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Your thoughts on the LSZ experience and it's pharmacology.

Lysergamided

Greenlighter
Joined
Nov 20, 2013
Messages
33
Location
Canada
First off, I'm new here but I've been an avid reader of a variety of drug forums to obtain information about psychedelics and other drugs but I mostly read scientific articles I find on the interwebs. I recently acquired some Lysergic acid 2,4-dimethylaztedide and sampled it with a friend and a sitter. I took a 150 micrograms blotter and put it on my tongue with one of my friends swallowing it quickly after tasting it, it tasted slightly like ink and mainly like paper. I found it very good at first with apparent euphoria and pupil dilation about 1 hour after taking it but not visual for about 1 hour more after onset. My friend felt the onset around the same time and with apparent euphoria and pupil dilation. After I started coming up I found I was hellishly anxious with loads of body energy, now given that I use stimulants often I found this very surprising. My friend didn't have anxiety but at this point he wasn't feeling much but euphoria. My anxiety went away after taking 2mg of ativan and laying down in another room, I peaked shortly after taking the ativan. I started feeling a lot of euphoria and the visuals started, there wasn't as much visuals as LSD like patterns and vivid tracers(in high doses) but there was faint tracers and other visual phenomena at 150 micrograms. At this point my friend who is double my size(I'm 140 pounds, he is about 300 pounds) was disappointed that he didn't start getting visuals so I gave him another blotter to take. As soon as the 2nd blotter started hitting him, he said he felt amazing and I noticed he started getting tracers too and in the same places I was getting them. Laughter was increased more so then some of my best LSD trips. My friend and I both noted a slight headache that was on and off during the trip mainly in the later half, we both were smoking cannabis thru out the experience. Our sitter was also smoking cannabis but he didn't experience a headache. Shortly after my friend started peaking on the 2nd hit of LSZ, both my friends left and my friend(who took the LSZ) checked up with me on facebook when he arrived at his place. He said he was at a +++ and that 300 micrograms was very tolerable, then he got offline and went to go see a lady friend(lucky bastard). I wanted to push the experience further so I took 75mcgs more(half a blotter). I waited about 2 hours for the 75mcgs to peak and then took 75 more mcgs as I felt it was very tolerable on the body. The visuals started increasing but never went to a level of lucidity like LSD but it is a good runner up. Colours appeared on things that were gray, art came alive and started shifting. I found it had a erotic component to it which was interesting because with all psychedelics I have tried previously, I have never felt it was the right time or place to do that sort of thing. Something noteworthy here is with vasoconstriction it is very hard to it get up and I found it very easy to do so on LSZ(I also asked my friend if he experienced this when he was with his lady friend and he confirmed it) this gives good anecdotal evidence that LSZ in doses of 150-300micrograms doesn't seem to produce much vasoconstriction(in fact I found the vasoconstriction to be more gentler then LSD's but the mental effects less forgiving then LSD). Mucus production and saliva production were increased like LSD. I was having some odd movements with my lips(somewhat like twitching but more repetitive) which I have gotten on LSD before. I had slight stomach discomfort but I took the blotters on an empty stomach nothing too bad. This experience lasted about 18 hours, because I increased the dose of LSZ about 4 hours into the experience and then 2 hours after that. I feel this experience was a +++ and worth exploring again. I felt exhaustion the next day but I did increase the dose several hours into the experience. This is something else that is odd because I usually have more energy the day after a trip. I believe the exhaustion is explained via a lack of good sleep quality as I have never tripped for that long before or that late into the day. LSZ is a good alternative to LSD but can difficult at times, It's worth it for the experienced or brave tripper or someone with a strong mental state. If I had to pick between LSD and LSZ I would pick LSD over LSZ but if I couldn't find LSD or if I lived in a country where LSZ is legal to import , I would do so. I would like to finish this trip report with saying that if my LSZ vendor get AL-LAD in stock again that I will be obtaining some of it to sample as well. I hear AL-LAD is a very good, gentle compound and Shulgin's reports on it are intriguing.

