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Bupe Suboxone/Buprenorphine FAQ & Megathread v3; 2010 - 2022

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^^ By your guys' standards Bluelight shouldn't even be a message board, they should convert it to a "Wikipedia for drugs" and ditch the discussion, because i doubt if much genuinely unique discussion has taken place here in a while.


In my opinion using the search engine successfully isn't nearly as easy as it's made out to be, and i think megathreads to a damn fine job at cutting back on the clutter. Who cares if questions get repeated in here anyway, doesn't hurt anyone.

I think you missed the tongue-in-cheek nature of my post. ;)
 
i just wanted to post about the post that was posted about all the re-posting. It seems repetitive:) This thread is still by far the most mature, informational, and for the most part non judgmental out there.:)
 
I always thought of these megathreads as more personal area, with experts hanging around in them helping to answer questions. It is much easier to get a direct, and personal response than searching through multiple anecdotes for a while. I figured it would be easiest to discuss in this thread, and ask questions when I needed, to people who had read my story in previous posts (of the megathread). If I didn't think it warranted a new thread, I found somewhere like this to discuss it. :)

If it impedes the thread so much, I'm sure people will agree to stop doing it. Maybe I just misunderstood the idea of this thread, and it is more suited somewhere else? Should we start a suboxone progression and question thread?
 
Well, i was just thinking about that and what triggered the thought was that i have been extensively reading old threads these past few days, dating back to 2006/07 and I realized that the amount of info (interesting to me) here is more than i thought and will probably take me a really long time to read it all. Wondering if the new mods are requested to go over all of the past threads AND posts just for educational purposes.
I also noted that a lot of the info and/or questions are repeated, and this was a few years ago, but the repetition is also happening in same threads and whole questions could be answered with old reply-posts. Then again, using the search engine isn't always easy or convenient for someone needing instant advice. I tried to use it myself a few times in looking up specific info and failed miserably.
Just an observation...I do like this thread specifically because it relates to where i am now. A few months back, i was still reading a lot about long term use of heroin.

Keep it up everyone, and DO read and educate yourselves, there is an endless amount of info on here and on Erowid.com and Opioids.com, i fell in love with reading all over again :)

Keep it up everyone

Wondering what will happen to this post since it's # 1002
 
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Whatsup yall. Peace. I just want yall to know suboxone fucking kicks ass!!!!! I just got on them yesterday, and immediately took away my heroin withdrawals :) <3.

TBH, sub probably saved my life.
 
^^ Welcome to Bluelight! :)

Suboxone can definitely be a life saver, just don't forget that it is itself very physically addictive. Don't forget that you aren't out of the water yet, because it's easy to do after being on suboxone for over a year. The withdrawal will always have to happen eventually. Of course a proper taper can avoid the worst of it and the improvement in quality of life is drastic enough to balance out any negative side of trading one drug for another.
 
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phrozen said:
What: Suboxone = buprenorphine/naloxone. Bupe is a partial agonist(mu) and antagonist(kappa). Bupe has higher mu affinity that most opiates, including some antagonists(naloxone, naltrexone). Its higher affinity allows you to shoot suboxone tablets. It also may cause precipitated withdrawals if you are dependant on other opiates. Also, its higher affinity blocks the affects of other opiates when taken in conjunction with bupe.

Dose: Depends on tolerance. 1-2mgs is a typical recreational dose for someone with no tolerance. If you're using bupe to taper off of another opiate, you should dose once you're experiencing wd's(typically 36-48 hrs. for most opiates). Start with 2-4mgs and dose at 2mg increments every 30-45minutes until a dose holds you. Most people take their full dose once a day.

Withdrawal: Typical physical and psychological symptoms associated with opiate withdrawal. Insomnia, chills, diarrhea, depression, anxiety, lacrimation, sweating, increased heart rate, etc. They are not as strong as a full agonist's symptoms, but may last longer. Physical symptoms last 1-2 weeks on average and psychological symptoms may last months.

As most opiates, it's recommended to taper down to the lowest dose possible before stopping. <1mg is ideal. The best way to dose at that level is to crush up a tablet and divide the powder into lower doses.

