Misc Xylazine withdrawal sucks!

[tibberous]

I didn't think there existed anything worse than opiate withdrawal. Especially because I don't even like Xylazine.

But unlike opiate withdrawal that doesn't start until about 12 hours, Xylazine had me puking within probably 10. For 2 solid days I puked, even while taking copious amounts of odansetron. An anti nausea medicine used for chemotherapy wasn't strong enough to keep me from straight puking.

About the only thing I can say good about Xylazine withdrawal is that you can take fentanyl for it, and that helps (thankfully I could still get fentanyl without Xylazine). But by day 2 I was out of money and out of fentanyl and just had to power through. Thankfully I didn't have the bright idea to take more Xylazine - that shit is actual poison, and this is coming from a guy who's been narcan'd 6 times and had a stroke from taking fentanyl.

All I can say is, never again. I don't even shoot up, but I can feel 2 lesions on my sinuses from that crap. It just sucks, because the best, cheapest fentanyl I can get now has Xylazine in it. But nothing is worth that. My chest literally hurts from puking, I've had maybe 1000 calories in 3 days, mostly as popsicles i puked up. I didn't sleep for 2 days, and when I finally did, I had horrible nightmares. The only good thing I can say is that today I felt good enough to find money, find fentanyl, and now I'm actually keeping down food. So, if you think you are actually going to die from Xylazine withdrawal, you probably won't - it actually doesn't last as long as opiate withdrawal. The other benefit is that, since I don't even like Xylazine, there was no "craving" to do more. If anything, there was the opposite - a desire to never touch that crap again!

Someone with some chemistry skill should figure out a way to separate it out of fentanyl. It seems like it would be pretty simple - just find a solvent that fentanyl dissolves in and Xylazine doesn't, or vice versa. If I had some extra cash I'd be tempted to buy a brick and just try to run through common solvents. Acetone, toluene, ethanol, water, ECT. There has to be a way to separate this crap out. Yeah, it'd be a pita, since you'd have to dump out 50 bags, and maybe even recut the fetty, but if you are on a budget - even getting out 80-90% would be better than nothing. I just don't get who thinks adding this crap makes fentanyl "better". 1) fentanyl is already awesome and 2) Xylazine is a totally different high. The fact that no one is dealing straight Xylazine seems like proof that no one would do this crap if it wasn't mixed with fentanyl. And that's not saying much, I'd probably snort battery acid if it was mixed with enough fentanyl but even adding fentanyl isn't enough to make me do more Xylazine.

I'm just glad Ohio's supply isn't polluted with this crap. There has to be a market for non-tranq fetty. It's just nuts because I remember when the news was saying that fentanyl was just "adulterated heroin", but I was actively trying to buy straight fetty (especially because I was on probation and fetty wasn't on the dipstick test). But now they really have just screwed up the drug supply. I've never felt bad about selling drugs, but I don't even want to deal this crap. Sad part is, if I had been doing the "high tolerance" bags I liked, i probably wouldn't have withdrew half as bad. I got these stupid "Maybachs", and you had to do like twice as many to really feel the fetty. It's a wonder I'm not dead or jail for falling asleep while driving. Ah, prohibition - it's working great. Good thing those deadly oxycodones are impossible in find. But I got 6 people I can buy fentanyl from, and half of it has horse tranquilizer. The government needs to let me kill myself in peace, because at least I won't do it by driving a 2000 pound SUV into innocent people.

 

[SeekingOblivion]

The Overton window.

 

[tibberous]

Surprisingly, i got Gemini to skirt its "drugs are bad" message and provide some possibly useful information. The obvious problem is that if doesn't have a solvent that fentanyl isn't completely soluble in. And since it's expensive, I'm not sure how practical it would be to lose any fentanyl just to separate out the tranq. Anyway, per Gemini:

