So would you say that 100 ug/150ug of 1p would equate to about 100ug of LSD , it all kinda makes sense seeing as the paper that recently came out said that it had ~38% the potency of LSD in nice and rats (calculated from the head twitch number) . But subjectively I find a full tab of 1p to be pretty fucking strong but this maybe that I'm sensitive to the compound , plus I think the purity of the 1p for me anyway makes it superior to the classical lsd available to a majority of people now a days , even if it's still not just as strong visually it's all there mentally n that's what it's really about ?
I'm aware of thus paper, and actually have the PDF. To me it's not terribly convincing or impressive without gong into detail esterase levels in mice/rats .vs humans, activity comparison; in other words, trying to calibrate or compensate for species differences. However, my suspension of belief as to the accuracy of that paper is muted by the fact that I've never tried LSD, only LSZ, AL-LAD and 1P-LSD. Maybe once I try LSD I'd say that 38% is vastly overstated - who knows.
We do have to take into consideration whether;
1) 1P-LSD is hydrolysed in the stomach
2) Hydrolysis occurs in the blood volume via esterase activity
3) Differentail esterase activity
4) Differential enzyme levels
5) Whether transport of unhydrolyzed 1P-LSD to the brain occurs.
6) Efficacy if transport between individuals
7) Inherent unhydrolyzed activity
8) Brain esterase levels and/or activities.
HTR (head twitch response) is a very crude approximation of activity; in my opinion so crude as to be almost meaningless.
It's never going to pass ethics committee approval, but we need double blind comparison studies in humans to compare the two. Even then I suspect (as rave23 states) trip variation may make the two indistinguishable.
Tom