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Cocaine Stability of cocaine HCL in solution

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dxdy

Greenlighter
Joined
Nov 11, 2014
Messages
2
How stable is cocaine HCL in a solution of anhydrous methanol or anhydrous isopropanol? I know that in aqueous solution there will be hydrolysis of the ester groups, but what sort of degradation occurs in dry alcohol?
 
I'd expect there would be transesterification with anhydrous methanol.
 
I thought that would happen instead of hydrolysis only if ingested. Would using anhydrous isoproponol help avoid this issue?
 
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