N&PD Moderators: Skorpio | thegreenhand
As for your 3,4,5-halogenated amphetamine comment, neither one of us knows if they will substitute for mescaline or not (though we both have our hypotheses about it, though mine is tentative I would say)
I'm not sure if I understand what you mean. Do you mean the aromatic C-Cl bond being weaker than C-F? In my opinion that's the least important thing here. p-iodoamphetamine is less neurotoxic than p-choroamphetamine, so how would you explain this discrepancy? All halo groups withdraw electron density from the aromatic ring, so clearly that's not where the difference is. I suppose it all comes down to halo group size and C-X bond polarization and the partial charges it creates. p-methylamphetamine doesn't seem to be neurotoxic and methyl group is similar in size to chloro group, bromo and iodo are considerably bigger and their C-X bonds are less polarized.