I can't find anything on what the therapeutic dose is if there's such a thing. I would think 1 gram is a bit much. I'm not familiar with it til recent news about it. Why anyone would use it as cutting agent or blend agent with heroin is mind boggling. Heroin is already as is, so why the fentanyl mixture? Would fentanyl by itself work like heroin? Can the feeling or high pass off as a heroin high?