• 🇳🇿 🇲🇲 🇯🇵 🇨🇳 🇦🇺 🇦🇶 🇮🇳
    Australian & Asian
    Drug Discussion

    Welcome Guest!
    Posting Rules Bluelight Rules
  • AADD Moderators: Tronica

MDMA - Thyroid Function Implicated in Hyperthermia Model

phase_dancer

phase_dancer

Bluelight Crew
Joined
Mar 12, 2001
Messages
6,178
Location
Australia
Hypothalamic-Pituitary-Thyroid Axis and Sympathetic Nervous System Involvement in Hyperthermia Induced by 3,4-Methylenedioxymethamphetamine (Ecstasy)

Jon E. Sprague, Matthew L. Banks, Valerie J. Cook and Edward M. Mills

The Department of Pharmaceutical and Biomedical Sciences, The Raabe College of Pharmacy, Ohio Northern University, Ada, Ohio (J.E.S., M.L.B., V.J.C.); and National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland (E.M.M.)

An acute and potentially life-threatening complication associated with the recreational use of the 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) is hyperthermia. In the present study, Sprague-Dawley rats treated with MDMA (40 mg/kg s.c.) responded with a significant increase (maximal at 1 h) in rectal and skeletal muscle temperatures that lasted for at least 3 h post-treatment.

Hypophysectomized (HYPO) and thyroparathyroidectomized (TX) animals treated with MDMA (40 mg/kg s.c.) did not become hyperthermic and in fact displayed a significant hypothermia. The HYPO and TX animals were also resistant to the serotonergic neurotoxic effects of MDMA assessed by serotonin measurements 4 to 7 days later in the striatum and hippocampus. MDMA (40 mg/kg s.c.) induced a significant increase in thyroxine levels 1 h post-treatment. Thyroid hormone replacement in TX animals returned the hyperthermic response seen after MDMA.

Prazosin, an 1-antagonist (0.2 mg/kg i.p.), administered 30 min before MDMA significantly attenuated the MDMA-induced increase in rectal temperature, but had no effect on skeletal muscle temperature. Cyanopindolol, a 3-antagonist (4 mg/kg s.c.), administered 30 min before MDMA (40 mg/kg s.c.) significantly attenuated the increase in skeletal muscle temperature, but had no effect on the rise in rectal temperature.

The combination of prazosin and cyanopindolol resulted in an abolishment of MDMA-induced hyperthermia. The mechanisms of thermogenesis induced by MDMA seem to result from an interaction between the hypothalamic-pituitary-thyroid axis and the sympathetic nervous system, wherein mechanisms leading to core and skeletal muscle hyperthermia after MDMA exposure seem to be differentially regulated by 1- and 3-adrenergic receptors.
Click to expand...

...MDMA (40 mg/kg s.c.) induced a significant increase in thyroxine levels 1 h post-treatment. Thyroid hormone replacement in TX animals returned the hyperthermic response seen after MDMA.
Click to expand...

This is indeed interesting. I've known a few people over the years who have had thyroid problems and have also used MDMA frequently. They definitely are among the heaviest sweeters while on the drug. I've also wondered about speed and the possible thyroid toxins (iodo-compounds, aziridines etc) produced via the pseudo methods. However, thyroid complaints are quite common, and I've usually been shot down in flames when I've suggested such things.

But as thyroid is influenced by pituitary and pituitary influenced by hypothalamus, and we've known for some time MDMA hyperthermia is induced by (5HT) actions on the hypothalamus, I've always been a bit inclined to think MDMA could affect thyroid function. If someone had a predisposition to a thyroid condition, it makes sense that they may inclined to get hotter, and therefore incur more neurological damage.

Of course if you do suffer from hyperthyroidism, you should not take any amphetamines or sympathmimetic amines anyway. The condition causes increased sensitivity and response to catcholamines, so any drug which stimulates them could also increase effects like palpitations, shortness of breath etc. Alcohol, caffeine and nictotine should be also avoided.


Thanks to Rhodium for finding the article


Here's the original article
 
Last edited:
I wanted to bump this article to see if anyone has ever had experience with thyroid related illness which may have been suspected of being related to MDMA use.

Even if you are pre-disposed to thyroid conditions (Graves Disease etc) it may be that MDMA could exacerbate an underlying condition, as all sympathomimetic amines influence the organ when in a hyperactive state.

So, anyone ever have a blood test after a binge period followed by illness, only to find levels of T3 and T4, (or TSH) were altered significantly?
 
I don’t think what I’m currently experiencing (hypothyroidism) has anything to do with the use of MDMA but I wanted to ask the question as I can’t seem to find anything on it.

I’ve been on thyroxine for 13years, I was diagnosed with an under active thyroid at 9 and had it removed at 15 as it was growing and if I had not had the operation it would of eventually killed me by blocking my airways (at least this is what I can remember of all the doctors visits, I was young and didn’t really understand it, and most of the time I sat outside the doctors room).

Anyway I ran out of medication about 6 months ago and didn’t bother going to get a new prescription as I’ve thought all along the medication doesn’t make me feel any better anyway. So the last couple of weeks I must admit I feel shit, im rundown, depressed, my hairs falling out, I’ve put on weight and been constipated. I know what I did was stupid and everything and I’m paying for it.

But I do have a question, I’ve not taken my medication for about 3 to 4 months once before but didn’t feel anything like what I do now. The time I’ve done it before I had not done any E, whereas this time around in that 6 month period of not taking my medication I have done E at least once a month. Does this have any effect on what I’m currently experiencing?
 
Did you have all of, or just part of your thyroid removed? If it is the former, I would strongly advise against not taking your medication, as several important physiological functions are affected in adults.

Your noted lethergy may be indicative of a low T4 level

Hypothyroidism is noted to produce an increased sensitivity to catecholamines (including sympathomimetic amines such as MDMA and meth)
 
my wife, in the past, has had hyperthyroidism. She had an operation to correct it.

She too sweats abnormally. Although I'm going to google for some answers does anyone have more information on the variety of problems that could happen if you have pre-disoposition to hyperthyroidism, and you take MDMA.

NB: She hasn't had any thryoid type problem for the past 10 years and hasn't taken any medication for nearly that long as well.

I don't know if this is relevant but she is also hype sensitive to MDMA. A full pill will make her completely delusional, for example stripping her clothes and wanting to run through a crowded room whilst yelling to people that god loves you etc.

For her a 1/3 is normally sufficent for a pretty good time. She probably rolls though about 1-3 a year.

Is this all linked? Anyone with hyperthyroidism sensitive to MDMA dosages?
 
phase_dancer said:
Did you have all of, or just part of your thyroid removed?
Click to expand...




I had all of my thyroid removed.
I know now not to miss taking my medication.. But the affects have never been this severe before, so i thought maybe it could have been hightened because this time i didn't take my medication i had used e?
I'm in the process of joining a support group so i can find out more info, but i don't know how i'd go with asking them weather me taking e might affect my condition? =D
 
^^ Meet the group. Once they've discovered you're a lovely person, then ask =D

Seriously though, there are undoubtedly many MDMA users out there with thyroid problems. Some of these people will possibly not identify with the symptoms and so not know there's a problem. Bringing awareness to such a group may even lead to future research being done on the topic.

So be brave and confident. You may find you know more about the subject than most of the group. You could even quote something from the above paper and ask for comment.
 
Thanks, i never really knew how serious not taking my medication was until i didn't do it.
I've been doing alot of research lately and even tho the support group i have found incurs a membership fee i'm still willing to pay that and keep up to date with all there is to know about it rather than be stupid and do something like not take my medication again...
 
You must log in or register to reply here.
Top