Now I have somethings to say regarding my experience and LSZ's most active isomer's pharmacology. LSZ's (S,S)+ isomer binds better to 3 dopamine receptors then LSD, which are D3, D4 and D2, respectively. This is why I believe I had such high body energy and anxiety during the come up of the experience. This isomer also binds better to the 5HT1A, 5HT1Da and 5HT2B respectively. It's affinity for 5HT2C is comparable to LSD but it does bind less to 5HT2A which is why, I believe the visuals never got very vivid in the trip. I would like to note that 2C-B doesn't bind very well to 5HT2A and is fully hallucinogenic. Another thing to note about this isomer of LSZ is that it showed the highest LSD-like behavior in drug discrimination rats out of all the LSZ isomers. I think it fully substituted for LSD in drug discrimination rats(don't quote me on this). It is slightly more potent then LSD itself.

Reference for LSZ's isomers pharmacology vs LSD's: http://www.erowid.org/archive/rhodium/pdf/azetidine-lsd.pdf


What is your opinion on LSZ's effects/side-effects? What is your opinion on it's pharmacology? Do you like LSZ? Was it enjoyable? Is it worth repeating? ?Was it harsh/difficult? Did it make you fathom hell or soar angelic?

10 blotters of LSZ I purchased(I have checked the controlled substance act in my country, this compound is 100% legal here)
ipwRuTI.jpg


Backside of the blotters
zlmHmAt.jpg


P.S. I believe all the LSZ and AL-LAD on the market as of Nov 2013 is being produced by one lab as it is on blotter that is very similar to each other and require similar precursors (al-lad is made from nor-LSD and I believe that is made from lysergic acid or possibly LSD). LSZ is made from Lysergic acid. If you live in a country where lysergic acid derivatives are controlled then this substance is controlled in your country. In my country Lysergic acid is controlled but not it's derivatives, only LSD(and it's salts), Ergomentrine(and it's salts, found in Ipomoea tricolor, Ergot and Hawaiian baby woodrose seeds. it has LSD-like action at doses of 2-10mg according to Shulgin), Ergotamine(and it's salts, found in ergot) and lysergic acid itself(and it's salts, I believe it's made from ergopeptides like ergotamine via hydrolysis) are controlled. LSD is a schedule III(3) drug in the CDSA(Controlled drug and substance act) of Canada, which is the 2nd harshest Schedule. The precursors stated here are Schedule VI(6) substances, Schedule VI only features precursors of controlled substances like ephedrine, pseudoephedrine, safrole, isosafrole, etc.

Thank you for reading. ;)
 
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Nice introduction. I didn't get to digest it all just yet (time constraints) but without going much into detail I'd just like to say, the synthesis for these lysgeramides didn't require LSD as a precursor. I'll get back with you later with some other thoughts.

Welcome to Bluelight!
 
Nice introduction. I didn't get to digest it all just yet (time constraints) but without going much into detail I'd just like to say, the synthesis for these lysgeramides didn't require LSD as a precursor. I'll get back with you later with some other thoughts.

Welcome to Bluelight!

Thank you for the welcome. What I meant was that AL-LAD is made from nor-LSD but I don't know what nor-LSD is made from It's probably made from lysergic acid like most psychoactive lysergamides.
 
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Firstly: welcome to Bluelight and PD

First-and-a-halfly: that is probably quite enough with the synthesis discussion. Please read our rules.

Secondly: interesting quick TR or effects summary and I guess decent SAR speculation, but don't confuse affinity with efficacy, yada yada. You still have a good point though.

Would you agree this belongs in the Neuro & Pharmacology forum (former ADD)? The audience you pick may very well determine what is focused on and perhaps someone will share some great theoretical material with us...
 
First-and-a-halfly: that is probably quite enough with the synthesis discussion. Please read our rules.


Aye aye captain!

