Zolpidem Receptor Affinity?

[arctica]

Doesn't 4-HO-DMT inhibit activity in the MRN/NCS?

Could you repost that link, please? It's 404ing.

(n = 8), p < 0.01, t-test).

I often feel this way when reviewing papers.

 

[Hammilton]

Unlikely. However, due to the recent discovery of racemic Zopiclone's potent anticholinergic effects, it would stand to reason that other drugs of the Imidazopyridine group would also be antimuscarinic drugs. Therefore, I believe it's highly likely that Zolpidem also possess anticholinergic effects.

Zolpidem has no affinity for H1 receptors, and I doubt many do, especially considering that flumazenil reverts poisoning symptoms. Were there significant effects at H1 receptors overdose would look very different.

 

[atara]

Unlikely. However, due to the recent discovery of racemic Zopiclone's potent anticholinergic effects, it would stand to reason that other drugs of the Imidazopyridine group would also be antimuscarinic drugs. Therefore, I believe it's highly likely that Zolpidem also possess anticholinergic effects.

Zopiclone isn't an imidazopyridine... it's a pyrazo[2.3-c]pyrrole. The aromatic systems are similarly-shaped, but a critical difference is the presence of a basic amine on the zopiclone sidechain which is absent from zolpidem.

Also, I haven't heard of any mAChR antagonism in zopiclone. It is a nicotinic antagonist, but this is a somewhat different story methinks. I can only imagine zolpidem seems dissociative due to direct GABA agonism, similar to muscimol/gaboxadol, which are somewhere between dissociative and deliriant.

(also, was this worth reviving the thread for?)