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Phenethylamines The Big & Dandy 25E-NBOMe Thread

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Greenlighter
Joined
Nov 29, 2010
Messages
8
25E-NBOMe
pk5543.png

Link to the N-Benzyl PEA Index - For compounds including all NBOMe's

25X-NBOMe, 25X-NBOH SAFETY MESSAGE

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This is a newly discovered group of chemicals, with little history of human use.
It has already become clear that these substances carry substantial risks that must be highlighted.

Some facts you should know about The 25X - NBOMe series:

25x NBOMe chemicals have killed at "normal" recreational doses.
  • We don't know how it kills.
  • People have died from doses that are smaller than ones they've taken in the past.
  • We don't know the reasons why it is so unpredictable yet.
Doses can lead to psychotic episodes and ER visits
  • If you or people around you must take these drugs, avoid combinations and advise others to avoid it as well.
  • If someone appears to be overdosing, it is important to get medical attention quickly to minimize chance of death or injury.
These chemicals are sometimes mislabeled and sold as LSD or "acid"
  • If in doubt about your drugs, learn how to test them using testing kits/reagents. Don't have blind faith in the reputation of your source.
  • A good rule of thumb is "if it's bitter it's a spitter"
  • If you take blotters sold as LSD, swallowing them may render NBOMe type compounds inactive while swallowing LSD will work just as well!

And finally information for people pushing the dosage with NBOMe's:

The NBOMe series is known to be more dangerous than other psychedelic drug families. High doses can easily result in severe reactions such as seizures and HPPD. It is possible to get away with high doses because the mental component of the trip is mild so it may not feel as intense as other psychedelics even though there are powerful visuals. In order to try and overcome this some users take several doses to get a more intense/spiritual experience. While this does work for some, for others this is where the serious side-effects emerge.

As a result of this it is recommended that if you are seeking an intense experience, something more than eye candy, you select a different psychedelic with a higher natural intensity and better safety record such as 2C-E or LSD.

It is strongly advised that users do not take more than 1.5 doses of this drug, with one dose generally agreed to be 0.9 mg (900 ug).

Insufflating doses further increases the risk.
Click to expand...

Gonna go ahead and get out in front as these things start showing up. Do tell about your experiences with this new & interesting class of high affinity 5-HT2a agonists ;)

original post follows


Anyone heard anything ? [edit: I don't need to paste a vendor's e-mail.]


but I cannot any fist hand reports
 
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these all sound pretty interesting. And these are the n-methoxybenzyl relatives of their 2c-x counterparts.
 
MUST you inform everyone that some Chinese person is mass-producing untested and potentially dangerous chemicals?

Couldn't you have simply asked about them without quoting the stupid email?

Why do kids these days like to flaunt their all-too-common sources and risk incriminating themselves?

*sigh*

8(
 
I don't think that my post disclosed anything ! I could have asked without
saying that said chems have been produced! but that would make it a abstract question, and I thought the point of this was to talk about People mass-producing untested and potentially dangerous chemicals?
 
I'd delete your post so that you and others can actually experience those chems. Why draw so much attention?
 
most of these are brand new, and only time and responsible researching can tell us.

not to mention, make a thread for one chem. I happen to know why you are asking about these specific chems and its only going to cause problems discussing it in a commercial sense.
 
just I received 25G-NBOMe , 25E-NBOMe and 25N-NBOMe , soon I will begin research but Erny wrote that dosage for 25N-NBOMe is 400-700 mcg
25T-4 not seems on interesting compound.
 
From what I've read.. This one is the least exciting of the bunch
 
I am interested in trying this, how is it comparable to 2c-e? I would imagine the dosage is in the ug.
 
Swerlz said:
From what I've read.. This one is the least exciting of the bunch
Click to expand...

Ive read the same, though maybe the stories im reading are false or just not as accurate of the substances potential.

Id love to read/hear a few more reports.
 
As would I

Frankly, I haven't heard as much about this one compared to 25I and 25C
 
Jamshyd said:
MUST you inform everyone that some Chinese person is mass-producing untested and potentially dangerous chemicals?

8(
Click to expand...
I'm afraid it's past the point it matters much. Pretty much the whole world knows China is mass producing untested and potentially dangerous chemicals. At least you can't buy this one at headshops yet.8o

Any theories why the NBOMe series seems to be reversed in potency (D more potent than E, ect.) from the PEA versions?
 
the theory is: by adding the NBOMe group, the PEA skeleton gets shoved more to the "left" than usual (as most drawings of these molecules have the 4-substituent on the left of the structure), making the larger (E, I) substituents too crowded to be effective while the smaller (C, D) are more able to bind effectively.
 
If I am not mistaken the serotonin receptor has these subunits or transmembrane domains which are basically helices of aminoacids that make up the protein, where serotonin fits in is a sort of crevice between what looks like 3 of those helices that run parallel to each other.

There is only limited room between them which is why it would matter that the NBOMe group takes up place. It leaves less room for the PEA part, therefore it can be explained that alpha-chains as well as larger substituents cause steric hindrance with one of those transmembrane domain barrels.
 
If it will be helpful , dosage for this compound is 250mcg-800mcg (intranasally)
Maximal single dose was 1 mg and different between 800 mcg was very small.
 
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greenmeanies said:
the theory is: by adding the NBOMe group, the PEA skeleton gets shoved more to the "left" than usual (as most drawings of these molecules have the 4-substituent on the left of the structure), making the larger (E, I) substituents too crowded to be effective while the smaller (C, D) are more able to bind effectively.
Click to expand...

Solipsis said:
If I am not mistaken the serotonin receptor has these subunits or transmembrane domains which are basically helices of aminoacids that make up the protein, where serotonin fits in is a sort of crevice between what looks like 3 of those helices that run parallel to each other.

There is only limited room between them which is why it would matter that the NBOMe group takes up place. It leaves less room for the PEA part, therefore it can be explained that alpha-chains as well as larger substituents cause steric hindrance with one of those transmembrane domain barrels.
Click to expand...

Nice explanations. Thanks for teaching a layman. :)
 
So the steric hindrance is going to decrease the efficiency and affinity at the receptor sites? Considering the energy to bind to the receptors under such conditions I'd imagine they wouldn't as readily bind nor stay binded for very long, contributing to a lower potency at the receptors.
 
The N-benzyl portion fits into a different part of the receptor, it might cause the phenethylamine portion to be shifted over slightly, but not a great deal. Maybe there will be slightly less tolerance for bulky 4-substituents in the N-benzyl derivatives, but I doubt ethyl would be too big.

Edit: As psykap wrote, it's not. I guess that's more potent than 25D?
 
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