Ceiling: 24-32mgs

Bioavailability:
jasoncrest said:
Buprenorphine bioavailabilities:

intraduodenal: 9.7%

intrahepatoportal: 49%

intramuscular: 68%
"The observed mean intramuscular bioavailability was 68%"
"Studies of buprenorphine bioavailability have also examined the intramuscular (bioavailability, 50%–100%)"


intranasal: 50%
"Studies of buprenorphine bioavailability have also examined the [...] intranasal (bioavailability, 48%)
"The bioavailability of buprenorphine, HCl (BPP) in sheep after nasal administration of two formulations has been studied. 0.9 mg BPP in 150 microl was administered nasally and compared to 0.6 mg i.v. The test solutions were formulated with 30% polyethylene glycol 300 (PEG 300) and 5% dextrose, respectively. The bioavailability for PEG 300 was 70% (S.D.+/-27%, n=6), whereas the bioavailability for 5% dextrose was 89% (S.D.+/-23%, n=6)."
"Mean intranasal bioavailability was 48.2 +/- 8.35% (mean +/- s.e.m.) of the intravenous value"


intrarectal: 54%
"bioavailability of the drug was found to be: [... ]intrarectal (54%)..."
"Relative to the 100% bioavailability from the intraarterial route the mean bioavailabilities were [...] intrarectal, 54%..."

intravenous: 98%-100%

oral: 10%
"the oral bioavailability for buprenorphine is state to be 10%"
"due to extensive first-pass metabolism, buprenorphine has very poor oral bioavailability (10% of the intravenous route) if swallowed"


sublingual: ~30%
"Buprenorphine is well absorbed sublingually, with 60% to 70% of the bioavailability of intravenous doses"
"Study results indicate that bioavailability of sublingual buprenorphine is approximately 30%"
"Literature on bioavailability of sublingual buprenorphine presents variable numbers ranging from. 19–58% of the administered dose."

"Relative to the 100% bioavailability from the intraarterial route the mean bioavailabilities were [...] sublingual, 13%"

transdermal: 15%



Other Notes:


Images:
p05331b1.jpg

Subutex

p05331a6.jpg

Suboxone

Buprenorphine4%28a%29.preview.jpg

Generic Subutex Manufacturer: Roxane

bupr5378.jpg
bupr5379.jpg

Generic 2mg Manufacturer: Teva | Generic 8mg Manufacturer: Teva

Film_wide.jpg

2wrkytz.jpg

Suboxone Film Strips

bupe_tablets.jpg

Temgesic, 0.2mg

16buprenex.jpg

Buprenex Ampules

Locate a doctor that prescribes Suboxone.

Suboxone Assistance Program - Free Suboxone for Low Income Patients
 
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Frequently Asked Questions

Q: How long after my last bupe dose can I take an opiate and feel its effects?
A: It depends on what dose of bupe you were taking and how long. The short answer is 36-48 hours, though it may certainly be less, or more than that. Caution should be used when dosing, as you will still have a tolerance but it will not be as high as it was when you first got on bupe.

Q: I'm thinking about switching from methadone to bupe. At what methadone dose should I be when I switch?
A: Most places recommend being at 30-40mgs of methadone when switching. That may be hard to achieve since that level is lower than the recommended therapeutic maintenance level. Also, you'd have to wait at the very least 36-48 hours before your last methadone dose to switch in order to avoid precipitated withdrawal.

Q: Is bupe good for depression/anxiety?
A: Yes, it may help with depression and anxiety. It is not currently prescribed for either and its effectiveness has not been studied for long term use for either. You may be able to get it prescribed off label for depression/anxiety, but its not likely to happen. Here is an article on PubMed about a study on bupe being used to treat depression.

Q: Is bupe recreational?
A: Yes. Although it is rarely the preferred opiate for people who have experience with full agonists, a few people do prefer it to full agonists (i.e. morphine).

Q: Can you overdose on buprenorphine?
A: Yes you can, but typically not by itself. Buprenorphine causes respiratory depression which may lead to death, but typically wouldn't do so in a healthy individual, unless you combined other CNS depressants with buprenorphine, like benzodiazepines, alcohol, barbiturates, and other downers. The person most likely to OD on bupe has a low(if any) tolerance to opiates and may have taken another depressant. A buprenorphine overdose may not be reversed by naloxone(or naltrexone for that matter) due to bupe's higher affinity. Diprenorphine may reverse the overdose, but it is not regularly stocked by emergency personnel or hospitals. If a proper antagonist isn't available, the person suffering an overdose may be maintained with assisted respiration.

