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Opioids do different opiates really have different highs or is the dose all that matters ?

EEhouseEE

EEhouseEE

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Jan 20, 2010
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425
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Canada
so the title is pretty much my question. For example some people always say they like oxycodone more than hydrocodone but is the high acctual any different or is it just cause oxycodone is more potent so your acctually having a stronger dose?. I only ever tried oxycodone and codein and they seemed like the same type of high but codeine was weaker only cause i had a less dose.

I am just wondering how diffetent can opiates compared with each other really be, dosnt the high all depend on the dose ?
 
Different opioids do in fact present different highs, but the difference is something that only becomes even mildly obvious once you have a rather large experience with them. Most people who are/were addicted can tell the difference, it would seem, most easily. To the average opioid naive person, unless one takes low doses, the high from hydrocodone isn't significantly different from heroin (in effects of euphoria and the nod I mean; of course there are a lot of obvious differences, but you get my point - both drugs share certain foundational similarities making them both fall under the category of drugs opioid).

The high does not just depend on the dose, not at all. That being said, opioids are all called opioids because they have the same essential character - that being, I believe, that they feel like/act similar to morphine. I mean, all opioids produce essentially the same high, but there are certainly differences in effects (other than half life/longevity of the high I mean), even if they can be mild and somewhat subtle at times.

Someone correct me if I'm wrong on that last bit.
 
The high will feel very similar IMO. Different opiates do feel different, one factor is how fast the onset of the drug is and how long it lasts. Oxycodone and hydrocodone are similar in that respect, they are both fast-acting full agonist opiates. Since you come up very fast you feel the high moreso than methadone for example. Methadone has a very slow onset and long halflife compared to oxyocodn or heroin, so even thogh it's a full agonist the high really does not compare (if you wanna call ita high).

Honestly when I used to sniff, I was sniffing 10-12 oxycodone 30mg IR pills daily, and I started to fuck around wit dope since I could get 4 bags for the price of one pill. The first time I was like taking these little matchbook sniffs and I was like scaredf it was gonna be mad powerful lol. In my head heroin was heroin.. I didn't realize how much quality could vary. I was more conecnedf with the dude giving me all the bags I paid for than what stamp/contents it had. So the first few times I tried dope I acutally ended up goin back to oxy because it got me fucked up, and the dose was guaranteed to be the same every time.. it was reliable ya know..while I was yeilding no results with H probably because I was buying from random crackhead lookin dudes. Then one time I get this stamp called 100%, and that's when I realized the potential of heroin. I could sniff a single bag and it was as good as sniffing a 30mg oxy IR if not slightly more. So for a while instead of spending triple digits PER DOSE I was able to reduce that so drastically. I quickly realized that the quality of dope can vary so much.

Anyway,.as far as the way the high feels, sniffing heroin and sniffing oxycodone felt so slimiilar.. I found heroin to maybe last slightly longer than oxy when sniffed but essentially IMO it felt so much the same.. like I sniffed oxy that just tasted different. Shooting was is a whole nother story.. I never tried shooting one of the oxy ir's but shooting kind of brought the high to a different level. I had lost teh ability to nod out and shit.. but that all came back. Anyway I went in ujust like everyone else does.crossing every line I have drawn for my self rationalizing 'trying IV H just a few times.' Right. I probably have only sniffed less than a handful of bags in the past few years lol. I just feel that its so wasteful.
 
In comparison to most opioids, I find oxycodone a bit more stimulating than sedating, especially when used intranasally. But this is just me (others find it to be more like the above poster, while yet others find it a bit more stimulating like me, while YET other find it to be different from how either myself or the above poster finds it)...

OP - given the inherently subjective nature of all recreational drugs, anecdotal responses are going to be of limited value.

But I guess they would point two a sort of paradox, which of course isn't much of a paradox at all:
1) all opioids have to feel somewhat similar as they're all of the same family: opioid
2) each opioid has it's own specific character given different ROA, BAs and subjective effect (different people respond differently)

So they're all the same
Yet each of them is different

I love stuff like this, where the absolute meets the conditional, the universal the relative, the common the distinct. Can they be both the same and different at the same time? OF COURSE: Some aspects of all opioids are essentially the same (i.e. they all are kind of like morphine), while they are also each distinct, each opioid possessing its own character traits (that are unlike those of morphine).

Make sense?
 
Hydrocodone for me after taking a few weeks off I'll get a strong "pins n needles" feeling all over my body while oxycodone (only done it once) just gave me a strong head high. However after that first time back the hydro "PnN" feeling goes away (for the most part) and I'm left with a less intense oxy feeling.
 
Highs are definately different... I can tell that and I'm not what would be deemed on here as a heavy user. The above link is somewhat helpful but its only listing the stronger stuff. Things like Dihydrocodeine and even codeine are a great high, especially if you've never used opiates before.
 
