I Like to Draw Pictures of Random Molecules

[Nagelfar]

Artemisinin is the only drug I know with a peroxide bridge.

Resiniferatoxin too, but it's more of a, *ahem*, toxin than drug. But as per Paracelsus, it's the dose that differentiates.

The above I mentioned with a nitrogen bonding it a bit round-about:

 

[Dresden]

Methiolone

I've never seen a 1,3-dithiaindan group anywhere, and I've seen (and memorized) many organic chemical structures in my day. I also remember Rhodium saying the same thing, years and years ago at The Hive. The magic eight ball signs thus point to the impossibility of that molecule in this case, unless you can come up with a workable synthesis or extant counter example.

1,3-DITHIAINDAN (using the often very convenient replacement nomenclature that opsin also accepts)

To use replacement nomenclature, simply use oxa plus the correct locant number to insert an O in a molecule, thia for S, and aza for N. For example, 1,3-benzodioxole aka 1,2-methylenedioxybenzene becomes 1,3-dioxaindan.

1,3-DIOXAINDAN

 

[Dresden]

 

[Dresden]

The above molecule is the amphetamine version of histamine, basically. There's really no telling what it might do such as release large amounts of histamine possibly or act as a longer-acting histamine. It could possibly be quite unpleasant or toxic to some unknown degree and may be devoid of psychoactivity to boot. Sasha Shulgin dedicated a page or two to it in the back of TiHKAL IIRC and mentioned that its existence and pharmacological action were publicly unknown at the time of the publication of that book. Who knows? It may possess some yet as unknown patentable medical application, but that scenario seems unlikely at the this point as surely at least one multinational pharmaceutical company has investigated its action as of now, 2016, at least in house. Furthermore, I think anyone who tries to have an underground chemist make and test it will likely fail in that endeavor. Underground chemists tend to like to focus on such tried and true, crowd pleasing, high profit margin classics such as

2-METHYLAMINO-1-PHENYLPROPANE

1-(1,3-BENZODIOXOLE-5-YL)-2-METHYLAMINOPROPANE

&

N,N-DIETHYL-LYSERGAMIDE

While those inclinded to botany, supply us with the equally important

DELTA-9-THC

&

PSILOCYBIN

&

DIMETHYLTRYPTAMINE

This last little gem can, of course, be made synthetically but is a lot more easily extracted from Mimosa Hostilis root bark.

I posted all these classic drugs to emphasize that this late in the drug discovery game, all the very best psychoactive drugs have most assuredly already been discovered, and we should content ourselves with bringing them back into widespread circulation, rather than continue the research chemical fiasco--which did, nevertheless, help uncover a last few diamonds in the rough such as

MXE

MEPHEDRONE

&

alpha-PVP

These last three research chemicals are more than good enough to make it on the street drug black market IMO.

 

[DotChem]

Indozolam

 

[Nagelfar]

The best 'amylocaine/stovaine + dimethylaminopivalophenone' I think I've done yet. V. straightforward.

 

[Dresden]

Never seen a plain ol' N-S sigma aliphatic bond before like that, but hey, maybe that's just me?

 

[Dresden]

N,N-diethyl-1-pentyl-4-oxo-lysergamide

Note that the above molecule has the 1-pentyl indole and carbonyl indole-3-yl moieties necessary to conceivably function as a JWH cannabinoid. Of course, the 4-oxo group means that this molecule would have to be synthesized from scratch, which would be difficult though not impossible without going into its gritty, verboten on bluelight synthesis details. I have personally always noticed a visceral similarity between tje highs of LSD and cannabis.

 

[Draven26]

^^ The good stuff!

 

[Draven26]

Well.. Methamphetamine being the good stuff hahaha one of my favorite stimulants of all time! To me personally.. very clean.. you get shit done on the stuff and it makes you feel invincible! Granted it's a very disgusting drug because of all the shit it's made out of.. but damn it feels good!

 

[Draven26]

Going on 5 years of sobriety.. but the damn mind.. sometimes it still can't stop thinking about it from time to time! But I pray that I stay sober for the rest of my life.. I'm proud of my sobriety and I don't want to fuck that up!