I'll post some theories regarding binding later when I have more time. Basically I visit this forum between breaks, consequently too often but not too long. :p

Certainly by weight LSZ I believe has a lower efficacy than LSD. I'm not so sure LSD even really has a higher threshold then LSZ as previously thought. It seems debatable, IMO. Also seems like there's certainly a lower affinity for 5-HT1B that could allow the 5-HT2A to cause higher amounts of vasoconstriction, particularly in the legs.
 
So what are the thoughts of the assorted folks on the forum on the question of 5-HT1D agonism? That particular part doesn't sit very well with me.

I could be imagining it, but during my 450ug LSZ trip, I had the most weird and unwelcome headache, and a feeling of unpleasant warmth in the cranial area. I don't think it was placebo, since I didn't learn about the 5-HT1D issue until the next day, when I did some research, prompted by the rather bad time I had the previous night.
 
So what are the thoughts of the assorted folks on the forum on the question of 5-HT1D agonism? That particular part doesn't sit very well with me.

I could be imagining it, but during my 450ug LSZ trip, I had the most weird and unwelcome headache, and a feeling of unpleasant warmth in the cranial area. I don't think it was placebo, since I didn't learn about the 5-HT1D issue until the next day, when I did some research, prompted by the rather bad time I had the previous night.
On 300 micrograms both my friend and I reported a headache that was on and off during the later half of the experience.

Doesn't activation of 5HT1A cause peripheral vasodilation?
 
Yes likely leads to decreased heart rate, hot face, etc. At the same time it probably leads to decreased visual activity in LSZ vs. LSD.

Personally I did not notice any headaches but a high amount of vasoconstriction at all doses, 75mcg, 150mcg, 300mcg and 450mcg.
 
Yes likely leads to decreased heart rate, hot face, etc. At the same time it probably leads to decreased visual activity in LSZ vs. LSD.

Personally I did not notice any headaches but a high amount of vasoconstriction at all doses, 75mcg, 150mcg, 300mcg and 450mcg.

Odd that you got a lot of noticeable vasoconstriction. I think because of LSZ's reduced affinity for some receptors and increased for others it probably has vasoconstriction comparable to LSD. It does have quite high affinity for the 5HT1A receptor and activation of this receptor would cause peripheral vasodilation. I found the vasoconstriction of LSZ to not even be bothersome, I did notice that my hands were slight red but I believe that was colours shifting and the lighting in the room I was in. I have done 2mg of 25i-nbome HCL before and that stuff was so vasoconstrictiing that when I need to go for a number 1, I stood over the toilet seat, squeezing my bladder to relieve myself, this went on for a good 20 minutes at least. The squeezing was actually painful to do.
 
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Squeezing is a bit counterproductive when you have this urgency effect because you try to push it despite the constricted muscles that keep you from being incontinent. Really focusing on those muscles to try and access and override control over them (meditate if you have to) seems to work a whole lot better. But yeah I know when on some drugs it's just no use and you probably knew already what I just explained.
 
450 produced some scary as shit vascodialation but it passed in 10 minutes. With mdpv I always found ground cayanne pepper in a capsule to help.

I'm too drunk and lazy to post a link but check out the LSZ trip report I posted a few months back. Those 10 minutes of fear led to the most significant LSx experience of my life. Crazier than 7 clear gel tabs, or unknown amoumts of liquid or 6-7 solid blotters. Still sketchy with an unknown compound but god damm did I get spanked.
 
450 produced some scary as shit vascodialation but it passed in 10 minutes. With mdpv I always found ground cayanne pepper in a capsule to help.

I'm too drunk and lazy to post a link but check out the LSZ trip report I posted a few months back. Those 10 minutes of fear led to the most significant LSx experience of my life. Crazier than 7 clear gel tabs, or unknown amoumts of liquid or 6-7 solid blotters. Still sketchy with an unknown compound but god damm did I get spanked.
What was the vasoconstriction comprised of? What were your physical symptoms like that you experienced?
 
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