selective Serotonin Reuptake Inhibitor is selective in the sense that it is selective to specific subtypes of serotonin receptors, hence why its acronym gets the "S" in front of it, while inhibitors of Norepinephrine reuptake do not.

So your statement "Tramadol has a strong effect as an SNRI" is incorrect. Tramadol is a Serotonin Releasing Agent, and a NRI (norepinephrine reuptake inhibitor).

I still would like to see a link to Tramadol's action as a NMDA antagonist, please.

Regards,

-Saucy

 

[knock]

OK, I see where the mixup has occurred. Your thoughts on the acronyms are incorrect.

An SNRI is a Serotonin-Norepinephrine Reuptake Inhibitor
An SSR is the "Corvette Truck" produced by Chevrolet in the early 2000s
A Selective Serotonin Reuptake Inhibitor is an SSRI
A Selective Norepinephrine Reuptake Inhibitor is simoply called a NRI

The reason for the difference in acronym notation between a Selectove Serotonin Reuptake Inhibitor and a Selectove Norepinephrine Reuptake Inhibitor is as follows:

A Selectove Norepinephrine Reuptake Inhibitor is selective in the sense that it is selective over other monoamine receptor sites (serotonin, dopamine, etc.)

Selectove Serotonin Reuptake Inhibitor is selective in the sense that it is selective to specific subtypes of serotonin receptors, hence why its acronym gets the "S" in front of it, while inhibitors of Norepinephrine reuptake do not.

So your statement "Tramadol has a strong effect as an SNRI" is incorrect. Tramadol is a Serotonin Releasing Agent, and a NRI (norepinephrine reuptake inhibitor).

I still would like to see a link to Tramadol's action as a NMDA antagonist, please.

Regards,

-Saucy

Nice post Saucy (except for the "selectove" stuff, that hurts my eyes!). IMHO we need a damned glossary.

 

[foolsgold]

the strangest thing has happened i plug a good dose and nothing not a thing i just got wind ? gutted i was hopping to enter the next stage that way but nothing nevermind we live and learn

 

[Saucy]

Nice post Saucy (except for the "selectove" stuff, that hurts my eyes!). IMHO we need a damned glossary.

That's what I get for copying and pasting. Fixing original post now.

 

[ThanksLois]

Foolsgold, how much did you take? And did you remember to smoke a cigarette and drink a few strong cups of black coffee beforehand?

 

[foolsgold]

ok that just got weird

 

[icezizim]

Ive been doing small doses of unknown quantity for that last 2 months and only got as far as feeling a weird comforting buzz, doing small booster bumps.

so last night i got down to the last of the bag and decided to snort a line that was probably 3x as much as ive ever done at once to finish it off. for the first hour it was the same buzz as usual but stronger and for the first time a strange mania was noted. i came up with the plan to buy plane tickets to Cambodia and start traveling the world because my life needed to take a new direction. i was checking the price for plane tickets on cheapflights.com when all the sudden i got a intense sensation that i was spinning( to the point i would literally spin to catch up with it). i laid down in bed and didnt get up for 3 hours. i had this crazy spiritual experience of epiphany after epiphany while traveling inside another dimension that was folding and twisting me over and over that seemed to last a lifetime. when i finally realized i was in my room and i wasn't dead. i had another 30 minutes of pretty intense body sensations that still felt like i was being folded and twisted. i finally got up out of bed and couldn't walk worth shit. i couldn't go to sleep for another 2 hours and was afraid i was gonna wake up feeling like shit for work in the morning. when i took the dose i didn't expect or want such an intense psychedelic experience, i had gotten used to using the substance as an interesting sedative. well to my surprise after a measly 3 hours of sleep, i woke up feeling like a million fucking bucks! i dont even feel that good after 8 hours of sleeping. kinda feel like i wasted the gram i bought now that its gone and i just found out its potential.

does anyone else have a similar experience cause it totally took me by surprise.