Q: Can I still get high on other opiates if I'm on bupe?
A: This depends on what dose of bupe you're on. You will most likely be able to shoot through a low dose of bupe (1-2mgs). Though some might be able to expect the full effects of the opiate you're shooting through with, it is often only partially felt for many people. Even at higher doses, if you take enough of the opiate you may feel it. This is not recommended, as you may overdose before reaching the desired recreational effects. It is better to wait until bupe is no longer effecting you, or to stick the course with bupe treatment.

Q: How come you can IV Suboxone? Isn't naloxone going to put you into withdrawal?
A: No, naloxone will not put you into withdrawal. If you are using heroin or a full agonist, and then use Suboxone, you will go into precipitated withdrawal if you don't wait for regular withdrawal first. If you are otherwise already on buprenorphine, IVing Suboxone will not put you into withdrawal. This is because buprenorphine has greater receptor affinity than naloxone does
http://www.bluelight.ru/vb/showthread.php?t=541906
. There is no functional reason why naloxone is in Suboxone, and for all intensive purposes, Suboxone and Subutex are the same thing - both can be used with any route of administration.

Q: Is Suboxone safe to IV?
A: In essence, you should not shoot Suboxone. Unless you have enough patience and money to afford and use micron filters, Suboxone or Subutex, like any other pill, has risks when IVing. Missing a shot of Suboxone or Subutex may be more detrimental to your health, when compared to shooting out of a sterile ampule, or pure drugs in sterile water. Please read up on injection complications regarding pill based drugs, like Subutex, in the Case Studies thread. It is better, if you are truly intending on IVing buprenorphine (outside of the ampule version Buprenex), to read up on my Micron Filtering Mega Thread and FAQ and then purchase the necessary supplies to help enable a safer shooting experience for yourself.

Q: How good is bupe as an analgesic? What are the pain-killing properties like in comparison to other opiates?
A: This may vary from individual to individual, but what I can say for the average person, you will probably find that it is about half as good feasibly speaking as an analgesic (pain-killing) medication, compared to an equipotent dose of heroin, morphine, oxycodone, and so on. I have talked to several people who are pain patients, and they have a general consensus that while full agonist opiates are much better in the pain killing department, buprenorphine does help considerably when taking off the edge in mild to somewhat moderate pain cases. For people with moderate to heavy or severe pain issues, buprenorphine can do but only so much.

Q: If I am a pain patient, can I utilize buprenorphine?
A: Yes, it is possible. It will be most likely you will combine a compatible drug, like tramadol with it. However if you are going to combine full agonist opiates like morphine, hydrocodone, oxycodone, heroin, and so on, you are probably going to want to take a dose of buprenorphine first, and then once the effects are going, you can use other full agonist opiates on top of buprenorphine. However, you can't take another dose of buprenorphine until the full agonists have left your system. This is why if you're already dependent on full agonist opiates, it's better not to use buprenorphine as well (as you may go into precipitated withdrawal). If you have mild to moderate pain at best, and it flares up sometimes but doesn't at others, then you may be able to combine both buprenorphine and a full agonist on the days you need to, and then on the days you don't, you can stick to strictly buprenorphine.
 
Suboxone Mega Thread Directory - Other links about buprenorphine in Other Drugs

Alcohol and Suboxone - Alcoholic Solutions for Higher BA With Sublingual Use**
Buprenex - should I IM or IV?
Buprenorphine and Antihistamine IV FAQ
Buprenorphine as a recreational drug?
Buprenorphine dosages commonly prescribed are unnecessarily high
Buprenorphine for depression?
Buprenorphine patches
Buprenorphine withdrawals?
Ketoconazole Potenation of Suboxone
Mephedrone and Buprenorphine
Micron Filtering Mega Thread and FAQ - How to Micron Filter Suboxone
Nasal Administration of Suboxone - Issues
Rectal (Plugging) Buprenorphine
Suboxone in place of Naloxone in the event of an opiate overdose*
Suboxone sublingual film official thread
Subutex has gone generic
Tramadol and Suboxone

Discussion in the Suboxone mega thread goes along quite quickly, so we have a few other threads to promote intermediate/advanced discussion of buprenorphine and its formulations. These threads are meant to divert some of the more advanced discussion that otherwise becomes buried in the mega thread.

If there's another link you think which would go well in this list of related buprenorphine threads, please let me know. We're trying to reserve extra threads on buprenorphine for more intermediary/advanced discussion mostly to reserve the mega thread for a place for questions that can be answered quickly, and the other threads for a place for questions which will otherwise not get the same discussion going on in the mega thread, due to its quick pace.

