Opioids Your Tolerance Experiences: What Goes up Must Come Down? Highs Vs. Lows

[Numb19]

So being that there is very limited (if that) understanding of the mechanisms of opiate/opioid tolerance, and it seems, like effects and withdrawal etc., everyone is different.

The only consensus seems to be that only time can reduce tolerance (and for some this is even seems to be debatable).

*Note: By tolerance, it is meant the amount you would dose at one time.

So I suppose the questions are:

What was your DOC?

What was the highest your tolerance reached?

What was the lowest you were able to get your tolerance after the above?

How long did it take and did you achieve it by any other means than abstinence?

 

[Crankinit]

What was your DOC?

''Choice'' isn't strictly accurate, but oxy is the opiate I used the most before going onto suboxone, so we'll go with that.

What was the highest your tolerance reached?

240mg oral/120mg IV (I found IV to double the potency).

What was the lowest you were able to get your tolerance after the above?

It's never gone down (on account of my being on the same suboxone dose for the last 2 + years, with increasingly occasional breaks), although interestingly once I swapped to IVing, it stayed in that exact same place for 9 or 10 months until I went onto subs. In fact it's still pretty much in the same place as far as I know.

How long did it take and did you achieve it by any other means than abstinence?

NA.




I'm gonna pull the bandaid off quickly for you - mate, there's no quick and easy tolerance reversal. Yes there's talk about naltrexone and NMDA antagonists (I never found the latter to do anything, although DXM potentiates codeine amazingly), but nothing solid. Tolerance is a weird thing (as my answer to your third question shows), but with the exception of abstinence, it's generally a one way street. And even with abstinence, well, once you've paved a street, you tend to run along it a lot faster from then onwards.