Pregnenolone sulfate is an excitatory neurosteroid that acts as a negative allosteric modulator of GABA-A and a weak positive allosteric modulator of NMDA receptors. ... Of note, pregnenolone sulfate also increases glutamatergic-simulated EPSPs in acutely isolated dentate gyrus hilar neurons of the hippocampus.
So theoretically it should play nice together with high dose pregabalin, extending its magic (which is supposed to be due to glutamate reuptake inhibition but that one regulates quickly and too gets overshadowed by upregulated enzyme for glu -> GABA.)
Any experiences? Need to order. Fuck, bluelight always wakes the experimentist in me.
I imagine that pregabalin could do the trick for GABA withdrawal, and/or together with another antiepileptic, like vaproate (I am currently on both, don't like the latter cause of its relative physical toxicity within therapeutic ranges - while one can abuse the hell out of pregabalin without damage - but they play nicely together. Doc likes valproate more but probably will switch again to just pregab.)
Pregabalin is able to
completely mask opioid withdrawal from moderate dependencies, I am currently wearing off from morphine/earlier methadone, former up to 600mg/d, latter up to 60mg/d.. with pregab 600mg/d could cut down from 480mg/d morphine straight to 240mg/d without nothing. Nothing. Then 180 - 120mg/d, now maybe 40mg/d. Next step is to kick with lope.
This is the second time I withdraw from morphine
and the second time I get away with. Time on morphine now maybe 1y, together 3-4yrs. First time was with memantine. And some breaks while on O-PCM, on that withdrawing actually feals great. Yeah. It feels great. You feel the numbing to fade away and being replaced with heavily euphoria.. just that this route is pro-psychotic.
Forget clonidine, even benzos. Imagine that pregab + memantine, both decently dosed over the course of some weeks together with tapering, add some lope if necessary, could well make the gold standard of opioid detoxification. Then wear off the pregab and contine on mem for receptor recovery / PAWS.
But back to topic. GABA, yeah - was my first withdrawal ever, they gave me like 3mg/d lorazepam in psych ward for social anxiety over 3 months, then got into a fight with some stupid wreck of alcoholic who was onto a girl I was friends with, sigh -- got restrained, 150mg chlorprothixene (first hallucinations ever, imaginated a complete person, interacted etc. and from a fucking
antipsychotic. Muscarinic antagonism. Wouldn't remain the last incident of this sort.) ... and cold turkey off benzos. Full on panic, insomnia for around 3 months and suspect it to having permanently altered my personality / brain structure towards more anxiety and panic which became generalized and one reason for me beginning to experiment, and to become hooked on some substances. Thanks, doc.
Now I'm partly immune to GABA w/d. Later they put me on zopiclone for sleep, also around 3 months straight, no w/d. Heavy drinking, no w/d just rebound. (Ab)using lorazepam - which lost its therapeutic effects at all but remains somewhat recreative, alprazolam is better but no access- no w/d. Yet I always watched to skip some days in-between with benzos, so maybe this cut it too.