You're right, there's not a lot of readily available information on separating xylazine from fentanyl specifically in an illicit context, as this isn't a process that's typically studied or published by legitimate scientific bodies. The information available tends to be about identifying xylazine as an adulterant, or its effects.
However, if we approach this purely from a hypothetical chemistry standpoint, the most common methods for separating compounds in a mixture rely on differences in their physical and chemical properties, primarily solubility and acid-base characteristics (pKa).
Here's a breakdown of how one might hypothetically attempt to separate xylazine from fentanyl, based on their known properties:
Key Properties to Consider:
* Xylazine:
* Solubility: Soluble in methanol (50 mg/mL), dilute HCl, chloroform, ethanol (20 mg/mL), DMSO (30 mg/mL). Practically insoluble in water and alkali solutions.
* pKa: ~7.67 (predicted). This indicates it's a weak base.
* Form: Crystalline solid (when dried from solution).
* Fentanyl (often as Fentanyl Citrate):
* Solubility: Fentanyl citrate is sparingly soluble to soluble in water, sparingly soluble in alcohol, slightly soluble in chloroform, soluble to freely soluble in methyl alcohol (methanol). Pure fentanyl (free base) would be less soluble in water and more soluble in organic solvents.
* pKa: Fentanyl (the free base) has a pKa of about 8.4. This also indicates it's a weak base.
Hypothetical Separation Methods (Purely for Discussion):
* Differential Solubility / Solvent Extraction (Likely the most practical theoretical approach):
This method exploits the idea you mentioned: finding a solvent where one dissolves and the other doesn't, or where their solubilities are significantly different.
* Scenario 1: Xylazine is soluble, Fentanyl is not (or less soluble).
* Acetone Wash (as you speculated): Xylazine is generally soluble in common organic solvents like acetone. Fentanyl (especially as the citrate salt) has varying solubility in acetone. Some sources suggest fentanyl citrate is "sparingly soluble in acetone." This is a promising avenue. If fentanyl is less soluble in cold acetone than xylazine, an "acetone wash" could hypothetically remove some xylazine while leaving more fentanyl behind. The process would involve dissolving the mixture in a minimal amount of cold acetone, filtering out the undissolved fentanyl (or precipitate if it crashes out), and then evaporating the acetone from the filtrate to recover the xylazine.
* Chloroform: Xylazine is soluble in chloroform, and fentanyl citrate is slightly soluble. This might work, but "slightly soluble" could still mean a significant amount of fentanyl dissolves.
* Methanol/Ethanol: Both are soluble in methanol and ethanol to some extent. This would make simple separation by differential solubility difficult, as both compounds would dissolve.
* Scenario 2: Fentanyl is soluble, Xylazine is not (or less soluble).
* This is less likely with common organic solvents, as xylazine seems to have broad solubility in many of them.
* Acid-Base Extraction (More complex, but often more effective for separating bases):
Both fentanyl and xylazine are weak bases, meaning they can be protonated (become positively charged) in acidic solutions and deprotonated (become neutral) in basic solutions. Their pKa values are relatively close (xylazine ~7.7, fentanyl ~8.4), which makes this more challenging but not impossible.
* The principle: A basic compound is more soluble in water when it's protonated (acidic pH) and more soluble in organic solvents when it's neutral (basic pH).
* Hypothetical Steps:
* Dissolve in organic solvent: Dissolve the fentanyl/xylazine mixture in an organic solvent (e.g., dichloromethane, chloroform, or even a mixed solvent like toluene/ether).
* Extract with acidic water: Add an acidic aqueous solution (e.g., dilute HCl, pH 2-3). Both fentanyl and xylazine, being bases, would become protonated and move into the acidic water layer.
* Adjust pH differentially: This is the tricky part. Slowly raise the pH of the aqueous layer.
* As the pH approaches 7.7 (xylazine's pKa), xylazine will start to deprotonate and become less soluble in water.
* As the pH approaches 8.4 (fentanyl's pKa), fentanyl will start to deprotonate and become less soluble in water.
* By carefully controlling the pH (e.g., raising it to about 8.0), one might be able to get most of the xylazine to deprotonate and become extractable back into an organic solvent, while a significant portion of the fentanyl might still remain protonated in the water.
* Sequential extraction: At the target pH, extract the aqueous layer with a fresh organic solvent. The deprotonated compound (the one whose pKa has been "passed") will move into the organic layer.
* Separate and purify: The organic layer containing the separated compound can then be evaporated, and the remaining aqueous layer can have its pH adjusted further to extract the other compound.
* Challenges: The close pKa values mean that complete separation with a simple acid-base extraction would be difficult, and you'd likely get overlapping fractions. It would require precise pH control and potentially multiple extraction steps.
* Recrystallization:
This involves dissolving the mixture in a hot solvent and then slowly cooling it, causing the less soluble compound to crystallize out first.
* Hypothetical: If there's a solvent where the solubility of one compound changes drastically with temperature, and the other's doesn't, or if one forms crystals more readily, this could be attempted. However, identifying such a solvent without detailed solubility data for both compounds across temperature ranges would be trial and error.
Important Considerations for ANY Hypothetical Separation:
* Purity of Starting Materials: Illicit drugs are rarely pure. They contain other cutting agents, impurities from synthesis, and potentially other active compounds. These would complicate any separation attempt.
* Safety: Handling these chemicals, especially fentanyl and xylazine, is extremely dangerous due to their potency and toxicity. Even small amounts can be fatal. Working with solvents (acetone, methanol, chloroform) requires proper ventilation, fire safety, and personal protective equipment. This is a crucial point, as any experimentation in an uncontrolled environment could have severe consequences.
* Yield and Efficiency: Even if a method could theoretically separate them, the practical yield of pure compounds might be very low, making the process inefficient.
* Form of Fentanyl: Fentanyl is often sold as fentanyl citrate, a salt. This is more water-soluble than the fentanyl free base. To perform solvent extractions based on free base properties, one might first need to convert the citrate salt to the free base (e.g., by adding a strong base like sodium carbonate to an aqueous solution and then extracting with an organic solvent).
Conclusion:
While a purely hypothetical chemical separation based on solubility differences (like an acetone wash) or carefully controlled acid-base extraction might be conceived, executing such a separation effectively and safely would be extremely challenging for someone without significant chemistry expertise, laboratory equipment, and rigorous safety protocols. The risks associated with handling these substances far outweigh any potential benefit of attempting such a separation outside of a professional, controlled laboratory setting.

