I have been holding off posting this because I feel it may be slightly too unsafe for most people but I cannot sleep and I ended up here and I tried the various microwave/heat methods and I think I lost over half my target compound every time... expensive experiments. This is NOT recommended unless you are sure you know what you are getting yourself into. Please, it isn’t hard but it could be very dangerous, so do not attempt..
The following is a re-call from a dream I had not too long ago. I will try to remember what I did in this dream as best I can.
Goals: Obtain a product from the OP formulation with increased yield over the various described methods that is injectable (or snortable).
Materials (If you don’t have each and every one of these then only read this out of curiosity):
MICRON FILTER!!!
Freshly distilled and dehydrated Et2O, (DON’T use chemical dehydration methods ie. MgSo4, CaCl)
2x 15mL screw caps or similar
Some type of glass container for storing fractions
Ceiling fan to make a “fanerfuge”
Clean water
Something to dry stuff on
Syringes and the like
Procedure: (sorry not the best writer)
You can just (remove the color – optional as it will be removed by a micron filter later anyways) crush up some OP's as best as possible (more like shaved). Then wash 3 times in freshly distilled and dehydrated Et2O, volumes inexact, in something like a 15mL screw cap tube so you can shake it very well and “fanerfuge” it (explain later) using some type of glass rod to mash it up the first few times is helpful and a vortexer is nice but optional. Mix it up very very well each time, centrifuging it after shaking/mixing well by securely tying and taping a small string to 2 opposite sides of your ceiling fan blades and tying the tube and a balance tube to the "fanerfuge" (if I have to explain the principals behind this then don't even waste your time to try this, perform at your own risk, I’m not responsible for broken fans or walls or people!). Then let it spin down for like 2-10 minutes at top speed and draw off the Et2O however if particles remain suspended there is nothing you can do but wait and let gravity settle it out, sometimes a quick couple min is ok and sometimes if you shook it up really well it may take longer. Repeat this 3 times being most careful to remove all of the Et2O on the final rinse. Then let it dry out for a few minutes maybe blow into the tube a little bit then get a drying dish ready (pyrex, plate, etc...). Once it’s dry enough to remove it from the tube easily then you can tap it out and spread it out on the plate. Let this COMPLETELY dry. By the time the 3rd wash is done you should have a much nicer powdery substance... unless your Et2O wasn't dry enough then I don't know what would happen but I would bet it would increase solubility of oxycodone.HCl = badness. Make sure to chop up the powdery stuff really well when drying to get rid of ALL Et2O, it is possible to remove it all I believe but I have not had the chance to put it through GC so I cannot be sure, this alone is why I think this could be dangerous. . One time when I only did 2 washes with not enough Et2O in the final wash the powder left over had a slight gumminess to it when dry but adding a small amount of cutting agent (myo-Inositol) allowed me to completely get a nice powder for snorting but it was ok for injection being slightly still gummy (no cuts needed), anything less than you started is great and a tiny bit of gumminess in the powder will still make a nice solution…so just be sure to wash it enough or else it won’t be snortable without more work but it will still be injectable if you have a micron filter. Now that it is completely dry just take what is left and dissolve it in an appropriate amount of clean (preferably ddiH20) water, for this experiment 240mg 4.50mL was used. There will still be some things that don't dissolve. IMPORTANT: you should give the water some time to mix with the powder, heat is bad it dissolves more of the stuff we don't want, just a 15 minute RT soaking will do with intermittent pipetteing to keep it agitated. The solution is then drawn into a 5mL syringe and pushed through a 0,20micron wheel filter and collected in sterile tubes ready for injection (each 1.5mL sterile tube contains roughly 80mg but probably up to 10% less). This clear solution is very nice and is not very thick at all and IV's very easily. Do not attempt to inject this without micron filtering out all of the microscopic particles, most everyone knows the dangers but it is potentially worse with these pills.
Simple form:
1. Crush pills (5min)
2. Put in 15mL tube (2min)
3. Wash 3 times with Et2O (centrifuging) (8-30min)
4. Dry snort or go on to steps 5 & 6. (15min)
5. Dissolve in appropriate amt. of water and micron filter the solution (2min)
6. Slam (depends)
Total time: usually takes about 30-45 minutes
Premise of method:
My theory, I think someone here was disagreeing with me earlier (which as long as it’s healthy criticism is encouraged) so I am putting the disclaimer ** This is what I think is going on here not facts just speculation, I am open to criticism** I have no proof to back up my claims other than what is shown in the Results and Analysis section, what I have seen happen. So obviously I think I am correct but I definitely may not be. The discrepancy is the PEO which I don’t know if I have ever found out exactly what MW they are using but to me asking; would making the PEO and BHT soluble free the oxycodone.HCl from the matrix, and the response was discouraging enough for me to not try my plan for quite some time but I thought about it quite a lot and I decided that I shouldn’t let this stop me from doing what I think is correct.
“Afraid not. The PEO chosen by Purdue has a molecular weight in the millions. This is an extremely long molecule. maybe 15,000 times the size of size of an oxycodone molecule. Picture a piece of wrapping paper a block long and a marble. Picture thousands of each. Picture the wrapping paper crumpling around the marbles. That is what the mechanics of the delayed release process consist of. Until the PEO is hydrated, there is no possibility of the oxycodone escaping. When the PEO is dissolved, it mixes with your other digestive system contents, is degraded by the digestive process (probably specific digestive enzymes) and and the oxycodone has a chance to make its way out of the maze of degraded PEO particles by diffusion. Until the PEO molecules are degraded, much of the oxycodone will remain trapped.”