 

[Albion]

Ive been doing small doses of unknown quantity for that last 2 months and only got as far as feeling a weird comforting buzz, doing small booster bumps.

so last night i got down to the last of the bag and decided to snort a line that was probably 3x as much as ive ever done at once to finish it off. for the first hour it was the same buzz as usual but stronger and for the first time a strange mania was noted. i came up with the plan to buy plane tickets to Cambodia and start traveling the world because my life needed to take a new direction. i was checking the price for plane tickets on cheapflights.com when all the sudden i got a intense sensation that i was spinning( to the point i would literally spin to catch up with it). i laid down in bed and didnt get up for 3 hours. i had this crazy spiritual experience of epiphany after epiphany while traveling inside another dimension that was folding and twisting me over and over that seemed to last a lifetime. when i finally realized i was in my room and i wasn't dead. i had another 30 minutes of pretty intense body sensations that still felt like i was being folded and twisted. i finally got up out of bed and couldn't walk worth shit. i couldn't go to sleep for another 2 hours and was afraid i was gonna wake up feeling like shit for work in the morning. when i took the dose i didn't expect or want such an intense psychedelic experience, i had gotten used to using the substance as an interesting sedative. well to my surprise after a measly 3 hours of sleep, i woke up feeling like a million fucking bucks! i dont even feel that good after 8 hours of sleeping. kinda feel like i wasted the gram i bought now that its gone and i just found out its potential.

does anyone else have a similar experience cause it totally took me by surprise.

Yeah that's the only sort of experience I aim to ever have on MXE %)

 

[suckerbunnie]

Yup, that's exactly how it is. Amazing substance. Spread the love, people

 

[foolsgold]

IM still gutted last nights plugging at attemped didnt work , really cant understand that i wont bother trying that way again . seems the best way with it is to simply stick it under your tounge and wait 30minutes for lift off . also its odd how im bored of it but im not if you know what i mean im all ready thinking how can i get a gram next week but theirs nothing new to learn or enjoy but i know il find something its amazingly beautiful but weirdly boring now METHOXETAMINE & ME FOREVER LOL

 

[Psyke]

Does anyone think frequent-ish use of this would produce similiar side-effects to frequent-ish side effects of dxm?

People who use dxm even every week or couple of weeks start going a bit dull...
vocabulary slips and something just isn't right.

Would anyone suppose that Mex could be similar in brain dulling side-effects?
I'm talking once a week or less here.

 

[Saucy]

Does anyone think frequent-ish use of this would produce similiar side-effects to frequent-ish side effects of dxm?

People who use dxm even every week or couple of weeks start going a bit dull...
vocabulary slips and something just isn't right.

Would anyone suppose that Mex could be similar in brain dulling side-effects?
I'm talking once a week or less here.

+1 I would like to hear opinions on this.

 

[greenberryhaze]

I don't know if this has been reported before, but gabapentin potentiates this stuff incredibly. I had taken 3600 mg throughout the day (my normal dose) and 22mg sublingual was as strong as my 70mg experience. No kidding.

 

[amanitadine]

Saucy -

yes, confusion cleared. I don't think anyone was ever arguing that tramadol was an SSRI, there was just (as I stated, on my part and others) some misunderstanding on the acronyms and what they entailed. . .Which was I assumed was the confusion on Shambles part I may be incorrect. So much for assuming. I think we were all clear about it being a serotonin releaser and not re-uptake inhibitor, and it having an effect as a NE reuptake inhibitor. But thanks for the acronym clarification, now we are all least on the same page. The concepts are solid throughout the english (and non english) speaking world, but the terms can vary.

As far as the NMDA antagonist properties of tramadol.....

I'm At work, and all I have at my immediate disposal are an older PDR (listing tramadols MOA including being a weak NMDA antagonist), an old package insert lisiting the same (from those samples that they used to dump by here weekly), and of course WIKI lists such, but I didn't check for a citation. But you are correct in that it's structure reeks of an NMDA antagonist, and I remember it being studied here amongst a few other opioids with NMDA antagonistic effects (methadone, levorphanol, etc) for both neuropathic pain and for the tolerance limiting factor of a combined opioid/NMDA antagonist. There was a lot of this work going here about a decade ago. I'm sure one could turn up some info with the help of a pubmed or even google search....

Cheers