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Opioids The Ultimate Opiate Potentiation Thread v2.0

Hey guys. Got some 30mg ABG morphinee sulfate ER's. I am a bit tolerant.

I swallowed and chewed up 5 last night with about 2 mg kpin... not much of a feeling, can tell i was on opiates, but barely.

This morning i took cimitidine (targamet) 30 min before and took my .5 kpin along with another 30mg and i didnt feel it right away or anything, but then i was soo much higher than last night.

Am i correct that cimitidine could do this to morphine ER tablets... and does anyone know how to change them into IR style... ( like whats the best bang for your buck ROA, cause with cimitidine it was good i believe) THANKS!
 
Edit: Hehe, nvm, I thought Sturdychinfilms' post (below) was questioning what ROA meant. I'll leave the below here anyway, someone will find it useful I'm sure :)





sturdychinfilms said:
Roa?
Click to expand...

Route Of Administration.

Basically means by which path the substance gets into the body;

- Sublingual (subling / SL) - under the tongue
- Buccual - on the inside of the cheek
- Intra-nasual (IN) - in the nose
- Intra-ventrical (IV) - in the vains
- Intra-muscual (IM) - into the muscle
- Intra-rectally (IR) - up into the rectum
- Sub-cutaneous (sub-cut / SC) - injected into the sub-cataneous layer of the skin (less common or hardly ever used recreationally)

These are the most common ROA's (there are more).
 
blazelate said:
anyone on the cimitidine and morphine sulfate ER intereaction...
Click to expand...

Taking cimetidine before morphine should decrease the rate at which the morphine is eliminated, therefore extending the duration of the effects.
 
i've got some diphenhydramine hydrochloride 50mg tablets, i gather i should take them 30-45min before injecting, but how many? just one?
 
yeah i would say one or two would work (no more than that tho)
take them and when you feel them "kick in" (you'll get slightly drowsy) then do your shot..
Have fun. Be safe!
%)
 
i against i said:
i've got some diphenhydramine hydrochloride 50mg tablets, i gather i should take them 30-45min before injecting, but how many? just one?
Click to expand...

HOOD's spot on, but I'd like to elaborate ;)

you can take them anytime really up to injection (or even right after). most people don't like more than 50mg, although some like me dig more 100-150mg.

does diphen affect you strongly/make you overly sedated? if so, probably want to stick to 50mg-<100mg. If not feel free to experiment. Most people find the diphen overpowers the opioid of choice at and over 100mg. but like I said there is always the freak such as myself who like 100mg+.

regarding tagamet - I find that it increased the intensity of the peak/high more so than actually extending the over all effects. But it might just be subjective, as maybe it is making my suboxone's peak (normally short) seem more intense by stretching it out a bit.
 
thanks peeps, i took one about ten mins before (fuck waiting!), tbh haven't really noticed any difference, new batch as well so no comparison.

don't know diphen's solo effects, never used before, but sleeping pills (seroquel, zopiclone, temazepam) that i've used never really seemed to do much. except total blackout at high doses =D
 
when it kicks in you should get more of a noddy feel to your high.. is it a good new batch that you got?
 
lost my supplier of dihydrocodeine, not good. i fucking love that opiate!

still got a shit load of tramadol (both immediate and extended release) and i'm one of the few people who find it euphoric.

hope i can get a new supplier for dihydrocodeine though... 8(
 
codeine and DHC never really seem to do anything for me beyond a mild mild mild warmth. but then again i've only tried them after using h, but even say, 2/3 weeks with no opiates still barely anything.
 
different strokes for different folks. could have something to do with how much you use too, but for one I do not like codeine. the high neither lasts long enough nor is powerful enough for my tastes. and for some reason codeine w/d has been significantly for me worse than heroin w/ds (longer).
 
Out of all the potentiators Captian H listed which single drug do you think potentiates opiates ( Particularly Oxycodone ) the best and strongest.
 
ime clonidine (but I he didn't post that)... come to think of it, I don't know what something like tagamet isn't up there is that list...
 
Opiate potentiation

My typical opiate of choice is Hydrocodone, which I use recreationaly about once a week. I have tried many different methods of potentiation, and have thus far found nothing that is truly effective in increasing the positive effects of the opiate.

Grapefruit juice: I have tried this on multiple occasions and have found it to make my high very uncomfortable. I would drink half a bottle (of the simply grapefruit) and my friend would do the same. We both reported the same effects every time we did this. I don't really know how to explain it other than it made me feel uncomfortable. Gave me an odd head feeling and did not increase euphoria what-so-ever. Perhaps someone else has had similar effects?

Promethazine: Just makes me really sleepy - no increase in positive effects. Does help with nausea and itching, however.

Benzo's: IMO they cloud the opiate experience for me. There is no synergy between the two, I just feel spaced out and high.

Alcohol: Never tried it. Not a fan of mixing acetaminophen and alcohol. Doesn't seem like it would do much other than cloud the high like benzos.

Weed: Is great for when I am on the "after high". Amazing synergy but only if consumed whilst coming down.

Diphenhydramine: Didn't really notice anything other than increased sleepiness (which I assume many try and pass off as potentiation) and decreased itching.

Never tried Dramamine or DXM, both of which sound pretty awful... especially DXM.

IME the best method of potentiation has been an empty stomach, breaking pills in half, and of course a week break. Does anyone have any insight on this? In your opinion is there anything worth while?
 
Intrinsic man said:
My typical opiate of choice is Hydrocodone, which I use recreationaly about once a week. I have tried many different methods of potentiation, and have thus far found nothing that is truly effective in increasing the positive effects of the opiate.

Grapefruit juice: I have tried this on multiple occasions and have found it to make my high very uncomfortable. I would drink half a bottle (of the simply grapefruit) and my friend would do the same. We both reported the same effects every time we did this. I don't really know how to explain it other than it made me feel uncomfortable. Gave me an odd head feeling and did not increase euphoria what-so-ever. Perhaps someone else has had similar effects?

Promethazine: Just makes me really sleepy - no increase in positive effects. Does help with nausea and itching, however.

Benzo's: IMO they cloud the opiate experience for me. There is no synergy between the two, I just feel spaced out and high.

Alcohol: Never tried it. Not a fan of mixing acetaminophen and alcohol. Doesn't seem like it would do much other than cloud the high like benzos.

Weed: Is great for when I am on the "after high". Amazing synergy but only if consumed whilst coming down.

Diphenhydramine: Didn't really notice anything other than increased sleepiness (which I assume many try and pass off as potentiation) and decreased itching.

Never tried Dramamine or DXM, both of which sound pretty awful... especially DXM.

IME the best method of potentiation has been an empty stomach, breaking pills in half, and of course a week break. Does anyone have any insight on this? In your opinion is there anything worth while?
Click to expand...

Out of all those, weed is the only one that worked for me...and trust me bro i tried everything to make those little pills work better. I wasnt a big fan of weed..so I just jumped strait to the hard stuff..which i do not suggest doing..ever
 
Alcohol induces the cyp2d6 enzyme that metabolizes codeine to morphine in the liver , I'm not sure what opiates your talking about but promethazine inhibits this enzyme so it makes it convert less , DXM also induces cyp2d6 so u should give that one a crack , same with alcohol (30-60mg DXM max , a drink or two half an hour before , and another half an hour after) anyone correct me if I'm wrong about any of this .
 
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