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Miscellaneous The Big & Dandy Cross Tolerance Thread

^^ POssibly because the more active optical isomer of MDA is the R isomer, but with MDMA, it's the S isomer.

As to the phenethylamines, yes they do seem cross tolerant. From experience there is for 2C-C/2C-I; 2C-D/2C-E anf 2C-T-21/2C-T-2.

My concern was whether there was any cross tolerance between amphetamines and the 2C-X compounds (not in terms of psychedelic effect, but of the stimulant edge of drugs like 2C-I).

In the big scheme of things, LSD (ergoline), psilocybin (tryptamine) and mescaline (phenethylamine) are known to be cross tolerant. The only one that isn't is DMT, which doesn't even induce its own tolerance (incidentally, one of the criteria for being a neurotransmitter)
 
My concern was whether there was any cross tolerance between amphetamines and the 2C-X compounds (not in terms of psychedelic effect, but of the stimulant edge of drugs like 2C-I).
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Tolerance to the dopaminergic effects of drugs seems to take longer to develop in general - is this correct?
 
Cross tolerance question

Hello all.

I just have a quick question about psychedelic tolerance/cross tolerance. I did search, but it's kind of a specific question which would need the input of experienced psychedelic users.

In a few days, I am planning to take a small dose of dried mushrooms (1/2g - 1g) followed a couple of hours later by a large dose (30mg) of 2cb (don't bother asking me why I would do something so strange). I am aware that there is some cross tolerance between the two substances, I was just wondering if it would be worthwhile.

I know from experience that after initial dosing of a psychedelic further dosing generally only leads to a prolonged high rather than a more intense high. However, I was wondering if this effect would still be present when the initial dose is so small. I wouldn't want to waste the 2cb.

Even with all the pharmaceutical knowledge in the world this is one of those tricky situations where people's personal experiences give a far better indication of the likely outcome. So that's why I posted this thread.

Sorry if I stepped on any toes or missed anything during my search.

Thanks for reading :)
 
Don't forget about Google MB. I found hundreds of results. I'm not trying to say UTFSE, but the web is a resource as well. There is cross tolerance between most 5HT2a agonists, but to what degree it changes the subjective experience I'm not sure. I doubt there would be as strong a cross-tolerance between 2C-B and LSD as there is between LSD and psilocin. That last part is not fact just me, but my reasoning is thus: while they primarily act on the same receptors the ratio of different of activity in different modules is different. As well as the fact that there's probably a lot going on we don't know about yet as well as somethings we think we know that are wrong. But yes, they are cross-tolerant.

PAX,
PL
 
Yeah, I did have a look, but all I could find was a mention of cross tolerance, whereas I'm looking for more specific details about the tolerance developed after small doses of psychedelics. I thought asking for subjective experiences was the best way to go about it.

But thanks for replying so if it does get locked I don't look like quite such a noob ;)
 
I have found tolerance to develop to some extent between doses of any psychedelics. However, tryptamines like the alkaloids in mushrooms produce much less cross-tolerance to phenethylamines like 2C-B than two phenethylamines or two tryptamines would.

Additionally, it seems to me that two different substances, even ones chemically close to each other, will never produce as much tolerance as taking the same chemical twice in a short period will. Also, it seems that psychedelics in the same "family" (like the 2C-Xs, DOXs, 4-substituted tryptamines, etc) will produce the greatest amount of tolerance for others in that family.

Examples:

Taking 2C-B would produce lots of tolerance to 2C-E, a good amount but less tolerance to DOC, and not a lot of tolerance to mushrooms or 4-AcO-MiPT. In my experience.

You should be able to take the combination you mentioned. The 30mg of 2C-B will not work as strongly as it would had you not had any psychedelics recently, but it will work pretty well. In fact, the result of combining the two will probably be synergistic and stronger than either alone with no tolerance. Probably the best way to get the most effects out of both would be to take them at the same time, so that you have no tolerance when either is taking effect.
 
