Nah, I may be manic depressively reckless, but not suicidal -- can't die just yet, since I haven't yet contributed what I have wanted. I'm interested because it has always remained an unanswered question to me as to what dosages would be considered highly problematic and dangerous. The sort of dosages where anti-drug propaganda becomes real, and the user genuinely
is playing Russian roulette with their life.
Has anyone anecdotally accidentally discovered where this point lay for themselves?
Most sites seem to say that 300-500mg is the beginning of this level with a tolerance.
I've found that the median LD50 blood morphine concentration is 1.5µg/ml for people over 25, with an
LD100 of 3.9µg/ml^(this is what I'm really interested in, a statistically meaningful average), but I don't know how to convert that into an initial dose of the diacetylmorphine ingested.
Let's see....
Humans have ~77ml/kg blood volume, I'm 85kg, so my total blood volume would be: ~6545ml of blood.
Diacetylmorphine -> morphine conversion has a 1:1 molar relationship.
3.9µg/ml x 6545ml = 25526µg = ~25.5mg
Mean street purity of heroin in Australia is ~66.2%*
25.5mg/0.662 = 38.5mg
Wow. So a person with no tolerance is pretty much guaranteed to end up in a coffin with less than half a point. Does that seem right? Seems a bit low to me. I think the street purity figures the police published are too high (probably because most busts were high up).
^Source for LD50/LD100:
http://www.ncbi.nlm.nih.gov/pubmed/17370507
*Source for heroin purity in Australia:
http://ndarc.med.unsw.edu.au/sites/default/files/ndarc/resources/T.R 079.pdf