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Delta 8 THC Megathread

w01fg4ng said:
Another natural substance, terpenes (cannabis derived or not), I suspect to be more toxic than olivetol. Terpenes themselves have already been shown to be toxic at certain temperatures so I suspect the same with olivetol.

Terpenes I believe can be healthy and beneficial but the window of use is very small and breaks way to carcinogens when heated to higher temperatures. This in itself is reason enough for my desire to stop dabbing and make a move to tincture only. The olivetol semi-scare is just another small push in a similar direction for me.
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yeah man, like limonene... I believe is technically food safe but I also used it as a nonpolar acidic solvent to extract DMT. Pretty hardcore shit...

lots of pretty hardcore terpenes out there
 
do not understand how they can have Sativa or Indica from Hemp ........ Can Not get any answers on that--
 
MaBudd said:
do not understand how they can have Sativa or Indica from Hemp ........ Can Not get any answers on that--
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Marketing.

They take the terpenes from various strains and add them back into d8

It's just the same d8 but will taste like indica or sativa, no difference in effects.
 
Negentropic said:
Marketing.

They take the terpenes from various strains and add them back into d8

It's just the same d8 but will taste like indica or sativa, no difference in effects.
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Fwiw I’ve seen some delta8 being sold with sizable quantities of CBD and CBG added.

While I don’t subscribe to the indica/sativa dichotomy sufficient concentrations of those may impact the effects, but admittedly not greatly if at all
 
so - here is the best write up on the pharmacology of minor hemp noids I've ever seen - https://www.frontiersin.org/article...dJ7sQf2-06PNjmk9Mq9Cld97aRznwzkP4hwllpQL9sy2k

TRPv differences are facilitating the release of different neurotransmitters downstream, including GABA and endogenous opioids -- IMO this is why we see such differences in the different noids "more pain relief, more anxiety relieving" etc.

also, I just went through a benzo withdrawal. If I spend even a couple of days dabbing d8 I begin to develop GABA withdrawal symptoms, complete with shakiness, tachycardia and nervousness. It goes away pretty easily, but it's a thing.

**edit** another paper about mu/trp interaction : https://www.pnas.org/content/pnas/114/51/13561.full.pdf

also interesting to note -- FULL ON synthetic CB1 agonists are causing death by GABA blockade. I was helping the research side of some people trying to get together a good protocol for emergency admissions re synth noids.

ativan + CBD ( I am urging them to add CBG, but it has no FDA approval :( only known tolerated CB1 antagonist) is what was finally decided on.. they are having seizures/multi-organ failure/hyperthermia from complete glutamate overload and GABA shutdown. :( not a great way to go.

CBG is also a triple reuptake inhibitor at GABA/DOP/NOR. Fascinating stuff in the noid world. I also feel like it's one of the best mental health meds I've ever taken.
 
cdin said:
also, I just went through a benzo withdrawal. If I spend even a couple of days dabbing d8 I begin to develop GABA withdrawal symptoms, complete with shakiness, tachycardia and nervousness. It goes away pretty easily, but it's a thing.
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yeah, THC has an antagonistic function at GABA especially at higher doses

went thru a benzo withdrawal few months ago myself and the first thing I did was put down the d8 for that reason

this is part of the reason it can produce anxiety in a lot of people
 
Negentropic said:
yeah, THC has an antagonistic function at GABA especially at higher doses

went thru a benzo withdrawal few months ago myself and the first thing I did was put down the d8 for that reason

this is part of the reason it can produce anxiety in a lot of people
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That’s the interesting thing/thing about trp pathways and noids —- d8 was fine for me in benzo wd, d9 intolerable. And I get withdrawal from d8. Also - my sleep depth etc totally changes with d8 in a way that only gaba agonists produce in me. Took some last night and my watch is like “what did you do??! Your sleep was amazing!” — now I use it about twice a month just to catch up on sleep.
 
cdin said:
That’s the interesting thing/thing about trp pathways and noids —- d8 was fine for me in benzo wd, d9 intolerable. And I get withdrawal from d8. Also - my sleep depth etc totally changes with d8 in a way that only gaba agonists produce in me. Took some last night and my watch is like “what did you do??! Your sleep was amazing!” — now I use it about twice a month just to catch up on sleep.
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yeah d8 has a lot less anxiety to d9, likely simply due to it's decreased psychoactive potency

they both effect me nearly the same in every way other than reduced anxiety/psychedelic properties in d8
 
Negentropic said:
yeah d8 has a lot less anxiety to d9, likely simply due to it's decreased psychoactive potency

they both effect me nearly the same in every way other than reduced anxiety/psychedelic properties in d8
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I’d agree except for the withdrawal which definitely does not occur for me w d9. Even equalized dosages I get much less anxiety and most especially electrical tics which are extremely indicative to me that my gaba signaling is having an issue.
 
