100mg of O-PCE? Really? I can take 7mg and be pretty wonky. Can't imagine dosing anywhere even approaching that level. Do you have a bunch of disso tolerance? For most people even 60mg is WAY too much for O-PCE.
Yeah, I do mean it. I've taken at least 60mg with a decent amount of 2C-E as well. I'm not trying to make grandiose statements here. Think about DMT. A little is still pretty heavily disorienting without even hinting at what is around the corner via a full blown break through. Also think about mescaline. Would anyone have bothered to find the higher registers of it's dosages if there hadn't been folks in northern Mexico and the Andes taking megadoses of the stuff via cacti for ages? Not that I am suggesting that people utilize wanton disregard and just start recklessly taking oodles of whatever, but some substances do have a longer range of dosages than others. I mean LSD is pretty forgiving in that and so is ketamine, which this is pretty close to structurally.
However, people I think underestimate how much minor variations in structure do matter. 2C-B seems pretty forgiving in terms of taking more than generally advised. 2C-T-7 or 2C-P, not so much. I was at a MAPS conference years ago, where Dr.Nichols was giving a presentation on the 5HT-2 receptor site affinity that could be predicted by 2,5 substitution of phenethylamines. I asked him during and then again after the presentation as to what we could deduct about the toxicity of the various NMDA antagonists going around based on their structure. He dodged the question at 1st but I caught him coming out of the bathroom later and got a more direct answer which was "that toxicity is an unique phenomenon. That it relates to how something binds, it's exact path of metabolism, etc, and that the only method available to us to predict this is the science of systems biology." In other words, it would take being able to create an accurate computer simulation of the workings of the human body to be able to predict. So I am not trying to encourage people to throw all caution to the wind here by assuming that it is equally forgiving in terms of overdose. I have seen too many posts and trip reports that were posted by people engaging in wanton, reckless behavior. However, I have seen these effects manifest in a predictable enough fashion, that I am genuinely a little surprised by the pushback and making them wasn't my reason for registering and posting. Wanting to know more about MXM was.
As for my tolerance, my body is pretty good at metabolizing most things. With this class though, I feel like the risk of losing the magic and never getting it back is enough to keep me from using too often. So it isn't the same as my tolerance for herb, for an example. When I do K (and I mean vial dried, the stuff I come across anymore often just makes me sad due to low quality), about a quarter gram is my ideal intranasal dose and I do not redose. With MXP, I felt like I was only still learning about it when I ran out, but found 80-100mg quite interesting. Lower doses with mushrooms were also quite excellent. It seemed really adept at facilitating deep, profound emotional catharsis. With DXM, well, it has been a while, but I think that about 700-1200 or so mg was what I liked, with the upper levels being the best part. I used 3-MEO-PCP once but it was at a lower level. The risk of mania in the face of what it presented just wasn't worth it. Other than that my experiences with this class are via N2O and ether, which is pretty atypical.
On a side note, yours are some of the only trip reports, that I find interesting enough to read in full rather than just scan these days. I have been a lurker for years and have always valued your contributions. (Xorkoth)