 

[tibberous]

The Overton window.

Yup.

Say what you will about fentanyl, but its at least FDA approved. It certainly isn't better now that it's filled with veterinary anesthesic that dissolves tissue. I'm surprised this is even safe for horses - it melts skins for God sakes.

 

[specialrelativity]

What about a morphine drip?

 

[General alcazar]

Just don’t ever take any yohimbine if the withdrawals are that bad. It’s Xylazine’s reversal agent. I also wonder why yohimbine isn’t available with naloxone given the prevalence of this garbage for people that OD. It is interesting that it causes a dependency (not for OP, obviously). I didn’t know an alpha 2 agonist could do that. The again, no one’s ever abused them until now. Xylazine is meant to be used for the occasional heavy sedation in animals, and has largely been replaced by detomidine in large animals, and medetomidine in small animals. xylazine is pretty obsolete these days, except to poison narcotic addicts…

 

[Them Witches]

Xylazine, a clonidine analog, both are Alpha-2 drugs but Clonidine is 40 times stronger. Medical evidence points to the use of Alpha-2 adrenergic agonists like Clonidine a promising intervention for managing Xylazine withdrawal symptoms. Here are the benefits to this :

> Clonidine is 40 times stronger than Xylazine & is also a Anti-Hypertensive.
> Clonidine's long half-life makes it suitable option to transition from the short acting Xylazine
> It does not cause skin sores, internal sores, and infections. The use of Clonidine will allow these health issues to be treated
> Clonidine is not that hard to get an Rx for. Off-label, from psychiatrists to family doctors can Rx it for treatment of stress, anxiety, sleep, management of withdrawals for about every drug, ADHD, PTSD, and Tourette Syndrome. It's designed purpose is treating blood pressure & pulse.
> Clonidine does cause withdrawal symptoms itself lasting 2-3 days. It normally only happens from chronic high dosages.
> Clonidine is given to potentiate the effects of opioids and it is used in pain management for cancer & non-cancer pain. It causes synergistic sedation. When used with opioids like Morphine, Hydromorphone, and Oxycodone it increases potency 10-fold. This is primarily the reason Xylazine was chosen as a cutting agent for street Fentanyl.

Something to keep in mind is Clonidine is dangerous if overdosed. It's bradycardia effects in high doses can assist in an overdose if combined with IV Opioids. This effect window can last up to 24hrs for Clonidine naive people. Do not throw caution to the wind and I hope the OP finds their way out and on to greener pastures.

 

[Gaz_hmmmm]

I've not much to add other than I hope they stop adding this awful shit.

It's started here too in England and is actually what caused me to stop using daily, cause xylazine causes me major headaches and awful sickness about 45min's after using.
Only trying to sleep helped the headaches as NSAID's like ibuprofen didn't and not much took the nausea away.

It's awful stuff that doesn't add to the high at all.

