Study Anabolic Steroids and Oxidative Stress

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alan2102

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Toxicol Rep. 2017 Jun 8;4:282-286. doi: 10.1016/j.toxrep.2017.05.005. eCollection 2017.

Use of anabolic androgenic steroids produces greater oxidative stress responses to resistance exercise in strength-trained men.

Arazi H1, Mohammadjafari H2, Asadi A1,3.

Abstract

The aim of this study was to determine the effect of anabolic androgenic steroids (AAS) use on oxidative stress responses to a single session of resistance exercise in strength-trained men. Twenty-three strength trained men, with 11 self-reporting regular AAS use and 12 self-reporting never taking AAS (NAAS) volunteered to participate in this study. Blood draws were obtained pre and post resistance exercise in order to evaluate changes in oxidative stress biomarkers levels (i.e., 8-hydroxy-2-deoxyguanosine [8-OHdG], malondialdehyde [MDA], and nitric oxide [NO]), antioxidant defense systems (i.e., glutathione peroxidase [GPx] and catalase [CAT]), and glucose (GLU) levels. The AAS users had higher level of 8-OHdG (77.3 ± 17 vs. 57.7 ± 18.2 ng/mg), MDA (85.6 ± 17.8 vs. 52.3 ± 15.1 ng/mL), and GPx (9.1 ± 2.3 vs. 7.1 ± 1.3 mu/mL) compared to NAAS at pre exercise (p < 0.05). Both the experimental groups showed increases in 8-OHdG (p = 0.001), MDA (p = 0.001), GPx (p = 0.001), NO (p = 0.04), CAT (p = 0.02) and GLU (p = 0.001) concentrations after resistance exercise, and the AAS group indicated significant differences in 8-OHdG (p = 0.02) and MDA (p = 0.05) concentrations compared with NAAS users at post exercise. In conclusion, use of AAS is associated with alterations in immune function resulting in oxidative stress, and cell damage; however, high-intensity resistance exercise could increase greater oxidative stress biomarkers in strength-trained men.


KEYWORDS:

Anabolic; ROS; Strength exercise

PMID: 28959650 PMCID: PMC5615127 DOI: 10.1016/j.toxrep.2017.05.005
Free PMC Article


 
A couple of quick remedial ideas:

https://www.ncbi.nlm.nih.gov/pubmed/28736511
J Int Soc Sports Nutr. 2017 Jul 21;14:24. doi: 10.1186/s12970-017-0181-z. eCollection 2017.
Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial.


https://www.ncbi.nlm.nih.gov/pubmed/22080314
J Strength Cond Res. 2011 Dec;25(12):3448-55. doi: 10.1519/JSC.0b013e3182162f2b.
Creatine supplementation decreases oxidative DNA damage and lipid peroxidation induced by a single bout of resistance exercise.
 
Thanks mate! Nice post :)

Hope you're doing well?
 
A brief interpretive thought: Both AAS and resistance training cause oxidative stress. This is not bad, necessarily. SOME oxidative stress is hormetic, and induces a super-compensatory activation of scavenger (antioxidant) enzymes. This super-compensation may actually be one mechanism of anabolism. Anabolic metabolism is essentially reductive; catabolism is oxidative. So, a brief episode of oxidative stress may stimulate compensatory reductive/anabolic processes, in the same way that brief episodes of severe muscle stress (resistance training) do the same. Much has been made of the idea that one must avoid antioxidant supplements in order to get the benefits of exercise training. Perhaps true, if we are talking about before or during the bout. AFTER, however, may be a completely different story. After the bout, one would want to augment the reductive/anabolic processes and thereby encourage/augment super-compensation. This would perhaps be the time to load up on MSM, taurine, vitamin C and E, polyphenols, etc., etc. And, in accord with all that, perhaps overtraining is a condition of (catabolic) oxidation and oxidative stress running wild -- badly in need of antioxidant supplementation (and, of course, just rest!).
 
I definitely agree the science shows potential patterns wrt anabolic status vs oxidative status, and it clearly affects all kinds of signalling and expression cascades. I suspect, as with a number of findings, the temporal pattern of antioxidant relief would play a role, though in some instances post-exercise augmentation seems to be as unhelpful as pre-workout.
 

As I was saying...


Redox Biol. 2017 Aug;12:285-290. doi: 10.1016/j.redox.2017.02.015. Epub 2017 Mar 3.
Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve.

Radak Z1, Ishihara K2, Tekus E3, Varga C4, Posa A4, Balogh L5, Boldogh I6, Koltai E2.
Author information

Abstract

It is debated whether exercise-induced ROS production is obligatory to cause adaptive response. It is also claimed that antioxidant treatment could eliminate the adaptive response, which appears to be systemic and reportedly reduces the incidence of a wide range of diseases. Here we suggest that if the antioxidant treatment occurs before the physiological function-ROS dose-response curve reaches peak level, the antioxidants can attenuate function. On the other hand, if the antioxidant treatment takes place after the summit of the bell-shaped dose response curve, antioxidant treatment would have beneficial effects on function. We suggest that the effects of antioxidant treatment are dependent on the intensity of exercise, since the adaptive response, which is multi pathway dependent, is strongly influenced by exercise intensity. It is further suggested that levels of ROS concentration are associated with peak physiological function and can be extended by physical fitness level and this could be the basis for exercise pre-conditioning. Physical inactivity, aging or pathological disorders increase the sensitivity to oxidative stress by altering the bell-shaped dose response curve.

PMID: 28285189 PMCID: PMC5345970 DOI: 10.1016/j.redox.2017.02.015
Free PMC Article


 
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