From 90mg adderall to 50mg vyvanse!!! WTF!

[theGirlWithBlueHair]

Recommended. That doesn't mean he can't prescribe more: he can.

 

[Nixiam]

Some of us just like to know how the world works, that's all.

I think he's embarrassed by how technical you guys are.

I've learned significantly more about drugs and the biochemistry of the brain by watching people like the two of you talk than I ever have from highschool classes or textbooks.

 

[theGirlWithBlueHair]

I think he's embarrassed by how technical you guys are.

I've learned significantly more about drugs and the biochemistry of the brain by watching people like the two of you talk than I ever have from highschool classes or textbooks.

Whom are you referring to? And there is no need to be embarrassed. We were all novices at this at one point.

 

[Nixiam]

Haha! The two of you, b_d and Bloo Hair! That's what I meant by the two of you, my bad for lack of clarification.

Something about razordesign's comment just struck me the wrong way. Tis why I called it how I saw it.

On a side note, I wish I had the energy right now to invest in learning something, but I feel a bit too sick. Hopefully the concepts I've picked up on throught the duration of the thread sticks in my head.

Notice I said concept. They're bit like blocks, or syntax, and once you learn the essence of the language all you need is a reference book to be proficient.

Holy shit I make no sense right now.

 

[theGirlWithBlueHair]

No, who do you think is probably embarrassed?

You make perfect sense Don't worry

 

[Nixiam]

razordesignz.

Only reason I said that was because I somewhat felt his comment implied the extensive discussion as nonsensical, less you are a student of science.

Maybe I'm just too irritable, lady and gentle brahs.

 

[AlphaMethylPhenyl]

What's the fuss?

I've learned significantly more about drugs and the biochemistry of the brain by watching people like the two of you talk than I ever have from highschool classes or textbooks.

Great. Why don't you tell me which class of neurotransmitters work retroactively?

At how many MV must the membrane potential be to reach the threshold of activation?

What's an interneuron?

How do astrocytes participate in the metabolism of glutamate?

How do second messenger systems work, and do they function through channel or signal proteins?

What are the functions of sodium, potassium, and calcium ion channels in relation to action potentials?

What are neuronal refractory periods, and at what charge and how long do they last for?

The point is that apart from some simple math and names, which are all over the internet, bluelight can teach very little about the hard science behind understanding systems. On that last question, here's some reading: https://en.wikipedia.org/wiki/Refractory_period_(physiology)

 

[theGirlWithBlueHair]

Do you mean like retrograde neurotransmitters? if so nitric oxide and endocannabinoids.

You mean an action potential? about -50

sodium channels and calcium channels depolarize the cell, releasing neurotransmitters. Potassium channels, such as the inward rectifying potassium channels that GABA B receptors and D2 receptors are inhibitory and promote IPSCs and hyperpolarization. These ones are ligand gated. Sodium, potassium, and calcium channels can either be voltage gated or ligand gated and they can either cause neuronal depolarizations or hyperpolarizations which affect neurotransmitter release.

neuronal refractory periods are the brief periods after the generation of an action potential during which a second action potential is difficult to or impossible to elict.

Here is some very fucking detailed information: http://www.physiologyweb.com/lectur...onal_action_potential_refractory_periods.html

 

[theGirlWithBlueHair]

Oh I missed one of your points.

I can't possibly explain it better than this article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667713/

 

[Nixiam]

^I did say watching people like them talk teaches me significantly more than highschool has, or textbooks.

I hope it tells you what I've been taught.

What's it like, internet says -55mV

Neuron that transmits information between other neurons (the only one of these that I was familliar with)

I remember this word, astrocytes, from a previous post. Wayy back, in P&S I think? In relation to GABA, the astrocytes soak up glutamate, give the precursor of GABA, glutamine, to neurons. Wikipedia calls it the glutamate glutamine cycle, hopefull this is what you meant, otherwise I have no idea.

There is a general schematic that says it works like this:
Agonist activates membrane bound receptor
G protein activated produces effector
Effector stimulates second messenger synthesis
Second messenger activates intercellular process

And it looks like they function through signal proteins.

I'm going to pst now because I'm on mobile and my device has a habit of refreshing and destroying posts.

 

[Nixiam]

I honestly didn't feel like running around articles, but I feel smarter so thank you anyway.

Fekking abcessed tooth.

 

[theGirlWithBlueHair]

Fuck the internet. My neuropsychopharmacology book says exactly 50, which do you trust more?