 

[Them Witches]

The irony over heroin being considered being at the bottom of the barrel and down & out compared to today's illicit fentanyl cut with xylazine. Now heroin is being begged to come back and replace fentanyl. Heroin is absolutely safer, has impressive euphoria, and has longer legs. Someone with Heroin #4 or #3 stands to make a lot of money these days and their service would be a lifesaver literally.

 

[Coffeeshroom]

I have never had fentanyl or xylazine as our H is not cut with that.

Our purity is a bit low 60-70% but at least no funny stuff.

But with that said interesting read on the yohimbine as that is always on my pets medical bills. And in the past I use to use it for localized fatburning properties.

Any properties of it that can be used just for normal opiod wd?

 

[4DQSAR]

I suspect xylazine hydrochloride is used to cut fentanyl.

Shulgin seperated NMT and AMT by reacting with acetyl chloride. Then NMT forms an amide and won't go through a B/A extraction. I suppose the same is true here. But it's quite a lot of work.

How water-soluble is fentanyl hydrochlride? I suspect sreet fentanyl isn't the citrate.

So if you redo the solubility data so that xylazine hydrochloride and fentanyl hydrochloride solubility is the starting point.

Interessting that it seems like adding xylazine was done for more than one reason. It took us ages to work out why that deworming powder was being added to cocaine and I'm still not convinced we really know. I suppose in this case we may never know for sure.

 

[Them Witches]

I have never had fentanyl or xylazine as our H is not cut with that.

Our purity is a bit low 60-70% but at least no funny stuff.

I now know where and why I need to apply for a 90-day visa in South Africa. In fact, I know a guy from South Africa that works at our local smoke shop.

Heroin has gone on a permanent vacation from the US. The junk-ass Fentanyl is everywhere now which IMO has not one redeeming quality worth mentioning.

 

[4DQSAR]

I now know where and why I need to apply for a 90-day visa in South Africa. In fact, I know a guy from South Africa that works at our local smoke shop.

Heroin has gone on a permanent vacation from the US. The junk-ass Fentanyl is everywhere now which IMO has not one redeeming quality worth mentioning.

I suggest that as of a few days ago, anyone returning to the US from South Africa might be searched a bit more often than someone who had visited Finland, to name a nation at random.

Interesting place and the only nation on earth where Mandrax is the number 1 drug problem. But there are a lot of ALL drugs - so I personally wouldn't risk importing ANYTHING.

 

[Coffeeshroom]

I suggest that as of a few days ago, anyone returning to the US from South Africa might be searched a bit more often than someone who had visited Finland, to name a nation at random.

Interesting place and the only nation on earth where Mandrax is the number 1 drug problem. But there are a lot of ALL drugs - so I personally wouldn't risk importing ANYTHING.

That aside I think there is a big misconception...
I mean we all know that the mandrax we are getting on the street even though the real deal, it's still pressed and synthesized. The real original mandrax pill was discontinued at least a decade or mor3 so. I rwmber the originals. They nothing compared to what you get today and even though the stuff you do get is 80-90% to the real deal it's still off the wall. Just the ROA that is used in S.A. that has made it notorious and famous and more so used by criminal element of S.A.

I'm already talking to much about said subject.

But be carefull what you wish for.

Edit: last post not aimed at you but anyone that comes here for just rhat exp. I would not advise it

 

[Them Witches]

the only nation on earth where Mandrax is the number 1 drug problem.

South Africa keeps looking better by the day. Sounds like a great place to travel with money to spend

 

[Coffeeshroom]

Lol...

Bakakakakakaka...

It will " sluk en spoeg " you out faster then anything if you don't know what's, what's. Back backing and going to theses spots are 2 different things and would never advise it..

 

[Them Witches]

^ Your honesty is priceless

 

[Them Witches]

Use Clonidine to deal with the Xylazine withdrawals. Xylazine is made from Clonidine and Clonidine is 40 times stronger than it.

Clonidine can be Rx'd for all kinds of reasons on-label and off-label. It too has withdrawals because it is also a Alpha2 drug.

The difference is no one knows how much Xylazine is being used to cut Fentanyl with. The good news is Clonidine is strong enough to combat that.

Start dosing Clonidine slow until the Xylazine withdrawals subside. Now you have your effective dosage. The is the most important things to determine first.

DO NOT -- Take a bunch of Clonidine because it is helping relieve withdrawals from opioids/tranq, then while Clonidine (long half-life) is still present use opioids/tranq. This is a sure way to die. Something as strong as Clonidine requires finding the correct dosage with doing illicit drugs, let alone doing them together.

