dopamimetic
Bluelighter
- Joined
- Mar 21, 2013
- Messages
- 2,070
"Permanently" upregulated 5-HT2a after using of THC & Psilos on top of an O-PCM binge
Hi folks,
the following is a personal issue of which I simply don't know where or with whom to talk about. Of course it should be a doctor, and I know that bluelight can't nor shouldn't replace one, but I am afraid of that for now because of how some people react when it comes to hearing voices.. they aren't exactly voices, more an asynchronous second train of thought over which I only have very limited control (but can talk with, sometimes, also in limited amount). No pitch, just words.
This started when I was addicted to O-PCM and took a "Dutch tour". One or two joints on day one, another one and psilocybe tampaensis on day two. Of course mixed with my beloved PCM, and contrary to the plan I emptied the whole box of truffles within a few hours (should have known better, yay). None of these were new to me, had good experiences with truffles years ago and not so good ones with weed but every drug alone was tolerated. Also I have mixed O-PCM before with a handful of other things although never these other two.
The first hours nothing unexpected happened, some delusions but no real hallucinations. Then black-out, next thing I remember is being out in the stairwell, thinking it was a psych ward where I would have lived forever and just woke up off a dream of my real life. More black-outs followed, after 12h or so I was back to reality but felt weird. Nothing too special, just that it lasts up to today (10 months). The voices come and go, they are worse when I am stressed and it takes just a tiny fraction of what I used to tolerate, for extreme stress reactions like stuttering, headache, pounding heartbeat, fucking strong anxiety. Concentration's on holidays and cognition slows down too often.. social withdrawal etc, guess it's your usual negative/positive symptoms..
Antipsychotics don't cut it, some with 5-ht2a antagonism do lower the frequency though (chlorprothixen, dipiperon). Risperidone 2mg caused a worsening (over 10 days). Recently I found CBD to be more helpful. Lisdexamphetamine helps with the cognitive issues, but does worsen the voice phaenomen when coming down .. SSRIs did just increase inner tension until I started the dipiperon. Pregabalin doesn't to help on the long run either.
My theory is that I experienced some kind of seizures due to overexcitation mediated by (also) the 5-HT2a and CB1 receptor couple, and glutamate autoreceptors blocked.. in an oversimplification. Is this possible? And what might help?
Oh, missed something. I am on morphine maintenance, 300mg. Was an attempt to get me off the PCM that didn't hit it, have been taking both for a while until the symptoms got too bad. I can't withdraw at the time being because even before the runny nose these damn thoughts and extreme tension set in. In retrospective I feel like the opioids (bupe first, then morphine) potenciated the (acute) delusional effects from dissos.
I'd be thankful about some supplement working of course. Sarcosine, Agmatine maybe?
I am taking a B-complex now and will switch to a multivitamine after that.
Otherwise from the prescription drugs, a 5-HT2a reverse agonist maybe (does one exist that is available)? Rimonabant being a CB1 reverse one. Or rather glutamatergic modulators, I made mixed to good experienced with memantine against overexcitability years ago..
I won't experiment with more than supplements for now, just want to understand what's happened or might have happened, to be able to convince a doctor to help me more than just label me a psychotic episode..
Thanks!
Dopa
Hi folks,
the following is a personal issue of which I simply don't know where or with whom to talk about. Of course it should be a doctor, and I know that bluelight can't nor shouldn't replace one, but I am afraid of that for now because of how some people react when it comes to hearing voices.. they aren't exactly voices, more an asynchronous second train of thought over which I only have very limited control (but can talk with, sometimes, also in limited amount). No pitch, just words.
This started when I was addicted to O-PCM and took a "Dutch tour". One or two joints on day one, another one and psilocybe tampaensis on day two. Of course mixed with my beloved PCM, and contrary to the plan I emptied the whole box of truffles within a few hours (should have known better, yay). None of these were new to me, had good experiences with truffles years ago and not so good ones with weed but every drug alone was tolerated. Also I have mixed O-PCM before with a handful of other things although never these other two.
The first hours nothing unexpected happened, some delusions but no real hallucinations. Then black-out, next thing I remember is being out in the stairwell, thinking it was a psych ward where I would have lived forever and just woke up off a dream of my real life. More black-outs followed, after 12h or so I was back to reality but felt weird. Nothing too special, just that it lasts up to today (10 months). The voices come and go, they are worse when I am stressed and it takes just a tiny fraction of what I used to tolerate, for extreme stress reactions like stuttering, headache, pounding heartbeat, fucking strong anxiety. Concentration's on holidays and cognition slows down too often.. social withdrawal etc, guess it's your usual negative/positive symptoms..
Antipsychotics don't cut it, some with 5-ht2a antagonism do lower the frequency though (chlorprothixen, dipiperon). Risperidone 2mg caused a worsening (over 10 days). Recently I found CBD to be more helpful. Lisdexamphetamine helps with the cognitive issues, but does worsen the voice phaenomen when coming down .. SSRIs did just increase inner tension until I started the dipiperon. Pregabalin doesn't to help on the long run either.
My theory is that I experienced some kind of seizures due to overexcitation mediated by (also) the 5-HT2a and CB1 receptor couple, and glutamate autoreceptors blocked.. in an oversimplification. Is this possible? And what might help?
Oh, missed something. I am on morphine maintenance, 300mg. Was an attempt to get me off the PCM that didn't hit it, have been taking both for a while until the symptoms got too bad. I can't withdraw at the time being because even before the runny nose these damn thoughts and extreme tension set in. In retrospective I feel like the opioids (bupe first, then morphine) potenciated the (acute) delusional effects from dissos.
I'd be thankful about some supplement working of course. Sarcosine, Agmatine maybe?
I am taking a B-complex now and will switch to a multivitamine after that.
Otherwise from the prescription drugs, a 5-HT2a reverse agonist maybe (does one exist that is available)? Rimonabant being a CB1 reverse one. Or rather glutamatergic modulators, I made mixed to good experienced with memantine against overexcitability years ago..
I won't experiment with more than supplements for now, just want to understand what's happened or might have happened, to be able to convince a doctor to help me more than just label me a psychotic episode..
Thanks!
Dopa
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