Negentropic said:
yeah d8 has a lot less anxiety to d9, likely simply due to it's decreased psychoactive potency

they both effect me nearly the same in every way other than reduced anxiety/psychedelic properties in d8
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I’d agree except for the withdrawal which definitely does not occur for me w d9. Even equalized dosages I get much less anxiety and most especially electrical tics which are extremely indicative to me that my gaba signaling is having an issue. Eager to see more research in these areas speculating is useless ;/
 
cdin said:
I’d agree except for the withdrawal which definitely does not occur for me w d9. Even equalized dosages I get much less anxiety and most especially electrical tics which are extremely indicative to me that my gaba signaling is having an issue.
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I'm part of the camp which believes about 98% of cannabinoid (natural) withdrawal is psychological. It's weird and mostly psychological IMO.

I mean I certainly have lack of appetite, but the dysphoria of cannabis withdrawal has always been in my mind. If I'm motivated to quit it never comes and it feels like nothing - if I run out of weed and want more the psychological withdrawal and anhedonia can be very strong, but always ultimately in my mind.

Personally, I don't think cannabis has a physical withdrawal, but I'm not denying that it can't be absolutely awful at times.

I'm also comparing to heroin/fentanyl/benzo/alcohol withdrawal which might not be the fairest comparison.
 
Negentropic said:
I'm part of the camp which believes about 98% of cannabinoid (natural) withdrawal is psychological. It's weird and mostly psychological IMO.

I mean I certainly have lack of appetite, but the dysphoria of cannabis withdrawal has always been in my mind. If I'm motivated to quit it never comes and it feels like nothing - if I run out of weed and want more the psychological withdrawal and anhedonia can be very strong, but always ultimately in my mind.

Personally, I don't think cannabis has a physical withdrawal, but I'm not denying that it can't be absolutely awful at times.

I'm also comparing to heroin/fentanyl/benzo/alcohol withdrawal which might not be the fairest comparison.
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To be clear - I experience 0 physiological withdrawal from normal plant extract in high doses, dabs all day, 10g plus weed a day. The only thing that has brought this on was a few stints vaping pure delta 8. I 100% agree outside of less appetite, hard to sleep a few nights d9 and whole plant extract have 0 wd. Why I was shocked when d8 put me in such a weird way. Imo the different sub noids have pretty distinct pharmacological properties. I could always be wrong but the trp research seems to support at least differing downstream modulation effects (which might be all it takes)
 
cdin said:
To be clear - I experience 0 physiological withdrawal from normal plant extract in high doses, dabs all day, 10g plus weed a day. The only thing that has brought this on was a few stints vaping pure delta 8. I 100% agree outside of less appetite, hard to sleep a few nights d9 and whole plant extract have 0 wd. Why I was shocked when d8 put me in such a weird way. Imo the different sub noids have pretty distinct pharmacological properties. I could always be wrong but the trp research seems to support at least differing downstream modulation effects (which might be all it takes)
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interesting

personally I've always experienced more of a withdrawal from cannabis/d9 compared to d8-THC

but this is all highly subjective and anecdotal with many other things going on in my life at the time
 
Negentropic said:
interesting

personally I've always experienced more of a withdrawal from cannabis/d9 compared to d8-THC

but this is all highly subjective and anecdotal with many other things going on in my life at the time
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Likewise. Could be down to individual brain chemistry or also - unknown contaminants in the unregulated hemp noid supply. Just found a thc-p pen at head shop and bought it impulsively… not sure if I should hit it 😆
 
cdin said:
. Just found a thc-p pen at head shop and bought it impulsively… not sure if I should hit it 😆
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I love it. If you have any amount of tolerance it won't be overly intense. Those carts in the stores arent super strong but definitely get you high
 
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I've let my tolerance get out of hand several times doing over a gram a day for weeks on end. I've been able to quit for a few days at a time without much issue. I use about a gram of CBD for each day I'm not using and it relieves the majority of my sleeping and anxiety issues making it easy to fall asleep without THC.

I'm not sure how long some of the withdrawals might last as I haven't tested those waters yet. So far they seem as benign or more benign than delta 9.
 
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