 

[Draven26]

^^ Another one of my ole time favorites back in the day! Some good trips taken!

 

[roi]

...you don't understand this thread.

 

[Draven26]

...you don't understand this thread.

Then elaborate!

 

[Bagseed]

this thread is for chemicals not existing yet conceived by the posters...

 

[Doc Aliquot]

The idiot who first synthesized fenfluramine should have been given an epidural at C-2. A.H. Robins killed god-only-knows chubby housewives with that shit. I wrote a lot of script for it.

 

[Bagseed]

shaggyfin is back! http://www.bluelight.org/vb/threads...tchen-s-Spice-Cabinet?p=13570845#post13570845 :D

 

[DotChem]

What exactly makes a compound selective dopamine reuptake/releaser or selective serotonin-dopamine reuptake/releaser devoid of any norepinephrine activity? It is extremelly difficult to separate DAT and NET activity as the two transporters have virtually identical susbsttrate requirements. More difficult still is separating NET from DAT activities while retaning SERT activity intact. They are only 2 known compounds that are selective SDRI.
RTI-83

Ki values DAT(15nM) SERT(7.1nM) and NET(28,000nM).

and
UWA-101

Its chemical structure is very similar to that of the illegal drug MDMA, the only difference being the replacement of the α-methyl group with an α-cyclopropyl group...

My question is: those 2 molecules look so dissimilar it is hard to see what make them selective for DAT and SERT as opposed to NET. Is there a common motif I can't put my finger on that kills binding at NET transporter? second question: afaik there is no erowid experience reports on selective SDRI those, especailly the MDMA analog UWA-101 that is apparently now availaible in NZ/australia? correct me if I am wrong.

Comparison of SDRIs to SNDRIs https://en.wikipedia.org/wiki/Serotonin-dopamine_reuptake_inhibitor

Relative to serotonin-norepinephrine-dopamine reuptake inhibitors (SNDRIs), which also inhibit the reuptake of norepinephrine in addition to serotonin and dopamine, SDRIs might be expected to have a reduced incidence of certain side effects, namely insomnia, appetite loss, anxiety, and heart rate and blood pressure changes.^[1]..blablabla

 

[aced126]

What exactly makes a compound selective dopamine reuptake/releaser or selective serotonin-dopamine reuptake/releaser devoid of any norepinephrine activity? It is extremelly difficult to separate DAT and NET activity as the two transporters have virtually identical susbsttrate requirements. More difficult still is separating NET from DAT activities while retaning SERT activity intact. They are only 2 known compounds that are selective SDRI.
RTI-83

Ki values DAT(15nM) SERT(7.1nM) and NET(28,000nM).

and
UWA-101

My question is: those 2 molecules look so dissimilar it is hard to see what make them selective for DAT and SERT as opposed to NET. Is there a common motif I can't put my finger on that kills binding at NET transporter? second question: afaik there is no erowid experience reports on selective SDRI those, especailly the MDMA analog UWA-101 that is apparently now availaible in NZ/australia? correct me if I am wrong.

Comparison of SDRIs to SNDRIs https://en.wikipedia.org/wiki/Serotonin-dopamine_reuptake_inhibitor

I think it's not really fair to try seek comparisons between the 2 molecules as the first is a reuptake inhibitor and the second is a releaser. I know on Wikipedia it says it's a reuptake inhibitor but I doubt this claim. Butylone has clear acute empathogenic qualities and we all know that serotonin reuptake inhibitors cannot induce this.

 

[Nagelfar]

RTI-83

Ki values DAT(15nM) SERT(7.1nM) and NET(28,000nM).

Those aren't RTI-83s values, those are:

RTI-304s values. RTI-83s are:

(Ki)
55 nM @ DAT
28.4 nM @ SERT
4,030 nM @ NET

As for your question, it seems, if you look at the difference between DA & NE, that the ethyl or cis-propenyl (and in the amphetamine skeleton, the alpha methyl lengthened to a cyclopropane) somehow leaves the hydroxy group that alters NEs binding free to pry itself into the transporter that are otherwise blocked when it comes to DA or 5-HT; of course, that's an obvious non-explanation explanation, but such is QSAR.