If you have an idea for a new thread on buprenorphine, it's probably best to figure out by talking to a moderator first to see if it's thread worthy or should be discussed in the mega thread.

*Not Advised. Opiate antagonists are the only safe thing to do in case of an opiate overdose. Please do not give people Suboxone if they have overdosed.
**also known as "6/7's method" or "SixPartSeven's method"
 
Nice.


I've only got like .8mgs of sub left so I'm hoping my kratom arrives today, if not tomorrow. Which it should but there hasn't been any update on the usps tracker for 2 days and It should only take 2 days to get here anyway, so i hope nothing happened to it. Ordered 10 ounces this time rather than 5 so it should last long enough this time to get me through the entirety of withdrawal. Just have to make sure it doesn't run out while driving out to San Francisco that would suck, driving cross country in withdrawal sounds like the worst time/place to be withdrawing.

I just hope i don't fuck it up again. I know if i want to i can find heroin in Frisco, but at least it wouldn't be quite as easy as it was when i was back in Jersey. I swear there is so much heroin in north jersey now it's indescribable.
 
New thread time :D

How's everyones bupe treatment going?

EDIT: caseface beat me to the first post lol.
 
Nice.


I've only got like .8mgs of sub left so I'm hoping my kratom arrives today, if not tomorrow. Which it should but there hasn't been any update on the usps tracker for 2 days and It should only take 2 days to get here anyway, so i hope nothing happened to it. Ordered 10 ounces this time rather than 5 so it should last long enough this time to get me through the entirety of withdrawal. Just have to make sure it doesn't run out while driving out to San Francisco that would suck, driving cross country in withdrawal sounds like the worst time/place to be withdrawing.

I just hope i don't fuck it up again. I know if i want to i can find heroin in Frisco, but at least it wouldn't be quite as easy as it was when i was back in Jersey. I swear there is so much heroin in north jersey now it's indescribable.

Good luck, man. That sounds like a really tricky predicament. If you have the means, maybe look into finding a sub doctor in Frisco. Even if you don't plan on doing so, it can help psychologically to have a backup plan in mind (a mental safety net, as it were).

When I started Suboxone roughly a month ago, it was pretty much a spur-of-the moment decision. The pain clinic I'd been getting my oxy scrips from had to change doctors 'cause the main doc got in some trouble (over-prescribing, I think), and their scheduling got all screwed up, leaving me to suffer. I waited eight hours and still wasn't seen. But I saw the writing on the wall, and I quickly called and made an appointment with a Sub doctor (one I had previously seen but flaked out after five days). When I finally saw the pain doctor the next day, he ended up cutting my oxy supply down by a third. Had I not made the appointment to see the Suboxone doctor, I would have been massively freaking out; not only was my scrip smaller, but it ended up taking me a week to fill, meaning I would have run out and gone into withdrawals in the middle of the workweek.

So yeah, I guess my point is always have a backup plan, whatever it may be.

How's everyones bupe treatment going?

Last week, I was down to about .5 mg of Suboxone (sublingually) a day. But because my Crohn's pain started getting to me, I've been taking around 1.5 to 2 mg (insufflated 'cause I just got pills). The good news is that I no longer have to go in to the doctor's office every week. I go back in a month, and we'll decide where I should go from there. The question is whether I want to taper off completely or stay on for pain management. I'm leaning toward the latter because it has definitely helped, and I know I'll be miserable without it and eventually end up taking something, likely Percocet. Either way, I'm steering clear of the 30mg roxicodones. That's what got me into this mess in the first place.
 
Youhou, new thread, let's keep it interesting and informing.

I'v been reading a lot lately, studies about Naloxone's headaches, and about the availability of the antagonist in the Suboxone and earlier in Talwin Nx, and that it's all about patenting and the big "scary" pharma crazy ass revenues. I'm also about to finish "Big Bucks, Big Pharma" good documentary, and since i'm a serious documentary guy (can watch 6-8 hours over a few j's) so a doc about drugs...of course! Bring it on!
I knew some of the info already but it's a nice eye-opener about what's really going on around us.
Anyways, the pharmacy called me again (weird) but i didn't pick up and found a miss call from them, the 2nd in 4 days. The 1st time i called them back, i made sure they got my Subutex instead of Suboxone, and said i'll pass by within the next few days. Are they calling me again today because they closed earlier than normal as it's a national holiday?? Do they care about me so much!? Don't think so, i even mentioned last time to the woman on the phone that i will be driving all the way from Canada to come pick it up, so no more fuck ups please and enough is enough.
I also still can't believe my doc who charged me 50$ to mail my Subutex prx to the pharma!!
If it was Suboxone, it was ok, but Subutex "no, it's sketchy, and i'm trying to help you here"
REALLY? 50$ for the mailing stamp!?! Or as he said a few times: "gotta leave something for the reception" YES! THE RECEPTION INDEED! I'm checking in at the Park Hyatt, that evil witch doc!
Anyways, keep on learning everyone, you'll be amazed by how much is there to benefit and add to our knowledge.