*** IMPORTANT IMPORTANT IMPORTANT IMPORTANT ***

Clonidine is very strong and has a long half-life. It is extremely life-threatening to IV Opioids/Alpha2 drugs with a certain level of Clonidine still in the system. I am talking as long as 16hrs the last Clonidine does. Just like Xanax, Clonidine is risky being IV'd with opioids.

 

[thurston]

I didn't think there existed anything worse than opiate withdrawal. Especially because I don't even like Xylazine.

But unlike opiate withdrawal that doesn't start until about 12 hours, Xylazine had me puking within probably 10. For 2 solid days I puked, even while taking copious amounts of odansetron. An anti nausea medicine used for chemotherapy wasn't strong enough to keep me from straight puking.

About the only thing I can say good about Xylazine withdrawal is that you can take fentanyl for it, and that helps (thankfully I could still get fentanyl without Xylazine). But by day 2 I was out of money and out of fentanyl and just had to power through. Thankfully I didn't have the bright idea to take more Xylazine - that shit is actual poison, and this is coming from a guy who's been narcan'd 6 times and had a stroke from taking fentanyl.

All I can say is, never again. I don't even shoot up, but I can feel 2 lesions on my sinuses from that crap. It just sucks, because the best, cheapest fentanyl I can get now has Xylazine in it. But nothing is worth that. My chest literally hurts from puking, I've had maybe 1000 calories in 3 days, mostly as popsicles i puked up. I didn't sleep for 2 days, and when I finally did, I had horrible nightmares. The only good thing I can say is that today I felt good enough to find money, find fentanyl, and now I'm actually keeping down food. So, if you think you are actually going to die from Xylazine withdrawal, you probably won't - it actually doesn't last as long as opiate withdrawal. The other benefit is that, since I don't even like Xylazine, there was no "craving" to do more. If anything, there was the opposite - a desire to never touch that crap again!

Someone with some chemistry skill should figure out a way to separate it out of fentanyl. It seems like it would be pretty simple - just find a solvent that fentanyl dissolves in and Xylazine doesn't, or vice versa. If I had some extra cash I'd be tempted to buy a brick and just try to run through common solvents. Acetone, toluene, ethanol, water, ECT. There has to be a way to separate this crap out. Yeah, it'd be a pita, since you'd have to dump out 50 bags, and maybe even recut the fetty, but if you are on a budget - even getting out 80-90% would be better than nothing. I just don't get who thinks adding this crap makes fentanyl "better". 1) fentanyl is already awesome and 2) Xylazine is a totally different high. The fact that no one is dealing straight Xylazine seems like proof that no one would do this crap if it wasn't mixed with fentanyl. And that's not saying much, I'd probably snort battery acid if it was mixed with enough fentanyl but even adding fentanyl isn't enough to make me do more Xylazine.

I'm just glad Ohio's supply isn't polluted with this crap. There has to be a market for non-tranq fetty. It's just nuts because I remember when the news was saying that fentanyl was just "adulterated heroin", but I was actively trying to buy straight fetty (especially because I was on probation and fetty wasn't on the dipstick test). But now they really have just screwed up the drug supply. I've never felt bad about selling drugs, but I don't even want to deal this crap. Sad part is, if I had been doing the "high tolerance" bags I liked, i probably wouldn't have withdrew half as bad. I got these stupid "Maybachs", and you had to do like twice as many to really feel the fetty. It's a wonder I'm not dead or jail for falling asleep while driving. Ah, prohibition - it's working great. Good thing those deadly oxycodones are impossible in find. But I got 6 people I can buy fentanyl from, and half of it has horse tranquilizer. The government needs to let me kill myself in peace, because at least I won't do it by driving a 2000 pound SUV into innocent people.

I saw a warning in my neighboring state last month to beware of tranq starting to show up from Ohio.

 

[Gaz_hmmmm]

I have never had fentanyl or xylazine as our H is not cut with that.

Our purity is a bit low 60-70% but at least no funny stuff.

Where does the H in South Africa come from?

60% - 70% is good, it's better than the crap in my area of England.

I always wondered why opium wasn't grown on mass in Africa and then used to make H?

Not only is there a huge need for opioids in the Third World but there's plenty of space to get away with growing it for trafficking.

I know that Egypt did or does have a local opium/H issue and that the Portuguese historically (19th Century) grew opium in central Africa but were chased out of that place cause of the locals rebelling and I think the British aided them.