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Z-Drugs - Have their Hallucinogenic properties been fully established?

monstanoodle

monstanoodle

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Has it been completely established yet as to why Zolpidem (and with some people Zopiclone) gives hallucinatory effects?
I'd imagine it would be similar to how Muscimol causes hallucinatory effects, though I've never tried Fly Agaric except a taste of one when a friend bought a cap. It tasted like Soy sauce ^_^

What effects do GABAc agonists have? Could this have any connection to the visual effects of Muscimol? It's apparently also a potent partial agonist at the GABAc receptor.
Click to expand...

Would like to know if any of the ADD guys have any clues :) Cheers.
 
Reports with zolpidem are pretty common. It's completely unrelated to muscimol or gaboxadol. Hallucinations are described as being similar to 5HT2a agonists, and never with GABA-A gaba-site agonists.

Best answer is that it's caused by effecting GABA-A receptors in the visual cortex that interact with serotonergic neurons. But this has been discussed a billion times.

GABA-C receptors aren't that different than GABA-A receptors. They just have subunits not found in GABA-A receptors, but they're still Cys-loop LGIC's.
 
I never had any visual effects on z drugs (tried Zolpidem and Zopiclone).

With Zolpidem I once experienced something vaguely like PCP. But it was most certainly as far as you can get from Serotonergic Psychedelics.
 
Right, but if you read the reports, the descriptions and comparisons are always to serotonergic psychedelics.
 
Personally, I find them more deleriant then psychedelic. I've taken zolpidem and zopiclone in HUGE doses, and do enjoy the relaxing properties, but they knock out the ability to remember anything whatsoever. I don't think they share any resemblance to serotonergic psychs at all really.
 
Hammilton said:
Right, but if you read the reports, the descriptions and comparisons are always to serotonergic psychedelics.
Click to expand...

Maybe because the vast majority of people who have something to compare it to have more likely tried a serotonergic psych than PCP? ;).

I would like to point out something I actually started a thread about here a while back and got little response: the fact that zolpidem gave me a dissociative "signature" in my tongue that I associate with NMDA antagonists...
 
When I was 14 or 15 I had a script for ambien 10s and abused the shit out of them...


I've tripped alot since then on 'classical' 5HT psychedelics and I'm very surprised that you guys are even comparing the two. Sure, ambien is trippy, but at least for me, it's completely different and I always assumed there was a very different mechanism of action.

Zolpidem feels very delerient-ey, like someone else said.
 
I can sort of agree with the delerient-esque visuals of Zolpidem, but I also agree with it has a dissociative edge to it also.

It's a weird, weird drug.
 
I just want to clarify something.
When people here are using the term "hallucinogenic" in relation to Z-drugs, are they actually true auditory/visual/tactile hallucinations?
I would find that hard to believe, tho Ive never had this class of drugs at a huge dose.

The Z drugs definitely could be said to be sort of non-descriptively "trippy", but having actual hallucinations??? I doubt it.

Your perception is way off for sure, and things may appear a bit "skewed", but I would not go nearly as far as to call it hallucinogenic.
 
There's not things coming out of the walls or pink elephants or such and such, but there's movement of items and things akin to that. It's definitely not on par with Acid or Psilocin or DMT or other Tryptamines, but there's definite visual activity.
 
I have definitely experienced OEVs reminiscent of classical serotonergics on high doses of zolpidem.
 
Ambien scares the shit out of me. A) for the very notion I honestly considered dropping a hair dryer in the tub while showering after a week of being on it for insomnia(albeit while listening to the smiths) and wasn't phased by it in the slightest. B) A roomate of mine from college used to take it and 20 minutes later it was like an unmedicated shitzophrenic had arrived in my home to chat. All this came to head one evening when she had medicated, came into my room with some green and a bottle of red and an hour later was passing out sitting up only to wake up screaming about being in a bomb shelter and about the (non existent)person sitting in the corner of my room/the fat woman singing in the kitchen, amongst other craziness. Totally believe that shit can cause full blown psychotic hallucinations.
 
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