I get that completely conceptually and I agree in water (where the solvent has plenty of charged hydrogen that is involved with waters huge polarity and dipole to offer up for bonding and alter the electron cloud of the PEO which would strongly attract the oxycodone.HCl which is also soluble in water as a solvent) but I think (now from experience this is not happening here for whatever reason in the NPOS’s). PEO is big, I’m sure there are tons of inter-molecular forces between the oxycodone.HCl and the PEO when it is dissolved in water but oxycodone.HCl only has one significant bonding hydrogen and source of polarity (hydroxyl group) and possibly that nitrogen group in the bridge to cause a shift in PEO’s electron cloud and it has 3 significant acceptors (the free oxygen’s) but PEO doesn’t have many strong donors except at the ends and where it can be effected by other molecules, and itself. In a NPOS on the other hand most of the interaction would be occurring between the dipole moment of the Et2O causing a pull of electrons in PEO and thus there would be some very weak IMF’s between oxycodone.HCl and the PEO not to mention that the BHT and Et2O would do a great job at “displacing” the oxycodone.HCl from the PEO. This is why I think Et2O is a good choice for this. This is a complicated subject we are dealing with dipole moments, dielectric properties, shifting in huge molecules electron fields, small yet complex molecules and large molecules exhibiting many different forces. This polymer is dissolved into a NPOS and the bonding RADICALLY shifts from being solid, and stable to being dissolved within a new set of molecules that radically shifts the electron field of the molecule and in order for the PEO to dissolve, it MUST bond/interact with the Et2O. The molecule is now in constant movement it is no longer in equilibrium and the oxycodone HCl that was once trapped within this polymer mix is now insoluble in the solvent. I find it highly unlikely that with all of these shifts in structure and oxycodone.HCl becoming insoluble could PEO exert enough energy to keep/ pull oxycodone.HCl in solution while it is dissolved. There may be a good deal that get stuck in this highly organized matrix and that may be one of the reasons why oxycodone.HCl had shown a 2% extraction with diethyl ether along with Et2O’s dipole and H2O solubility. When the molecule is in what we would call its “solid” state bonds form and entrap all kinds of things, air, water, they do it purposefully with drugs too such as in this case, and dyes and plenty of other small molecules too. In this state the molecule is also heavily interacting with itself in this case mostly with itself but also oxycodone.HCl, BHT and whatever else which is what gives a good polymer its ability to hold its shape etc.. But in order for the PEO to be soluble in the solvent it MUST break many of the extraordinarily weak bonds that are holding the oxycodone.HCl tight to its web and “trade” for the bonds it makes with the solvent as it dissolves.
That aside…..::
oxycodone.HCl is basically insoluble in Et2O. The worst of the polymer(s) are soluble in the Et2O. Removing some of the polymers from the pills allows you to **in my opinion** remove the oxycodone.HCl from much of the “entrapment” of the BHT and PEO and get the pills to dissolve in water without gumming up at all which allows you to filter sterilize the solution and successfully inject the proper dosage. Once the “gummy” polymers have been removed then things go much smoother. (This is really just a basic “de-fatting” procedure, removal of fat-soluble components from a material from which fat-soluble substances are undesirable)
Results and Analysis:
The combined Et2O fractions were evaporated until precipitation begun, and then more Et2O was added to make it a fully dissolved solution. This solution was tested with Conc. Nitric Acid, Froede, Marquis, and Dragendorff Reagents. Nitric acid: very very faint change to yellowish. Froede: yellow green. Marquis: faint purple. Dragendorff: noticeable yet un-impressive positive reaction. These spot tests have detection limits on the microgram level so this doesn’t surprise me. I suspect you are losing 2% of the active compound each wash (see sighted paper earlier in thread). 0.25mL of the filter sterilized water soluble fraction was dried on a plate overnight. Then the powder was scraped into 5 small piles and tested with the same reagents as above. The 5th pile is for my mouth and nose to taste . I started out with what should have been 240mg oxy I dissolved into 4.5mL ddiH2O. Note: dripped 2 drops of each reagent onto each pile and observed the color changes. Nitric acid: quick and obvious change to yellowish with shine. Froede: yellow green. Marquis: purple. Dragendorff: Obvious positive reaction. Tasted very bitter and burned in the nose. The 0.25mL which should have been about 13mg of oxy was much more than that (water sol fillers) but it was easy to deal with so I don’t know what the exact yield was here but it seems to be pretty good and provides a final product that is suitable for injection and if done properly is suitable for intranasal administration. And in vivo animal testing provided evidence that injecting 1.5mL at a time of this preparation seemed equivalent to 80mg OC from experience.
Recovery of lost products (optional and probably pointless but fun, to my nerdy dreaming self at least):
After doing this multiple times the combined Et2O fractions were evaporated until precipitation begun. Then 1mL 3M HCl was added to the ether and shook well for 30 seconds. Upon standing for 2 hours (massive massive emulsion formed) 0.8mL ddiH20 was recovered using a 100mL sep funnel. This 0.8mL was then dried in the microwave like so, 30sec ---take out put under fan until cold, microwave 15 sec— take out put under fan until cold, microwave 15 sec— etc until close to all water has evaporated and then just let it evaporate on its own you do not want to ruin your opi’s. A small amount of seemingly clean powder emerges but when a razor blade is used to scrape up the powder it turns out to be pretty goopy. This goopy powder tested positive for oxycodone.HCl and the ether was no longer showing positive results for the dragendorff and froede reagent tests. The dried water fraction was re-dissolved in 1.0mL ddiH20 and filtered through a sterile 0.2um syringe filter into a sterile receptacle. The resulting solution was injected while in moderate withdrawal and withdrawal symptoms subsided shortly after so there had to be something in there.
That is ALL I can remember from my dreams. I started an opi recovery program so I am trying not to think about opi’s but writing this brings me back to the good old days, it was nice.
