I'm ultra-sensitive to chems, generally, but I started with 10mg bumps & hammered 70mg the first night. I would not recomend this. It was bloody intense & long-lasting. Scared the shit out of me & I never did that much again. In fact, my doses of MXE went down every time I did it until I gave it up. Diss drugs just aren't my thang. I still occassionally use for anti-depressant effects, but I use almost inactive 1 or 2mg doses every hour or two through the day for the next day after-glow. Micro-dosing, I guess you'd call it.
I'd start with 5mg bumps, as advised above, & give them plenty of time to hit, because as you add to the hit, it changes & lengthens! Fascinating stuff, capable of producing remarkable realisation, but I'm done with it now. Remarkable the realisations may be, but the drug produces too much confusion to make use of the realisations. Each to their own, this one just ain't for me.