My friend is curious about his response to codeine phosphate. 10 days after last using codeine - when he had used it three times before that over the course of 15 days - he took a dose 25% larger than his last. Expecting to have an experience at least as intense as his previous time, he was disappointed, with the drug working for much shorter than the previous times and the euphoria much less intense. My friend was under the impression that 10 days after a dose would be long enough to reduce tolerance enough so that a larger dose would bring about at least a similar effect, or even one better. Is he wrong or could there be other factors involved he is unaware of? If this is tolerance, how long must he wait between doses? Would potentiating counteract tolerance to some extent? Finally, would taking a substantially larger dose allow my friend to experience the same effects as gained from his earlier doses and would that then just increase tolerance even further?
Also, is my friend right in assuming that tolerance to codeine phosphate would also apply to dihydrocodeine?
Also, is my friend right in assuming that tolerance to codeine phosphate would also apply to dihydrocodeine?