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Stimulants Poor Oral Bioavailability and Irritable Bowel Syndrome (IBS)

pharma-sutra

Bluelighter
Joined
Apr 15, 2012
Messages
182
Given due to the symptoms that are often portrayed: dehydration, migraines, excessive vasoconstriction, and increased bowel movements (oily, watery solid excrement), I've come to conclude that there might be a love-hate relationship with the add medications I'm prescribed.

These symptoms have been greatly exacerbated recently, where I cannot reap the full potential of these amphetamine-based and methyphenidate-based medications. It has gotten to the point where as soon as I dose, I would feel the come-up very quick and then it suddenly flushes out of my system within an hour. Then all that I'm left with are migraines and chapped lips. Little experimentation of trying to hold in the bowel purging resulted with slight improvement. Which lead me to try to utilize Tums (calcium carbonate), a popular anatacid used to potentiate or extend the duration of stimulants. Yet to no avail.

I've mentioned this to my doctor several times, and the doc simply told me to ease off the medication and use sparingly. However, I rarely take them. The only time I would dose is when I really need to rack up the momentum when I'm swamped with a lot of work. Never did I take more than recommended dosage either.

So onto more self-experimentation, decision was made to use PepcidAC (famotidine), another popular antacid, to counteract these negative side-effects. After taken famotidine an hour prior to ingestion of 5mg dexedrine IR, I can personally attest that it has done it's job and the dex is gradually hitting me (instead of coming up really fast and then flushed out). 4 hours later, redosed 2.5mg dex IR. The therapeutic effects are finally working, firing at all cylinders. 7.5mg had lasted me over 9 hours, where I could finally get the long-overdue work finished. Usually, where there wasn't famotidine in the equation, even a 30mg vyvanse cap wouldn't even have lasted half that duration.

An odd observance that I also noticed is that the concoction of famotidine with dexamp is fairly anxiolytic as opposed to the regular anxiogenesis. And of course, no messy bathroom runs. So out of curiosity, I wanted to asked if there is a reason for such occurrence? Strangely enough, a familiar a scenario occurs when I drink alcohol. Without famotidine, I am left with swollen, itchy hands and an instant rose-flushed countenance even after just one alcoholic beverage. After two or three drinks deep, I would feel the strong urge to regurgitate. And if I allow myself to vomit, all the physical side-effects diminish (swollen palms and reddened face) but the "hangover" migraine quickly ensues.

This has been really troubling for me. I want to know why my body acts this way. It's probably something to do with the pH balance of my stomach. It would be a huge help if someone could direct me to some remedies as well determine what this might be and it's underlying cause.
 
Take a break the high gets suckyer the more often you do it. Loperamide will stop your ibs but will make the dehydration worse.
 
is it because of poor metabolism or high metabolic rate? and is there a correlation between XR medications vs. IR? because adderall xr, dexedrine xr, and especially vyvanse tend to flush out my system fairly fast as opposed to their IR counterparts.
 
I asked my shrink why I can't just go on IR Adderall, I mean gosh she has me on it twice a day, after complaining the XX wears off after 3-4hrs if my lucky. So she have gave another RX for PM, ,my insurance wanted all this prior auths done and good reason...I think the IR last longer if not just as long as RX and smoother
 
I asked my shrink why I can't just go on IR Adderall, I mean gosh she has me on it twice a day, after complaining the XX wears off after 3-4hrs if my lucky. So she have gave another RX for PM, ,my insurance wanted all this prior auths done and good reason...I think the IR last longer if not just as long as RX and smoother

Yea IR tends to be "smoother" in the respect that you don't feel the distinct peaks if you know when to (re)dose. Vyvanse is the only medication that tends the last for quite a while, but lacks the punch of the focus and energy from IR. One of the biggest flaws about XR is the residual stimulation. One can only get so much sleep if you happen to dose a bit later in the day.

(btw) famotidine seems to potentiate amphetamines by a ten-fold.
 
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