Finally got a chance to play with the 3-methyl-butyr-fentanyl. Product seems to be on point; it comes as a shiny white powder (similar to the powder butyr-fentanyl HCl) and is of high purity.
As for the chemical itself, it's almost exactly like butyr-fentanyl, but more potent. According to Wikipedia, adding a 3-methyl group to regular fentanyl makes it 10-15x stronger per dose, and I think a similar comparison can be made with its butyramide analogue. I would definitely say that 3-methyl-butyr-fentanyl is about 10x more potent, possibly a bit more than that, but from what I've gathered it is closer to 10x rather than 15x the potency. Obviously, one should start at a lower dose to play it safe. The subjective effects are pretty much indistinguishable from butyr-fentanyl, so it's still super euphoric, and so far I haven't noticed a difference in duration.
Just a note to anyone considering buying this: please be extremely cautious. Normal butyr-fentanyl is already quite potent and has killed plenty of people, so I can only imagine what will happen if this chemical gets into the hands of your average, idiotic teenager. On top of that, I think the increased binding affinity means it possibly is even more addictive, raises tolerance even more, or even is harder to reverse in case of overdose. Take it with a grain of salt, but I've read before that (non-butyramide) 3-methylfentanyl cannot be reversed by naloxone, and I'm pretty sure I've heard someone say the same thing about butyr-fentanyl too.
Would be four I think if diastereomers are considered. It seems that the cis(+) isomer of 3-methylfentanyl is the most potent by fairly significant margins. Maybe these margins could be expected to be greater for 4-methylbutryfentanyl. Would increasing the amide chain length possibly bring sterics for the isomers into greater play and possibly result in a greater gap in potency?Do we know which isomers are produced? I thought 3-methylfentanyl had at least 2 isomers.
From my personal experience, butyr-fentanyl gets readily displaced by naloxone, even with nasal administration. But it was just a few mg too much if an overdose at all, so maybe its another thing when someone takes more.but I've read before that (non-butyramide) 3-methylfentanyl cannot be reversed by naloxone, and I'm pretty sure I've heard someone say the same thing about butyr-fentanyl too.
I pray to God you are not titrating powerful fentanyl analogues with those math skills! Fentanyl is general rated 100x Morphine, though I find that a separate topic for debate and would feel 80X is more accurate yet still a generous rating erring on the side of safety when converting which is never a bad thing when dealing with compounds with LD50's that make VX nerve agents LD50 seem somewhat tame in comparison... Carfentanyl for example weighing in at 10,000X morphine & is active at 1 nanogram. That stuff can kill you even if you know what you are doing! As for your math, Fentanyl is 100X and 3-MF is 10-15x that would have you dirt naping folks converting at 200-375X when it's 1000-1500x? The shit scares me, I've seen a few need air for 20min...Isn't fentanyl 80-100x morphine? If 3-MF happens to be 10-15x more potent than fentanyl, shouldn't 3-MBF be 10-15x more potent than BF as well, making it 2.5-3.75x fentanyl or 200-375x morphine?
I think Cronos was referencing jammin83's admitted error; 76× (as opposed to) — 250×, that roi corrected, and just happened to quote roi.Cronos: it seems like you are forgetting about the butyryl part here.
Yes your 1000-1500x would be correct for 3-methylfentanyl (3-MF), but this is 3-methylbutyrfentanyl (3-MBF), stepping down the potency ~4x compared to 3-MF... so roi's math seems fine.