Read the article some time, it is very in depth, if you are that interested. I didn't see your question about interneurons.

 

[Built240]

I tried more vyvanse today to see how I feel. Took my usual 50mg at 7:30am then took another 50mg at 10am. Usually with 50mg I start getting tired around 11ish but since I added that other 50 at 10am I felt really good until around 1pm then started getting tired again. I don't get why I only get about 3hrs out of a vyvanse. So at 1:30 I decided to take another 50mg. It's now 3:30pm and I just feel ok. Not tired but not that energized either.

 

[theGirlWithBlueHair]

It's because dopamine is inhibitory at the D2 receptor. This is s an incredibly powerful inhibitory response. (Same channel as the GABA B receptor.) And norepinephrine decreases its own releases via its presynaptic alpha 2 receptors. Some people are very sensitive to these effects.

 

[Built240]

It's because dopamine is inhibitory at the D2 receptor. This is s an incredibly powerful inhibitory response. (Same channel as the GABA B receptor.) And norepinephrine decreases its own releases via its presynaptic alpha 2 receptors. Some people are very sensitive to these effects.

Sorry I don't understand what this means? Would I have been better off dosing it different?

My Dr appt is on Wednesday. I'm confused on what to do. I like the feeling I have off of 50mg vyvanse but only for an hour or 2. When the 50mg converts to 15mg dex I can get by with that feeling for a few hours but not after that. Basically I need 15-20mg dex to last me around 5-6hrs and I'm good. I can get all my work done then and after that I'm fine being tired. I think I metabolize things faster than a lot of people so how can I assure I have 15-20mg Dex in me at all times for 5-6hrs?

 

[theGirlWithBlueHair]

It means that when dopamine activates the D2 it produced a sedating response instead of a stimulating one. I don't think you are metabolizing it. When you start getting more dopamine released it starts activating the dopamine receptors on the presynaptic cells which shut off dopamine release which will cut off sedation.

You should dose however works best for you.

 

[Built240]

So perhaps I'm getting too much dopamine causing me to be more sedated instead of energized. I wonder if maybe just sticking to extended release Adderall might benefit me more since it tends to increase the norepinephrine receptors more which are more responsible for energy

 

[theGirlWithBlueHair]

that doesn't make sense. it doesn't activate norepinephrine more.

in fact dextroamphetamine is MORE POTENT at inducing norepinephrine release as racemic ampehetamine, the other ingredient contained in the medication.

Both methamphetamine and delextroamphetamine are stronger at inducing neurotransmitter release than a racemic amphetamine (dextro/levo-amphetamine).

 

[belligerent drunk]

What's the fuss?
Great. Why don't you tell me which class of neurotransmitters work retroactively?

Why did you feel the need to post this? I think it is great if an online conversation gets people thinking, and perhaps provides some information that they would not otherwise come across. I believe there is no need to be aggressive about it.

Fuck the internet. My neuropsychopharmacology book says exactly 50, which do you trust more?

Read the article some time, it is very in depth, if you are that interested. I didn't see your question about interneurons.

From what I remember from my biochemistry lectures, the resting membrane potential value is not very well agreed upon. Some say it's -60, some say -70 mV.

So perhaps I'm getting too much dopamine causing me to be more sedated instead of energized. I wonder if maybe just sticking to extended release Adderall might benefit me more since it tends to increase the norepinephrine receptors more which are more responsible for energy

Using extended-release amphetamine may very well be your best option if your doctor is unwilling to prescribe more than 70 mg/day of lisdexamphetamine.

Another thing to the Girl with blue hair. It is thoughtful to recommend not dosing twice a day, but once instead. However, the pharmacokinetics of lisdexamphetamine, it seems to me, are very similar to plain amphetamine's after the initial onset period (the graphs, again). So if the OP had no problems with insomnia before, I don't think they'd start suffering from it with the same dosing schedule with lisdexamphetamine. Moreover, they were taking Adderall 3 times a day, which translates to significantly lower plasma levels than it all taken in one dose, and I think that taking the same amount of d-amphetamine in the form of lisdexamphetamine in one dose would result in too high a peak of plasma levels, followed by too sharp a decline.

 

[theGirlWithBlueHair]

Ho Chi Minh likes to be rude to people. He likes to take people's post and deconstruct them with his own blatant, misinformation that give readers incorrect ideas.

I was just telling you what my book stated.

I think the article agrees with what you said.