I've used psychedelics for unhealthily long periods and mostly what I've noticed is that the spark or magic, the mantras of esctasy and wonder are not as pronounced or absent entirely. I've eaten mushrooms and acid and didn't notice much difference but always employed the double-dose. I found on low doses of DOC that I didn't incur much tolerance just an insane fiending for the drug. I couldn't fall asleep and I'd think, "Eat some DOC," with the full knowledge that it doesn't lead to sleep. Oh and you're taking these drugs concurrently which I seemed to miss until I just re-read the original post. I'd say enjoy I've not experience said combo, but I doubt there would be much a change in dosage with 2c-b. And really, if you're planning on eating a whopping dose after you're done with the mushrooms you might not feel like it. Or you may well. Don't eat it out of some sense of, "I need to do this," or "Now I'm a drug warrior. Hooyah!" People get into trouble with that type of attitude. Not saying that's you, just something I've seen.
 
Pimp Lazy said:
Don't eat it out of some sense of, "I need to do this," or "Now I'm a drug warrior. Hooyah!" People get into trouble with that type of attitude. Not saying that's you, just something I've seen.
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Haha yeah, I know what you mean...And the drug warrior attitude usually works okay with pills, speed, nitrous and all those, but then when people think they'll take on psychedelics they wind up in a bad place.

Honestly, the reason I wanted to take a low dose of mushrooms is because I don't take drugs very often, and I want to test the strength of these mushrooms I'm getting. But seeing as I don't have too many big nights, I also want to cram a proper 2cb trip in. And last time I took 15mg it was barely noticeable. Hopefully that makes sense to someone, its a bit of a wierd situation ;)

But thanks for the concern anyway, I know that it's one of those situations where if you were aware of your ridiculous attitude you probably wouldn't have it in the first place. But you won't find me using the acronyms 'LOL' or 'swim', or posting in threads just so I can talk about how fucked I was, if that gives you any reassurance %)
 
Mussoman_Beast said:
Honestly, the reason I wanted to take a low dose of mushrooms is because I don't take drugs very often, and I want to test the strength of these mushrooms I'm getting. But seeing as I don't have too many big nights, I also want to cram a proper 2cb trip in. And last time I took 15mg it was barely noticeable. Hopefully that makes sense to someone, its a bit of a wierd situation ;) %)
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I don't think that's weird at all. I wish I had both available to me. Mushrooms in the same batch can vary in potency by a factor of 10. I read that tidbit last evening. I guess mushrooms are so balancing afterwards that the thought of additional drugs doesn't strike me as appealing. However, the combo most certainly does. Insightful, silly, giggly energized color orgasm. Or so I imagine. Best of luck.

Peace,
PL

EDIT: Oh dude.. I guess I'm pretty frank. You sound like you're with it, like you know the score. Just wanted to put that though out there for consideration because sometimes, I'm guilty, the desire for a higher level of insanity, as well as fried out thinking, leads to unpleasant sitcheeaashuns. But I suppose that's really not an issue, because you've got time. Nothing like eating acid and partying all night and then eating some more as the sun comes up and going to work :-(.
 
Cross Tolerance

There is a good amount of cross tolerance between most classical 5-HT2A agonist psychedelics. For example if someone takes L their 2cb will likely be quite useless the next day...
So the question is which psychedelics seem to exhibit less pronounced tolerance with other psychedelics. There are certainly some well known exceptions... DMT can be puffed all night, MDA and MDMA seem to exhibit no cross tolerance.
 
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I have 36+ free hours free this weekend to devote to tripping for the first time in quite a while. I'm looking to combine a few substances/stagger them over this period. The problem is that I have pretty much only Tryptamines. I plan to provide a base of a solid dose of AMT. I also have shrooms, DMT, DPT, 5-Meo-DMT and 4-Aco-DMT. Will I experience significant cross tolerance between the AMT and any of the other tryptamines? Any great combinations?
 
