I'm going to disagree with the other posters here and say, NO, MDMA will never permanetly lose it's magic. This is a rumor I believe and I see why it got started. People get old and they do the MDMA and they stop feeling the same. They might feel speedy or tweaky or just drunk, like the one poster mentioned. So, they end up maybe trying again and the same thing happens. So they give up on it. I can tell you that I had the most AMAZING roll I've ever had in my life just last week from some molly (Well it's pure MDA, but I feel lots of empathy and "body ecstasy" on it, so it may be mixed with MDMA) but yes, I've been rolling since the 90's and at points, thought I lost the magic as well.
The truth is, the magic is never gone, you just need to know how to find it again. Sometimes it might just not be there. It is a mystery still, as to exactly why, sometimes we just don't feel the magic and sometimes we do. It has to do with your body chemistry though and I can assure you that if I can have the best roll EVER, after 15 years of abusing MDMA then ANYONE can.
So, I hope from my extreme experience, this info will help clear up this rumor and that anyone can get the magic, no matter how much they abuse the drug in the past.
These are the triggers or situation regarding my BEST ROLL EVER-
I had only waited 1 week between my last roll, so no long wait was required. Infact, waiting long periods can actually REDUCE the quality of your roll. This is also a mystery to me, as to why. It seems random from person to person, and even with myself, in all my 100's of experiences, it has been random. Once I waited a LONG time between my roll and I got some MDMA confirmed, good beans. However for me, they just made me tired. NO MAGIC at all. Other times I waited and had some magic. But mostly the magic comes between this fine line, whatever this line is I don't know.
But another thing I did before this extremely magic roll, was I ate some chips and sour cream dip about 20 mins before hand. I only ate 1 and a half pills, so I didnt take a huge dose. Besides this I just sat around, didnt even have a good vibe or friends there and I still had the MOST MAGIC, INTENSE, ROLL EVER. I still can't believe it (how hard I rolled) as I've had so many (Well over 1000) experiences and this has to be at the top of the list. There was so much love and energy flowing through my body, I couldn't stop it. It was soooo pushy and I felt TOO GOOD at points, I found it hard to handle feeling that much ecstasy at once. But I didn't complain! And I'd gladly do it again! But I don't know what the heck the secret is to getting the magic EVERYTIME you roll? It seems random to me.
Piracetam may help to bring the magic back for you as well. Try it sometime, it's safe and that plays a part of the wierd body chemistry involved in all this.
So in short, the answer is "NO, Losing the Magic is not really a thing, just an experience" It doesn't have to be permanent.
If you want to know the BEST way to lose the "magic" just try rolling 4 or 5 days in a week, then do it once more after your drained. You should effectively kill almost all euphoria that the MDMA/MDA would have normally caused. So you not only lose the magic, but you lose the entire experience altogether! So, I really don't recommend what I said above, just making a point that you can lose the magic temporarily, obviously, from abusing the drug. But losing it for good is just not true. If these people kept trying, they'd get a magical roll again sooner or later. But people grow out of the drug usually, if it's not being "Magical" everytime they do it, then they have no need to do it any longer. I can understand that.
I also believe the Quality of the MDMA can make a difference, but this is not the main factor, as one could take the highest quality MDMA and still not have any magic. Some people also do NOT experience any magic their FIRST TIME EVER! So I thought I should mention this as well. I am one of those people! I did not roll my first time, even though I had the cleanest, most excellent MDMA at that time, far better than most of the crap you see now a days. I just felt speedy from it, no rolling, no magic. Did the same pill a week later and had unbelieved magic, and that was the first time I had ever rolled, even though technically it was the 2nd time I had taken the drug.
Also my girlfriend didnt feel any magic her first time either. So, again folks, it's all RANDOM!