• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

What would happen if you added a methylenedioxy group to an ephedrine molecule?

the_integerian

the_integerian

Bluelighter
Joined
Apr 15, 2010
Messages
112
Adding a methylenedioxy group to an amphetamine or methamphetamine molecule gives you MDA and MDMA respectively. Both MDA and MDMA have similar yet different effects (from what I hear. I've never tried either). The ephedrine molecule is identical to the methamphetamine molecule accept for the addition of a hydroxy group. Ephedrine feels very similar to an amphetamine as well, though much milder and less euphoric. If you added a methylenedioxy group to an ephedrine molecule, what would you end up with? Would it be a drug with an MDA or MDMA effect profile?
 
correct me if I'm wrong but I remember reading about how Sasha thought that the molecule you speak of could be the real active metabolite in MDMA. That is one of the reasons he investigated Methylone. Both MDMA and Methylone would have this as a metabolite. I don't have time to get references but I think part was in Pihkal.
 
You'd end up with a piss poor (in terms of cardiovascular consequence) stimulant with mild psychedelic effects at best... Beta hydroxylation results in selective NE releasers along with adrenergic agonism. Add increasingly poor penetration through the BBB with the extra hydroxyl group and you have a recipe for peripheral disaster.

This is a really, really easy one to make from methylone, you don't even have to use anything harsh to reduce it. I kind of doubt it's worth it, though.
 
I agree with nuke there.

Only use for B-OH-3,4-methylenedioxy(meth)amphetamine would be to do what hillbilly hick types so often do with ordinary ephedrine, I.E reduce it to MDMA, oxidize it to the ketone (methylone), or perhaps turn it into the beta-methoxy derivative which is likely to be a beta-blocker (although likely not particularly safe)

Or maybe even try turning it into an aminorex variant, if CNBr demethylates the secondary amine, hell if I know much about aminorex SAR though.
 
Limpet_Chicken said:
I agree with nuke there.

Only use for B-OH-3,4-methylenedioxy(meth)amphetamine would be to do what hillbilly hick types so often do with ordinary ephedrine, I.E reduce it to MDMA, oxidize it to the ketone (methylone), or perhaps turn it into the beta-methoxy derivative which is likely to be a beta-blocker (although likely not particularly safe)

Or maybe even try turning it into an aminorex variant, if CNBr demethylates the secondary amine, hell if I know much about aminorex SAR though.
Click to expand...

You can reduce ephedrine to MDMA? 8o
 
We should just add a methylenedioxy- group to a methylenedioxy- group. It`ll be two times the ecstasy. Oh, better yet, let`s just have a repeating polymer of methylenedioxy- groups. We can call it plastic ecstasy. What do you mean it`s chemically impossible? Screw you.
 
ct-boi said:
You can reduce ephedrine to MDMA? 8o
Click to expand...

No, but you can reduce methylone to MDMA, as well as you can reduce the reduction product of methylone (that being methylenedioxyephedrine) to MDMA.

We should just add a methylenedioxy- group to a methylenedioxy- group. It`ll be two times the ecstasy. Oh, better yet, let`s just have a repeating polymer of methylenedioxy- groups. We can call it plastic ecstasy. What do you mean it`s chemically impossible? Screw you.
Click to expand...

(3,4),(5,6),(7,8),(9,10),(11,12)-penta(methylenedioxy)-coronenylisopropylamine, anyone?
 
^lol, masturbating furiously to ChemDraw tonight, are we?
Click to expand...

20110220-nwmy9y5eaht6nwhhnnxwky6w6t.png
 
So I hear that a vendor is now selling (giant-ass polyhedral carbon-crystal)-alpha-methyl-beta-ketone-ethyl-amine.*

Nickname: nrg-pi: the "bento-flurry". :P

*catalogue picture shows diamond structure for 'ring'; product is actually just corn starch :P

ebola
 
If the buckyball would contain nitrous oxide that would kick ass :D
Have been waiting on nano-drugs for years.

Not that it could get out of course, but there are other carbon delivery structures.
NBOMe's in micelles is coming close on a more realistic note.

Shall I rename this thread 'come up with an outrageous psychedelic molecule or alternatively put it in your body' ? Since methylenedioxyephedrine doesn't seem like a good idea at all... not that it isnt creative but beta-hydroxy-phenethylamine stimulants seem to suck in general and some of them are even highly suspect of being mephedrone metabolite toxic culprits apparently.

Ephedrine was okay to try once upon a time when I didn't even know what a proper drug was meant to be like, and synephrine is somewhere between that and ephedrine.
In the end I would be surprised if it would matter that much what you stuck to the phenylring, the hydroxy in my limited view seems to be a logical origin of adrenergic effects.
 
You must log in or register to reply here.
Top