Very Berry good thread:

http://www.bluelight.ru/vb/showthread.php?t=410997
 
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Jacob my pharmacist dude was talking to me today. He said, to whet ones whistle before dissolving Subutex under the tongue, because it helps stimulate saliva glands.

That said, we moved onto talking about absorbsion rates, and he said when a drug is swallowed, it goes thru the liver and some 80% of it is rendered ineffective by the liver. This is why people take this drug subligually. He also said, that I.V.ing is another means of taking this drug effectively | its the same as subligually in one sense that both ways by-pass the liver.

Interesting stuff...no?
 
Jacob my pharmacist dude was talking to me today. He said, to whet ones whistle before dissolving Subutex under the tongue, because it helps stimulate saliva glands.

That said, we moved onto talking about absorbsion rates, and he said when a drug is swallowed, it goes thru the liver and some 80% of it is rendered ineffective by the liver. This is why people take this drug subligually. He also said, that I.V.ing is another means of taking this drug effectively | its the same as subligually in one sense that both ways by-pass the liver.

Interesting stuff...no?


I'm not sure if i know what you mean by "whet ones whistle"

1st time i took the Subs a few years ago, i was told to drink water and make my mouth wet 1st, then put it under tongue AND not to drink water for 5/10 mns. afterward.
Of course at the time, i didn't know shit about absorption or metabolism, all i had in mind what that wonder drug that will help me with the wd's.
I was in the UK at the time, and by the 2nd day, i had a nice big meal and smoked a lot of weed, and was constantly waiting to throw it all up, but it never happened and i slept well. Woke the 3rd day with amazement as i haven't eaten this much and this well for 7/8 years! I started googling Subutex and i remember well, many sites were talking about not mixing it with benzos (no xanax) wonder why this info was all over the net at the time.
My 1st day, on 6 mg, i did 3 gm of blow, and all i got was a headache that made me take another 2mg, totaling 8 and slept ok with a light but annoying headache. Plus, the blow wasn't the blow i used to get there back in the days, but apparently the quality has gone down dramatically since the late 90's. The dealer even explained that the blow comes from S.America to the UK and the quantity is tripled by the mafia by adding paracetamol and speed!! Hated it, eventhough i'm not a coke head at all.

Sorry for rambling, i'm probably excited as i just called the pharma and made sure they got my Subutex (like the 3rd time!) I just need to drive to there and pick it up, and i'll be finally free from this Suboxone headache i'v been daily tolerating for a month :p
 
I have a question for the bupe users...
Last night round midnight I started on SUBOXONE
A nd was able to sleep a little then was waking up this morn unable to really sleep so I took a small bit more
Totaling between 4 and 6 mgs... then today stupidly went and got a bag and banged that... I didn't really feel a nything from the shot didn't make me feel better or anything..

My question is...
When will it be safe for me to take more SUBOXONE?
Since the h didn't really do anything to me does that mean that the subs didn't let it affect me at all?
I'm not feeling much withdrawl symptoms rite now but a little bit of chills

I'm not even sure if it because I'm under opiated or because I'm still getting used to switching from switching from h to the subs still :/

Any advise is greatly appreciated. Thank you.
 
I have a question for the bupe users...
Last night round midnight I started on SUBOXONE
A nd was able to sleep a little then was waking up this morn unable to really sleep so I took a small bit more
Totaling between 4 and 6 mgs... then today stupidly went and got a bag and banged that... I didn't really feel a nything from the shot didn't make me feel better or anything..

My question is...
When will it be safe for me to take more SUBOXONE?
Since the h didn't really do anything to me does that mean that the subs didn't let it affect me at all?
I'm not feeling much withdrawl symptoms rite now but a little bit of chills

I'm not even sure if it because I'm under opiated or because I'm still getting used to switching from switching from h to the subs still :/

Any advise is greatly appreciated. Thank you.
 
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