I would guess the AMT would be the most dissimilar. It's effects are pretty different from most tryptamines. I too would like to hear some great combos... I've got 3 days so I could dose twice with a day off in between, possibly mescaline+2cb then DOC + L two days later.
 
4-aco-dmt and Mescaline cross tolerance?

Going camping this weekend and planning on having some fun. Was thinking of taking the 4-aco-dmt Friday night and then spend Saturday on the Mesc. But... I do not want to mess up my Mescaline trip by using 4-aco-dmt the night before. Anyone know if it will?

Thanks

FryHead
 
Cross Tolerance is determind by a drugs affinity for certain receptors sites and how long the drug shows activity at said receptors. Drugs that are 5-ht2 agonists(Ergolines/tryptamins/phenethylamines, etc.) for example, all show activity at similar receptor sites and may have some cross tolerence.
 
Xorkoth said:
I have found tolerance to develop to some extent between doses of any psychedelics. However, tryptamines like the alkaloids in mushrooms produce much less cross-tolerance to phenethylamines like 2C-B than two phenethylamines or two tryptamines would.

.
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that pretty much sums it up
 
djfriendly said:
Right, thanks for these answers.

What I was wondering was if anyone had noticed anything unexpected. For example, one would expect MDMA and MDA to be cross-tolerant. I've never put this to the test, but at least according to Shulgin they are not. Well, OTOH, I've always wondered if that one documented experiment wasn't just a fluke.
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Surprisingly, they are not cross-tolerant. When I tried IV MDA (~100mg), about 6 hours later (4-5 hours after effects had cessated) ate a roll (200mg MDMA); and I was still rolling hard. Nearly no cross-tolerance, I expected to need the whole 200mg to roll at all - boy was I wrong. 8( my eyes were shaking violently and it was hard to focus on anything at all.

That was after the most intense experience of my life - that being the half hour duration of IV MDA. I couldn't begin to explain how amazing the experience was.
 
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Was planning on taking 2C-B one night at a festival, and then MDMA the third night.

For someone who doesnt take MDMA that much, and will have only taken 2C-B 4 times by the time of the festi, how will this cross-tolerance be?

To the point where doing one of those PEA's one night will make the other on the third night feel nonexistant?
 
I have a five day music festival coming up and I am looking for some advice. I will be taking a good amount of substances while I am there, I do not trip often normally so I am unclear about the cross tolerance of some of the substances. My pending 'schedule' thus far is as follows:

Thursday: 2c-b
Friday: LSD
Saturday: MDMA
Sunday- 4aco-dmt

Do you think that I will run into a big cross-tolerance with this schedule? Should I switch a few things around?

Thanks in advance for your help guys :)
I know that I will not be feeling the greatest after all that, but I normally only trip once or twice a month and have never done this many psychs in such a short amount of time before so it will definitely be an experience
 
Had some weak LSD this afternoon-- OK to shroom tonight?

Alright, so like 3 and a half hours ago I took a hit of acid, just a sweet tart that had been dropped with liquid. I know it's legit acid from what others who took this batch experienced. But aside from a very very slight change in perception I'm not really tripping at all. It's like I started to come up an hour after I took it, felt that acid body buzz and whatnot... but that all dissipated just as quickly and by now I feel damn near sober.

Thing is, I got the hit last night, and it was just in a regular plastic bag for several hours afterward in a car... so I'm thinking the LSD degraded, hence the underwhelming effects. I've experienced this before with acid on sweet tarts, no matter if I kept them in a cool and dark place, even for only a couple days (or 12 hours, in this case).

Anyway, seeing as this "dose" was so low would it even matter if I took about 2g shrooms tonight? They're supposed to be unusually potent as well (my buddy took 1 1/2g of the same and tripped hard - said it felt closer to an eighth)... so I wouldn't think it'd make a difference, but I just want to make sure. I know there's a cross-tolerance between LSD and psilocybin but dunno if it would matter with such a low dose of acid.
 
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