As a person who suffers from a rare neurological condition known as Autonomic Dysfunction and experiences severe hypersenitivity and adverse reactions to opiates I can tell you exactly how different the reactions are to each opiate. I have been through a trial period testing different opiates to find one I can tolerate better than the other for my chronic pain and this is my conclusion....

I was getting two types of reactions depending on the opiate:

1- Sedative Response: Morphine, Fentanyl, Codene cause depressed and opressed vitals resulting in hypotension, bradycardia, supressed breathing

2- Neuroexcitory Response: Oxycodone, Hydromorphone, Tramadol cause a stimulating elevated response resulting in hypertension, tachycardia, agitation
 
There are differences.

Natural opioids: Codeine, morphine, thebaine, noscapine, etc.

Morphine and its salts: Morphine freebase, morphine sulfate, morphine hydrochloride, diacetylmorphine (morphine diacetate; heroin), nicomorphine (morphine dinicotinate), dipropanoylmorphine (morphine dipropionate), desomorphine, acetylpropionylmorphine, dibenzoylmorphine, and diacetyldihydromorphine are closer to each other in effect (most of these are morphine prodrugs)

Semi-synthetics: Hydromorphone, hydrocodone, oxycodone, oxymorphone, ethylmorphine and buprenorphine are closer in effect to each other

Synthetics have different groups that have similar effects to one another, for example fentanyl (and its analogues), meperidine/pethidine (and its analogues), methadone (and its analogues), etc.
 
i find synthetic opiods like hydro and oxy have somewhat stimulating highs while opiates like heroin/morphine/codeine and very sedating
 
LOGan1314 said:
i find synthetic opiods like hydro and oxy have somewhat stimulating highs while opiates like heroin/morphine/codeine and very sedating
Click to expand...

Hydrocodone and oxycodone are semi-synthetics, heroin is an ester salt of morphine and a morphine prodrug. It's not a semi-synethic like hydrocodone or oxycodone are, but its not a naturally occurring opiate either - it's just a morphine ester salt (real name: morphine diacetate).
 
oh okay thank you^^ I don't know much about opiates i am more of a stimulant guy:) Thanks for the correction though i love learning new things
 
They can differentiate like other posters have said. It usually has to do with what opiate they are derived from. Codeine, Morphine, and heroin I have found have a more similar high, They're a tad more sedating, lots of nodding.

The Thebaine derivatives are more speedy (oxycodone, hydrocodone etc..) but with a high enough dosage, you'll still nod out the same.

Then Methadone and Dextropropoxyphine are a bit duller in my oppinion. The high can be achieved but it feels very heavy, and not quite as euphoric.

Ultimately though, I dont think there is that huge of a difference between any of them, as long as you take equivalent dosages. You also have to take into account that some are short acting (fentanyl, hydromorphone) and some are long acting (methadone, buprenorphine etc.) If you're an I.V user, then yes, there are differences-oxycodone hardly produces a rush (imo it doesn't at all), buprenorphine has a delayed, weak rush, heroin/oxymorphone/hydromorphone produce insane rushes.
 
Ok reading all these answers makes me want to do my weekly percs!! lol. thanks for the answers, i only usually get oxycodone anyways and still have a low tolerance only takes 4 of the 5mg oxy percs to get me goood. I wonder how long iam going to keep up this weekend only oxy use lool.
 
They all have different highs and/or therapeutic effects...this is all going to have to do not only with receptor affinity, but which receptors it has a higher affinity for...high mu-affinity will give a more sedating high while kappa-affinity can give a dysphoric, dissociative high...
 
Should have read the post above first, but--

The difference in the quality of the high is really due to which receptors the particular opioid binds to. mu-opioid receptors give you euphoria and analgesia, while kappa-opioid receptors typically are more physical and less psychological effects. Morphine and codeine agonize the mu and kappa, while thebaine etc only agonize the kappas. Subs and meth are derived from thebaine, which is why they are useful for quitting, since they fool the user into thinking that they are receiving what they need, without the euphoria. This pattern is meant to prepare the user to quit, by removing the immediate mental reward of using, but unfortunately more often than not, the users mind is conditioned to provide it's own reward, which makes any alternative opioid therapy a mostly pointless method of quitting, but some succeed when other factors are involved...

Bottom line, yes, any substance will produce a different effect than any other substance. That is the nature of (neuro) -biology, and the effects that substances have on the Human body and mind.
 
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EEhouseEE said:
Ok reading all these answers makes me want to do my weekly percs!! lol. thanks for the answers, i only usually get oxycodone anyways and still have a low tolerance only takes 4 of the 5mg oxy percs to get me goood. I wonder how long iam going to keep up this weekend only oxy use lool.
Click to expand...

Yeah,percs are a good high.I can't get them anymore b/c of the media.But now I got a script for hydromorphone 10's/500 Lortabs instead of MS Contins:30mg.'s 3 x's a day, which I don't get off on at all.Don't develope a tolerance for opiates b/c it's hell!
 
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