I've always found good ole Advil or Ibuprofen to be about as good as it gets for joint/arthritis (and muscular pain too) type pains, surprisingly enough. BTW, if what you're looking for is a reduction in pain, Immodium is not going to do the trick. That is usually taken to reduce WD discomfort, not to treat joint pain. And as was previously mentioned, comes with its own set of problems/issues, especially when taken in quantity. Good luck OP!