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I Like to Draw Pictures of Random Molecules

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The stats! :* Links to the results last for around a month, not more, as I noticed with the posts of my "Gaffy's analog act". Replacing them on the usual would be a real hassle. What i can do is post just the image and comment on the % of binding probability underneath!
 
VcPJyQV.jpg


So I was wondering, just how much difference is there between 3,4 MD and 4,5 MD. As you can see in the picture, the double carbon bond position differes from one to another's, maybe that's what's wrong with today's MDMA?
 
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there is no real carbon double bond because in an aromatic ring system, all the electrons are delocalized....
 
sekio said:
^ I could swear a very similar compound was in Lenz's Opiates. Don't think they were more effective than pethidine though. I know that the meta-isomer of pethidine is less effective.
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Yes, piperidine homologues of cocaine have been studied multiple times.
 
Bagseed said:
there is no real carbon double bond because in an aromatic ring system, all the electrons are delocalized....
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Thanks bagseed, what is your explanation for the difference between MDMA made from safrole and the one made from MDP2P? One is euphoric, stimulant and enjoyable, the other is stressful, disphoric and makes you tired.
 
3,4 MDMA and 4,5 MDMA are actually the same molecule. Playing with molecular models should establish that.

qwmtuOD.png

These two MDMA molecules were each made by a different synthesis, can you tell which?
 
Does the angular curve inbetween the carbons then explain the difference between MDMA made from MDP2P and MDMA made from safrole? Just like Meth made from Ephedrine being like 10x times better than meth made from p2p.

Any idea for another M1-4 compound? Different structure?
 
Does the angular curve inbetween the carbons then explain the difference between MDMA made from MDP2P and MDMA made from safrole?
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No. You seem to forget that most MDP2P is made from safrole. In any case, racemic MDMA is racemic MDMA. It would do you good to learn about the 3d structures of organic chemicals: the little line drawings are not 1:1 representations of how these compounds exist in space.

Just like Meth made from Ephedrine being like 10x times better than meth made from p2p.
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Ephedrine is a chirally pure natural product, so meth produced from it is 95% dextro-methamphetamine. Methamphetamine from P2P is only 50% as it's racemic.

Any idea for another M1-4 compound?
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Why, do you like salivation? The effects of muscarinics are not known to be very pleasant.

I suspect your compound is actually an antimuscarinic, i.e. atropine-like. Those are not known to be pleasant. Compare the structure of BZ and others. The dudes at Edgewood Arsenal pretty much beat you to the punch for antimuscarinics.
 
sekio said:
I suspect your compound is actually an antimuscarinic, i.e. atropine-like. Those are not known to be pleasant. Compare the structure of BZ and others. The dudes at Edgewood Arsenal pretty much beat you to the punch for antimuscarinics.
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Do you have an example? :)
 
I am suprised you aren't familiar with atropine-like deleriants? The muscarinic antagonism is part of what produces the CNS deleriant properties.
Some antimuscarinics are are useful agents to stop things like excess salivation but must be carefully dosed to avoid strange hallucinogenic effects.
BZ was developed as an incapacitating agent for that reason; a dose is measured in the low milligrams and will lead to a 2-3 day long delerious fugue state.
Similar effects are noted in intoxication with solanaceous plants like henbane, datura, brugmansia, etc. and also from drugs with anticholinergic acitivity like diphenhydramine.
iNIsy4t.png


Funny enough, one of the "antidotes" to BZ toxicity is sarin or similar nerve gas in a very carefully measured dose... the idea being that the nerve gas will inactivate some of the acetylcholinesterase enzymes, increasing cholinergic signalling, and overcoming the blockade of muscarinic receptors by BZ. Obviously this is not clinically reccomended but...
 
I actually am familiar with atropine, and have been intoxicated not so long ago with what must have been in the same trend as what you posted.. Very not funny.. Anyway, I will delete my post then, I'm not into making poison :)
 
Could M1-4 antagonism to a small extent as with cocaine be a cause for the inhibition it produces?
 


Found a cool javascript chemdraw thing... used to have to pirate the software to get features like structure to name. Anyway smoked some a-pcyp and started thinking about modifications to it... its a very potent stimulant. One of the most potent ones i've tried, almost like MDPV..
 
Cool, we've tought of these already, this one should be the winner:
 
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OK, as of today, no nore STP posts here, please. Take those to the molecular doodles thread.

GE0Jxyd.png


Apparently this is active at 5HT2a?
 
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Is just using STP to use ChemAxon ok? Like in my post above?
As for unlikely Psychedelics, here's one I drew some time ago:
BO8PKD7.png


Btw Sekio, is the IUPAC in my signature correct? If not can you name one please?
 
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Chemdraw chokes on it, and it doesn't look like a valid IUPAC name, no.
Is this what you meant?
2yK7GgE.png

The 3 chiral centers are 2, 3, & 4. Usually if you have a racemic compound specifying (RS) is unneccesary - any unspecified chiral center is assumed to be racemic.

Also, I would prefer you stick to smaller images posted using the [‍img][‍/img] tag.
 
I meant the picture I committed to naming GAFFY in the Name-A-Molecule thread ^^ This one:

fMnByGa.jpg



A-AVP

FS22Xut.png


Alpha-AziridineValeroPhenone


Edit:I just realised the difference between pyrrolydine and pyridine.. I will update that asap!

Done 👈
 
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